Wei Zhen Yeh

Pancake‐Like Enhancement in Spondylotic Compressive Myelopathy

Wei Zhen Yeh, Shisheng Lu

au (code pays fourni par la source)

Circulatory immune cell counts and clinical outcomes in multiple sclerosis relapse versus remission

Meltem Savran Karadeniz, Robb Wesselingh, Padmakrishnan C. Jayakrishnan, Richard P. Sequeira et autres

Multiple sclerosis (MS) relapse diagnosis is impeded by 'pseudo-relapses' whilst relapse treatment lacks specificity. Before we can improve clinical care, we must first improve our understanding of relapse pathogenesis. Currently, the circulatory immune mechanisms underpinning relapse are poorly understood. We aimed to …

au (code pays fourni par la source)

Neurosymptomatic HIV CSF viral escape with parkinsonism and amyotrophic lateral sclerosis-like syndrome: a case report

Francesca Bridge, Wesley Thevathasan, David Schultz, Wenwen Zhang et autres

Human immunodeficiency virus (HIV) infection can lead to various neurologic complications affecting central and peripheral nervous systems. Rarely, patients on combined anti-retroviral therapy (CART) with peripheral virologic suppression may develop compartmentalised central nervous system infection with cerebrospinal fluid (CSF) viral escape. We …

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Myelin oligodendrocyte glycoprotein antibody-associated disease and relapse risk: Effects of smoking and vascular risk factors

Wei Zhen Yeh, Fiona Chan, Anna G. Francis, Helmut Butzkueven et autres

Background: The effects of smoking and vascular risk factors (VRF) on relapse activity in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) are not well understood. We aimed to investigate these. Methods: MOGAD patients in the Oxford National Neuromyelitis Optica (NMO) Service with known …

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Prediction of relapse in myelin oligodendrocyte glycoprotein antibody-associated disease: external validation of the MOG-AR score

Wei Zhen Yeh, Anna G. Francis, Helmut Butzkueven, Ruth Geraldes et autres

BACKGROUND: Predicting relapses in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) when disability is relapse-dependent is crucial to guide treatment decisions including whether to treat from onset. MOG-AR, a relapse risk score, was recently developed in a Chinese cohort from disease onset. This …

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Optimal strategies for treatment discontinuation in MOG antibody-associated disease

Wei Zhen Yeh, Anna G. Francis, Sarah Cooper, Waqar Rashid et autres

The relapse risk following discontinuation of immunomodulatory treatment in myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is unknown. Evidence suggests that 'at least' 3 months of oral corticosteroids reduces relapse risk after a single attack, and that it may be possible to stop …

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The impact of CGRP monoclonal antibodies on cytokine expression in chronic migraine: a cohort study

Jason Charles Ray, Stuart J. McDonald, Marian Todaro, Josephine Baker et autres

BACKGROUND: Calcitonin gene-related peptide monoclonal antibodies (CGRP mAbs) are an effective preventative therapy for migraine; however, there have been rare reports of possible inflammatory complications. The primary objective of this study was to examine the impact of CGRP mAbs on immune system …

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Pregnancy-Related Disease Outcomes in Women With Moderate to Severe Multiple Sclerosis Disability

Jessica Shipley, Heidi N. Beadnall, Paul Gerard Sanfilippo, Wei Zhen Yeh et autres

Importance: Understanding the association between pregnancy and clinical outcomes in women with moderate to severe multiple sclerosis (MS) disability is crucial for guiding family planning and management strategies. Objective: To assess peripregnancy relapse activity and disability progression in women with a preconception …

au, cz, ca, nl, kw, tr, it, Tunisie, ir, nz, pt, es (code pays fourni par la source)

C4 genetic structural variations affect multiple sclerosis risk and progression

Xin Lin, Dongdong Tang, Yuanhao Yang, Maria Pia Campagna et autres

ABSTRACT Objective Major histocompatibility complex (MHC) locus carries a significant genetic risk burden for multiple sclerosis (MS). Here we investigate the structurally diverse complement component 4 ( C4 ) alleles within the MHC in MS development and disease progression. Methods We imputed …

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Progression independent of relapse activity and relapse-associated worsening in seronegative NMOSD: an international cohort study

Pakeeran Siriratnam, Saif Huda, Anneke van der Walt, Paul Gerard Sanfilippo et autres

BACKGROUND: Previous studies have indicated that progression independent of relapse activity (PIRA) is uncommon in patients with aquaporin- 4 antibody-positive (AQP4-IgG) neuromyelitis optica spectrum disorder (NMOSD). However, the patterns of disability accumulation in seronegative NMOSD are unknown. This study aimed to evaluate …

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Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 1

Jessica Shipley, James Beharry, Wei Zhen Yeh, Nabil Seery et autres

INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory demyelinating and degenerative disease of the central nervous system. There were 33 335 people with MS in Australia in 2021 and 2917 in New Zealand in 2006 and the prevalence and incidence are increasing …

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Consensus recommendations on multiple sclerosis management in Australia and New Zealand: part 2

Jessica Shipley, James Beharry, Wei Zhen Yeh, Nabil Seery et autres

INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system with rapidly evolving treatment options and strategies. An iterative modified Delphi process was used to develop 80 consensus recommendations for the management of MS in Australia …

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