Roger Maldonado‐Ruiz

Abstract 4369459: Depressive symptoms have a differential expression in two models of heart failure

Roger Maldonado‐Ruiz, Judith Bernal‐Ramírez, Omar Lozano, Gerardo Garcia Rivas

Introduction: Patients with HFpEF present a higher prevalence of major depressive disorder MDD (13%) than patients with HFrEF (6%). Several studies report that HFpEF and depression, share proinflammatory cytokines, including IL-33, which plasma concentration has a positive correlation with left ventricle diastolic …

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Plasma C24:0 ceramide impairs adipose tissue remodeling and promotes liver steatosis and glucose imbalance in offspring of rats

Alberto Camacho‐Morales, Lilia Guadalupe Noriega, Adriana Sánchez‐García, Iván Torre-Villalvazo et autres

models of Wistar rats and C57BL/6 mice demonstrated that C24:0 ceramide disrupted glucose balance, and differentiation and lipid accumulation in adipocytes, whereas promoted liver steatosis. Mechanistically, C24:0 ceramide impaired mitochondrial fatty acid oxidation in adipocytes and hepatic cells, tentatively by favoring reactive …

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Distinguishing pathophysiological features of heart failure with reduced and preserved ejection fraction: A comparative analysis of two mouse models

Abraham Méndez‐Fernández, Ángel Fernández‐Mora, Judith Bernal‐Ramírez, Hugo Alves‐Figueiredo et autres

Heart failure (HF) is a heterogeneous condition that can be categorized according to the left ventricular ejection fraction (EF) into HF with reduced (HFrEF) or preserved (HFpEF) EF. Although HFrEF and HFpEF share some common clinical manifestations, the mechanisms underlying each phenotype …

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Maternal methyl donor supplementation regulates the effects of cafeteria diet on behavioral changes and nutritional status in male offspring

Katya Herrera, Roger Maldonado‐Ruiz, Alberto Camacho‐Morales, Ana Laura de la Garza et autres

Background: Nutritional status and maternal feeding during the perinatal and postnatal periods can program the offspring to develop long-term health alterations. Epidemiologic studies have demonstrated an association between maternal obesity and intellectual disability/cognitive deficits like autism spectrum disorders (ASDs) in offspring. Experimental …

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Maternal programming by high-energy diets primes ghrelin sensitivity in the offspring of rats exposed to chronic immobilization stress

Alberto Camacho‐Morales, Andrea Caballero-Benitez, Enrique Vázquez-Cruz, Roger Maldonado‐Ruiz et autres

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Transgenerational Susceptibility to Food Addiction-Like Behavior in Rats Associates to a Decrease of the Anti-Inflammatory IL-10 in Plasma

Larisa Montalvo-Martínez, Gabriela Cruz-Carrillo, Roger Maldonado‐Ruiz, Luis A. Trujillo-Villarreal et autres

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Maternal high-dense diet programs interferon type I signaling and microglia complexity in the nucleus accumbens shell of rats showing food addiction-like behavior

Larisa Montalvo-Martínez, Gabriela Cruz-Carrillo, Roger Maldonado‐Ruiz, Marcela Cárdenas‐Tueme et autres

OBJECTIVE: This study aimed to characterize the molecular immune networks and microglia reactivity in the nucleus accumbens (NAc) shell affected by fetal nutritional programming leading to addiction-like behavior in the offspring of Wistar rats. Fetal nutritional programming by energy-dense foods leads to …

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MCP-1 Signaling Disrupts Social Behavior by Modulating Brain Volumetric Changes and Microglia Morphology

Roger Maldonado‐Ruiz, Luis A. Trujillo-Villarreal, Larisa Montalvo-Martínez, Octavio Fabián Mercado-Gómez et autres

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Potential role of primed microglia during obesity on the mesocorticolimbic circuit in autism spectrum disorder

Luis A. Trujillo-Villarreal, Marcela Cárdenas‐Tueme, Roger Maldonado‐Ruiz, Diana Reséndez‐Pérez et autres

Autism spectrum disorder (ASD) is a complex neurodevelopmental disease which involves functional and structural defects in selective central nervous system (CNS) regions that harm function and individual ability to process and respond to external stimuli. Individuals with ASD spend less time engaging …

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Fetal Programming by Methyl Donors Modulates Central Inflammation and Prevents Food Addiction-Like Behavior in Rats

Gabriela Cruz-Carrillo, Larisa Montalvo-Martínez, Marcela Cárdenas‐Tueme, Sofía Bernal‐Vega et autres

Fetal programing by hypercaloric intake leads to food addiction-like behavior and brain pro-inflammatory gene expression in offspring. The role of methylome modulation during programming on central immune activation and addiction-like behavior has not been characterized. We employed a nutritional programming model exposing …

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Neurodegenerative Susceptibility During Maternal Nutritional Programing: Are Central and Peripheral Innate Immune Training Relevant?

Marcela Cárdenas‐Tueme, Larisa Montalvo-Martínez, Roger Maldonado‐Ruiz, Alberto Camacho‐Morales et autres

Maternal overnutrition modulates body weight, development of metabolic failure and, potentially, neurodegenerative susceptibility in the offspring. Overnutrition sets a chronic pro-inflammatory profile that integrates peripheral and central immune activation nodes, damaging neuronal physiology and survival. Innate immune cells exposed to hypercaloric diets …

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Maternal overfeeding primes ghrelin sensitivity in the hypothalamus leading to hyperphagia in the offspring

Roger Maldonado‐Ruiz, Marcela Árdenas-Tueme, Larisa Montalvo-Martínez, Román Vidaltamayo et autres

Hypothalamic glial cells named tanycytes, which line the 3rd ventricle (3V), are emerging as a key player in the hypothalamic network that controls feeding and energy balance, as they are a key component of brain-endocrine interaction.However, further studies are warranted to understand …

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