Heather J. Melichar

GFI1 as a novel regulator of γδ T cell development and the IL-17/IFN-γ lineage commitment

Jennifer Fraszczak, David Obwegs, Kaifee Arman, Tanja Muralt et autres

GFI1 is a DNA-binding transcription factor that regulates the commitment of hematopoietic precursors to myeloid and lymphoid lineages. Here we report that GFI1 is expressed in γδ T cells and restricts the cellularity of RORγt + Vγ6 + γδ T cells that …

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Interleukin-17-Producing γδ T Cells Originate from SOX13+ Progenitors that Are Independent of γδTCR Signaling.

Nicholas A. Spidale, Katelyn Sylvia, Kavitha Narayan, Bing Miu et autres

Calibrating T cell responsiveness through interactions with self

Judith N. Mandl, Heather J. Melichar, Byron B. Au‐Yeung, Johannes Textor et autres

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GFI1 as a novel regulator of γδ T cell development and the IL-17/IFNγ lineage commitment

Jennifer Fraszczak, David Obwegs, Kaifee Arman, Tanja Muralt et autres

Abstract GFI1 is a DNA-binding zinc finger transcription factor regulating the commitment of hematopoietic precursors to myeloid and lymphoid lineages. Here we report that GFI1 is expressed in γδ T cells and restricts the cellularity of RORγt + Vγ6 + γδT cells …

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A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection

Susan Westfall, Maria E. Gentile, Tayla M. Olsen, Danielle Karo‐Atar et autres

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Unbiased analysis of NUP98-KDM5A-induced murine leukemia reveals phenotypic heterogeneity recapitulating human disease subtypes

Marilaine Fournier, Marion Dubuissez, Mathieu Neault, Jean‐Sébastien Delisle et autres

NUP98-KDM5A (NK5) is an oncogenic fusion protein implicated in the development of several types of acute myeloid leukemia (AML) in humans, including rare pediatric acute megakaryoblastic leukemia (AMKL). NK5 expression in murine hematopoietic progenitor cells can induce AML in mice. However, the …

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Characterizing Signals Associated with the pre-TCR during T Cell Development

Andrew I. Dayton, Sébastien This, Ève Mallet Gauthier, Heather J. Melichar

Developing T cells are subjected to a gauntlet of tests in the thymus to ensure a safe and effective T cell receptor (TCR) repertoire. β-selection, a checkpoint early in T cell development, tests the functionality of rearranged TCRβ chains. Cells with functional …

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Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling

Patricio Artusa, Loan Nguyen Yamamoto, Camille Barbier, Stefanie F. Valbon et autres

Central tolerance of thymocytes to self-antigen depends on the medullary thymic epithelial cell (mTEC) transcription factor autoimmune regulator (Aire), which drives tissue-restricted antigen (TRA) gene expression. Vitamin D signaling regulates Aire and TRA expression in mTECs, providing a basis for links between …

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A type 1 immune-stromal cell network mediates disease tolerance and barrier protection against intestinal infection

Susan Westfall, Maria E. Gentile, Tayla M. Olsen, Danielle Karo‐Atar et autres

SUMMARY Type 1 immunity mediates host defense through pathogen elimination, but whether this pathway also impacts tissue function is unknown. Here we demonstrate that rapid induction of IFNγ signaling coordinates a multi-cellular response that is critical to limit tissue damage and maintain …

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Type I interferon induced during chronic viral infection favors B‐cell development in the thymus

Stefanie F. Valbon, Marie‐Ève Lebel, H. Alex Feldman, Stephanie A. Condotta et autres

Chronic viral infections cause thymic involution yet the potential for broader, longer-term impact on thymic composition remains unexplored. Here we show that chronic, but not acute, lymphocytic choriomeningitis virus infection promotes a unique population of immature B cells in the thymus. We …

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A Retrospective Analysis of Leadership, Awardees, and Member Gender Representation of the Canadian Society for Immunology

Melina Messing, Dominique M. Gatti, Siavash Mashhouri, Sabryna Nantel et autres

The Canadian Society for Immunology (CSI) established a formal Equity, Diversity, and Inclusion (EDI) Committee with the goal of providing EDI advocacy and leadership within the CSI, as well as in the broader scientific community. A first task of this committee was …

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Machine learning predictions of T cell antigen specificity from intracellular calcium dynamics

Sébastien This, Santiago Costantino, Heather J. Melichar

Adoptive T cell therapies rely on the production of T cells with an antigen receptor that directs their specificity toward tumor-specific antigens. Methods for identifying relevant T cell receptor (TCR) sequences, predominantly achieved through the enrichment of antigen-specific T cells, represent a …

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