Marcela Cárdenas‐Tueme

Plasma C24:0 ceramide impairs adipose tissue remodeling and promotes liver steatosis and glucose imbalance in offspring of rats

Alberto Camacho‐Morales, Lilia Guadalupe Noriega, Adriana Sánchez‐García, Iván Torre-Villalvazo et autres

models of Wistar rats and C57BL/6 mice demonstrated that C24:0 ceramide disrupted glucose balance, and differentiation and lipid accumulation in adipocytes, whereas promoted liver steatosis. Mechanistically, C24:0 ceramide impaired mitochondrial fatty acid oxidation in adipocytes and hepatic cells, tentatively by favoring reactive …

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Drosophila in the study of hTBP protein interactions in the development and modeling of SCA17

Rubén J. Montalvo-Méndez, Marcela Cárdenas‐Tueme, Diana Reséndez‐Pérez

BACKGROUND: Protein interactions participate in many molecular mechanisms involved in cellular processes. The human TATA box binding protein (hTBP) interacts with Antennapedia (Antp) through its N-terminal region, specifically via its glutamine homopeptides. This PolyQ region acts as a binding site for other …

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Drosophila en el estudio de las interacciones proteicas de hTBP en el desarrollo y modelaje de SCA17

Rubén J. Montalvo-Méndez, Marcela Cárdenas‐Tueme, Diana Reséndez‐Pérez

Antecedentes: Las interacciones proteicas participan en una gran cantidad de mecanismos moleculares que rigen los procesos celulares. La proteína de unión a la caja TATA humana (hTBP) interacciona con Antennapedia (Antp) a través de su extremo N-terminal, específicamente a través de sus …

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Prenatal Programming of Monocyte Chemotactic Protein-1 Signaling in Autism Susceptibility

Alberto Camacho‐Morales, Marcela Cárdenas‐Tueme

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Preterm Delivery in Obese Mothers Predicts Tumor Necrosis Factor-α Levels in Breast Milk

Mario Daniel Caba‐Flores, Marcela Cárdenas‐Tueme, Rubí Viveros-Contreras, Carmen Valenzuela et autres

Background:Breast milk (BM) is a nutritive fluid that is rich in bioactive components such as hormones and cytokines that can shape the newborn's feeding habits and program the newborn's immature immune system. BM components can change under different scenarios that include maternal …

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Micro problems with macro consequences: accumulation of persistent organic pollutants and microplastics in human breast milk and in human milk substitutes

Mario Daniel Caba‐Flores, Carmen Valenzuela, Marcela Cárdenas‐Tueme, Alberto Camacho‐Morales

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Micro problems with Macro Consequences: Accumulation of Persistent Organic Pollutants and Microplastics in Human Breast Milk and in Human Milk Substitutes

Mario Daniel Caba‐Flores, Carmen Valenzuela, Marcela Cárdenas‐Tueme, Alberto Camacho‐Morales

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Modelling of human polyglutamine neurological disorders in Drosophila

Marcela Cárdenas‐Tueme, Claudia Altamirano‐Torres, Alejandra E. Arreola-Triana, Diana Reséndez‐Pérez

Polyglutamine (PolyQ) expansion diseases are a family of autosomal dominant neurodegenerative disorders that includes Huntington’s disease and spinocerebellar ataxias. These diseases are caused by an abnormal number of glutamines repeats in the affected proteins. Different in vitro and in vivo models have …

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Maternal programming by high-energy diets primes ghrelin sensitivity in the offspring of rats exposed to chronic immobilization stress

Alberto Camacho‐Morales, Andrea Caballero-Benitez, Enrique Vázquez-Cruz, Roger Maldonado‐Ruiz et autres

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Transgenerational Susceptibility to Food Addiction-Like Behavior in Rats Associates to a Decrease of the Anti-Inflammatory IL-10 in Plasma

Larisa Montalvo-Martínez, Gabriela Cruz-Carrillo, Roger Maldonado‐Ruiz, Luis A. Trujillo-Villarreal et autres

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Maternal high-dense diet programs interferon type I signaling and microglia complexity in the nucleus accumbens shell of rats showing food addiction-like behavior

Larisa Montalvo-Martínez, Gabriela Cruz-Carrillo, Roger Maldonado‐Ruiz, Marcela Cárdenas‐Tueme et autres

OBJECTIVE: This study aimed to characterize the molecular immune networks and microglia reactivity in the nucleus accumbens (NAc) shell affected by fetal nutritional programming leading to addiction-like behavior in the offspring of Wistar rats. Fetal nutritional programming by energy-dense foods leads to …

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Fornix volumetric increase and microglia morphology contribute to spatial and recognition-like memory decline in ageing male mice

Marcela Cárdenas‐Tueme, Luis A. Trujillo-Villarreal, Victor Ramı́rez-Amaya, Eduardo A. Garza‐Villarreal et autres

Ageing displays a low-grade pro-inflammatory profile in blood and the brain. Accumulation of pro-inflammatory cytokines, microglia activation and volumetric changes in the brain correlate with cognitive decline in ageing models. However, the interplay between them is not totally understood. Here, we aimed …

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