Modelling of human polyglutamine neurological disorders in Drosophila

Le résumé fourni par la source

Polyglutamine (PolyQ) expansion diseases are a family of autosomal dominant neurodegenerative disorders that includes Huntington’s disease and spinocerebellar ataxias. These diseases are caused by an abnormal number of glutamines repeats in the affected proteins. Different in vitro and in vivo models have been developed to study these diseases; in this review, we will focus on the fruit fly, Drosophila melanogaster, as a model organism to study PolyQ diseases in humans, resulting in a better understanding of PolyQ pathologies and opening avenues to potential therapeutical treatments.

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