Delphine Brichart-Vernos

Author Correction: Erythropoietin receptor on cDC1s dictates immune tolerance

Xingdong Zhang, Christopher S. McGinnis, Guotao Yu, Sijie Chen et autres

us, de, fr, nl (code pays fourni par la source)

Type 1 and type 2 dendritic cell subsets cooperate to maintain intestinal immune tolerance via integrin αvβ8-mediated TGF-β activation

Sébastien This, Delphine Brichart-Vernos, Venla Anniina Väänänen, Carine Rey et autres

ABSTRACT The gastrointestinal tract is a unique immunological environment where the host must balance tolerance to commensal microbes with defense against pathogens. A critical mechanism for maintaining this balance is the peripheral conversion of naïve T cells into regulatory T cells (pTregs), …

fr, dk, us (code pays fourni par la source)

Erythropoietin receptor on cDC1s dictates immune tolerance

Xingdong Zhang, Christopher S. McGinnis, Guotao Yu, Sijie Chen et autres

us, de, fr, nl (code pays fourni par la source)

Proof of Concept of the Radiosensitizing Effect of Gadolinium Oxide Nanoparticles in Cell Spheroids and a Tumor-Implanted Murine Model of Chondrosarcoma

Marie‐Thérèse Aloy, Jacqueline Sidi Boumedine, A. Deville, David Kryza et autres

Purpose: Chondrosarcomas (CHSs), which represent 20% of primary bone tumors in adults, are mostly resistant to radio- and chemotherapy. It is therefore essential that new therapeutic approaches, targeted to the tumour, be developed to improve the prognosis of patients. The effectiveness, as …

fr (code pays fourni par la source)

New generations of metallic nanoparticles to enhance the response to radiotherapy of radioresistant and invasive cancers

Delphine Brichart-Vernos

L’utilisation de nanoparticules contenant un métal à numéro atomique élevé est une approche prometteuse pour amplifier les effets de la radiothérapie, un traitement aujourd’hui utilisé chez plus de 50 % des patients atteints d’un cancer. Parmi elles, les AGuIX®, nanoparticules aux propriétés …

fr (code pays fourni par la source)

Nouvelles générations de nanoparticules métalliques permettant d’amplifier la réponse à la radiothérapie des cancers radiorésistants et invasifs

Delphine Brichart-Vernos

L’utilisation de nanoparticules contenant un métal à numéro atomique élevé est une approche prometteuse pour amplifier les effets de la radiothérapie, un traitement aujourd’hui utilisé chez plus de 50 % des patients atteints d’un cancer. Parmi elles, les AGuIX®, nanoparticules aux propriétés …

A New Generation of Ultrasmall Nanoparticles Inducing Sensitization to Irradiation and Copper Depletion to Overcome Radioresistant and Invasive Cancers

Paul Rocchi, Delphine Brichart-Vernos, François Lux, Isabelle Morfin et autres

An emerging target to overcome cancer resistance to treatments is copper, which is upregulated in a wide variety of tumors and may be associated with cancer progression and metastases. The aim of this study was to develop a multimodal ultrasmall nanoparticle, CuPRiX, …

fr (code pays fourni par la source)

Involvement of HIF-1α in the Detection, Signaling, and Repair of DNA Double-Strand Breaks after Photon and Carbon-Ion Irradiation

Anne‐Sophie Wozny, Arnaud Gauthier, Gersende Alphonse, Céline Malésys et autres

Hypoxia-Inducible Factor 1α (HIF-1α), which promotes cancer cell survival, is the main regulator of oxygen homeostasis. Hypoxia combined with photon and carbon ion irradiation (C-ions) stabilizes HIF-1α. Silencing HIF-1α under hypoxia leads to substantial radiosensitization of Head-and-Neck Squamous Cell Carcinoma (HNSCC) cells …

fr, jp (code pays fourni par la source)