Sébastien This

TIGAR coordinates polyol and glutamine metabolism to regulate CD4+ T cells

Julianna Blagih, Elpida Bokou Gianneli, Sébastien This, Fabio Zani et autres

ca, gb, jp (code pays fourni par la source)

Intracellular calcium dynamics are predictive of T cell receptor affinity for cognate antigen

Sébastien This, Clément Playout, Solenne Lacroix, Stefanie Valbon et autres

The strength of antigen recognition by the T cell receptor (TCR) dictates T cell fate and function. However, existing biochemical, biophysical, and cell-based approaches to quantify TCR avidity for cognate antigen are limited in their ability to scale to single-cell analysis across …

ca (code pays fourni par la source)

Intracellular calcium dynamics are predictive of T cell receptor affinity for cognate antigen

Sébastien This, Clément Playout, Solenne Lacroix, Stefanie Valbon et autres

The strength of antigen recognition by the T cell receptor (TCR) dictates T cell fate and function. However, existing biochemical, biophysical, and cell-based approaches to quantify TCR avidity for cognate antigen are limited in their ability to scale to single-cell analysis across …

ca (code pays fourni par la source)

Intracellular calcium dynamics are predictive of T cell receptor affinity for cognate antigen

Sébastien This, Clément Playout, Solenne Lacroix, Stefanie Valbon et autres

The strength of antigen recognition by the T cell receptor (TCR) dictates T cell fate and function. However, existing biochemical, biophysical, and cell-based approaches to quantify TCR avidity for cognate antigen are limited in their ability to scale to single-cell analysis across …

ca (code pays fourni par la source)

Intracellular calcium dynamics are predictive of T cell receptor affinity for cognate antigen

Sébastien This, Clément Playout, Solenne Lacroix, Stefanie Valbon et autres

The strength of antigen recognition by the T cell receptor (TCR) dictates T cell fate and function. However, existing biochemical, biophysical, and cell-based approaches to quantify TCR avidity for cognate antigen are limited in their ability to scale to single-cell analysis across …

ca (code pays fourni par la source)

Type 1 and type 2 dendritic cell subsets cooperate to maintain intestinal immune tolerance via integrin αvβ8-mediated TGF-β activation

Sébastien This, Delphine Brichart-Vernos, Venla Anniina Väänänen, Carine Rey et autres

ABSTRACT The gastrointestinal tract is a unique immunological environment where the host must balance tolerance to commensal microbes with defense against pathogens. A critical mechanism for maintaining this balance is the peripheral conversion of naïve T cells into regulatory T cells (pTregs), …

fr, dk, us (code pays fourni par la source)

Chemotaxis overrides the killing response in alloreactive CTLs, providing vascular immune privilege during cellular rejection

Thomas Barba, Martin H. Oberbarnscheidt, G Franck, Chong Gao et autres

Graft endothelial cells (ECs) express donor alloantigens and encounter cytotoxic T lymphocytes (CTLs) but are generally spared during T cell-mediated rejection (TCMR), which predominantly affects epithelial structures. The mechanisms underlying this vascular immune privilege are unclear. Transcriptomics analyses and endothelial-mesenchymal transition assessments …

fr, us, gb (code pays fourni par la source)

Characterizing Signals Associated with the pre-TCR during T Cell Development

Andrew I. Dayton, Sébastien This, Ève Mallet Gauthier, Heather J. Melichar

Developing T cells are subjected to a gauntlet of tests in the thymus to ensure a safe and effective T cell receptor (TCR) repertoire. β-selection, a checkpoint early in T cell development, tests the functionality of rearranged TCRβ chains. Cells with functional …

ca (code pays fourni par la source)

Machine learning predictions of T cell antigen specificity from intracellular calcium dynamics

Sébastien This, Santiago Costantino, Heather J. Melichar

Adoptive T cell therapies rely on the production of T cells with an antigen receptor that directs their specificity toward tumor-specific antigens. Methods for identifying relevant T cell receptor (TCR) sequences, predominantly achieved through the enrichment of antigen-specific T cells, represent a …

ca (code pays fourni par la source)

Predicting T cell activation based on intracellular calcium fluctuations

Sébastien This, Santiago Costantino, Heather J. Melichar

Abstract Adoptive T cell therapies rely on the transduction of T cells with a predetermined antigen receptor which redirects their specificity towards tumor-specific antigens. Despite the development of multiple platforms for tumor-specific T cell receptor (TCR) discovery, this process remains time consuming …

ca (code pays fourni par la source)

Network analysis of large-scale ImmGen and Tabula Muris datasets highlights metabolic diversity of tissue mononuclear phagocytes

Anastasiia Gainullina, Denis A. Mogilenko, Li‐Hao Huang, Helena Todorov et autres

The diversity of mononuclear phagocyte (MNP) subpopulations across tissues is one of the key physiological characteristics of the immune system. Here, we focus on understanding the metabolic variability of MNPs through metabolic network analysis applied to three large-scale transcriptional datasets: we introduce …

ru, us, be, sg, fr, de, tw (code pays fourni par la source)

What’s self got to do with it: Sources of heterogeneity among naive T cells

Sébastien This, Dakota Rogers, Ève Mallet Gauthier, Judith N. Mandl et autres

T cells are largely homogeneous populations despite the extraordinary diversity of their T cell receptors (TCR). The self-immunopeptidome plays a key role in the selection of the naive T cell repertoire in the thymus, and self-peptides are also an important driver of …

ca (code pays fourni par la source)