Igor P. Beletsky

Study of the pharmacokinetics of non-immunogenic staphylokinase in patients with acute myocardial infarction and acute ischemic stroke

Сергей Витальевич Иванов, Igor P. Beletsky, Marina V. Zakharova, Э. А. Пономарев et autres

The aim. To investigate the pharmacokinetic parameters of non-immunogenic staphylokinase (Fortelyzin®, SuperGene LLC, Russia) in patients with acute myocardial infarction with ST-segment elevation (STEMI) on the electrocardiogram and in patients with ischemic stroke. Materials and methods. The clinical study was conducted in …

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Assessment of the allergenic and immunotoxic properties of the recombinant non-immunogenic staphylokinase in preclinical and clinical trials

Sergey S. Markin, Сергей Витальевич Иванов, Igor P. Beletsky, Marina V. Zakharova et autres

The aim. To study possible allergenic and immunotoxic properties of the recombinant non-immunogenic staphylokinase molecule with the amino acids replacement Lys74, Glu75 and Arg77 with alanine in preclinical and clinical studies. Materials and methods. The allergenic and immunotoxic properties of the recombinant …

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NK cell activity in the tumor microenvironment

A. V. Kuznetsova, Ksenia А. Glukhova, Igor P. Beletsky, Ivanov Aa

The formation of an immunosuppressive tumor microenvironment (TME) impairs natural killer (NK) cell infiltration and persistence within tumor tissue and significantly diminishes NK-mediated cytotoxicity. This presents a substantial barrier to the efficacy of NK cell therapy in solid tumors. Current strategies aim …

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Contemporary Approaches to Immunotherapy of Solid Tumors

A. V. Kuznetsova, Ksenia А. Glukhova, О. П. Попова, Igor P. Beletsky et autres

In recent years, the arrival of the immunotherapy industry has introduced the possibility of providing transformative, durable, and potentially curative outcomes for various forms of malignancies. However, further research has shown that there are a number of issues that significantly reduce the …

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ONC201-Induced Mitochondrial Dysfunction, Senescence-like Phenotype, and Sensitization of Cultured BT474 Human Breast Cancer Cells to TRAIL

Artem A. Mishukov, Irina V Odinokova, Ekaterina Mndlyan, M. I. Kobyakova et autres

ONC201, the anticancer drug, targets and activates mitochondrial ATP-dependent caseinolytic peptidase P (ClpP), a serine protease located in the mitochondrial matrix. Given the promise of ONC201 in cancer treatment, we evaluated its effects on the breast ductal carcinoma cell line (BT474). We …

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Recruitment of TNF ligands to lipid rafts is mediated by their physical association with caveolin‐1

Julia A. Trizna, Bogdan S. Melnik, Olga V. Proussakova, Igor P. Beletsky

Activities of the tumour necrosis factor (TNF) family members are associated with their targeting to lipid rafts, specialised regions of the plasma membrane. Herein, we investigated the physical association of TNF and its family members cluster of differentiation 40 ligand (CD40L) and …

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CRISPR editing of the GLI1 first intron abrogates GLI1 expression and differentially alters lineage commitment

Yekaterina Galat, Haigang Gu, Mariana Perepitchka, Robert T. Taylor et autres

GLI1 is one of three GLI family transcription factors that mediate Sonic Hedgehog signaling, which plays a role in development and cell differentiation. GLI1 forms a positive feedback loop with GLI2 and likely with itself. To determine the impact of GLI1 and …

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Down syndrome iPSC model: endothelial perspective on tumor development

Mariana Perepitchka, Yekaterina Galat, Igor P. Beletsky, Philip M. Iannaccone et autres

// Mariana Perepitchka 1 , 2 , Yekaterina Galat 1 , 2 , 3 , * , Igor P. Beletsky 3 , Philip M. Iannaccone 1 , 2 , 4 , 5 and Vasiliy Galat 2 , 3 , 4 , 5 …

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Dephosphorylation of Fas-ligand and caveolin-1 is a prerequisite step in Fas-ligand - caveolin-1 complex formation and cell death stimulation

Julia A. Trizna, Olga V. Proussakova, Vladimir G. Gogvadze, Igor P. Beletsky

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Impairment of Fas-ligand–caveolin-1 interaction inhibits Fas-ligand translocation to rafts and Fas-ligand-induced cell death

Julia A. Trizna, Olga V. Proussakova, Vladimir G. Gogvadze, Igor P. Beletsky

Fas-ligand/CD178 belongs to the TNF family proteins and can induce apoptosis through death receptor Fas/CD95. The important requirement for Fas-ligand-dependent cell death induction is its localization to rafts, cholesterol- and sphingolipid-enriched micro-domains of membrane, involved in regulation of different signaling complexes. Here, …

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A simple and sensitive two-tube multiplex PCR assay for simultaneous detection of ten meat species

Olga V. Prusakova, Gaida V. Afanas'eva, Y.A. Trizna, Ludmila F. Nazarova et autres

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Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria

Tamara Azarashvili, Olga V. Krestinina, Yulia L. Baburina, Irina V Odinokova et autres

The translocator protein (TSPO; 18 kDa) is a high-affinity cholesterol-binding protein located in the outer membrane of mitochondria. A domain in the C-terminus of TSPO was characterized as the cholesterol recognition/interaction amino acid consensus (CRAC). The ability of the CRAC domain to …

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