Tamara Azarashvili

Possible Involvement of 2′,3′-Cyclic Nucleotide-3′-Phosphodiesterase in the Protein Phosphorylation-Mediated Regulation of the Permeability Transition Pore

Yulia L. Baburina, Irina V Odinokova, Tamara Azarashvili, В. С. Акатов et autres

Calcium as a secondary messenger regulates the phosphorylation of several membrane-bound proteins in brain and liver mitochondria. Regulation of the activity of different protein kinases and phosphatases by Ca2+ occurs through its binding with calmodulin. The protein phosphorylation is strongly dependent on …

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Operation of the Permeability Transition Pore in Rat Heart Mitochondria in Aging

Irina V Odinokova, Yulia L. Baburina, Alexey G. Kruglov, Irina M. Santalova et autres

The functioning of the mitochondrial permeability transition pore (mPTP) is involved in the mechanism of programmed cell death and mitochondrial dysfunction observed with aging. In this work, the functional state of heart mitochondria isolated from young (mature and 2–3-month-old) and old (20–22-month-old) …

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Detection of Protein Kinase A and C Target Proteins in Rat Brain Mitochondria

Olga V. Krestinina, Irina V Odinokova, Yulia L. Baburina, Tamara Azarashvili

Phosphorylation of some membrane-bound proteins in the mitochondria of rat liver and brain is regulated by Ca 2+ and cAMP acting as secondary messengers. These proteins are the main myelin components: 46 kDa 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNP) and two isoforms of the myelin …

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Мелатонин модулирует фосфорилирование 2',3'-циклонуклеотид-3'-фосфодиэстеразы в присутствии протопорфирина IX в митохондриях мозга крыс при функционировании митохондриальной неспецифической поры, "Нейрохимия"

Olga V. Krestinina, Ю. Л. Бабурина, Irina V Odinokova, Tamara Azarashvili et autres

ФУНКЦИОНИРОВАНИЕ НЕСПЕЦИФИЧЕСКОЙ ПОРЫ В МИТОХОНДРИЯХ СЕРДЦА КРЫС РАЗНОГО ВОЗРАСТА, "Биологические мембраны: Журнал мембранной и клеточной биологии"

Irina V Odinokova, Ю. Л. Бабурина, Alexey G. Kruglov, Irina M. Santalova et autres

Melatonin Modulates Phosphorylation of 2′,3′-Cyclic Nucleotide-3′-Phosphodiesterase in the Presence of Protoporphyrin IX in the Brain Mitochondria of Rats during the Functioning of the Non-Specific Mitochondrial Pore

Olga V. Krestinina, Yulia L. Baburina, Irina V Odinokova, Tamara Azarashvili et autres

Melatonin ( N -acetyl-5-methoxytryptamine), a neuroendocrine hormone of the pineal gland, participates in the modulation of the mitochondrial nonspecific pore (mitochondrial permeability transition pore, mPTP). According to the results we obtained, protoporphyrin IX (PPIX, a ligand of the TSPO translocator protein) induces …

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The effects of isoquinoline carboxamide and melatonin on the differentiation of N1Е-115 mouse neuroblastoma cells (clone C-1300) and on the expression of the TSPO translocation protein and 2’,3’-cyclonucleotide-3’-phosphodiesterase in these cells

Olga V. Krestinina, Svetlana N. Myakisheva, Yulia L. Baburina, Р. С. Фадеев et autres

We studied the effect of isoquinoline carboxamide (PK11195) applied alone or in combination with melatonin on the differentiation of N1E-115 mouse neuroblastoma cells (clone C-1300). PK11195 is a synthetic ligand of the mitochondrial translocator protein (TSPO), which is one of the mitochondrial …

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Effect of the CRAC Peptide, VLNYYVW, on mPTP Opening in Rat Brain and Liver Mitochondria

Tamara Azarashvili, Olga V. Krestinina, Yulia L. Baburina, Irina V Odinokova et autres

The translocator protein (TSPO; 18 kDa) is a high-affinity cholesterol-binding protein located in the outer membrane of mitochondria. A domain in the C-terminus of TSPO was characterized as the cholesterol recognition/interaction amino acid consensus (CRAC). The ability of the CRAC domain to …

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2′,3′-Cyclic nucleotide 3′-phosphodiesterase as a messenger of protection of the mitochondrial function during melatonin treatment in aging

Yulia L. Baburina, Irina V Odinokova, Tamara Azarashvili, В. С. Акатов et autres

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Combined effect of G3139 and TSPO ligands on Ca2+-induced permeability transition in rat brain mitochondria

Tamara Azarashvili, Olga V. Krestinina, Yulia L. Baburina, Irina V Odinokova et autres

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Mitochondrial 2′, 3′-cyclic nucleotide 3′-phosphodiesterase (CNP) interacts with mPTP modulators and functional complexes (I–V) coupled with release of apoptotic factors

Yulia L. Baburina, Tamara Azarashvili, Dmitry Grachev, Olga V. Krestinina et autres

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Effect of melatonin on stress-induced opening of non-selective pore in mitochondria from brain of young and old rats

Olga V. Krestinina, Yulia L. Baburina, Tamara Azarashvili

Oxidative stress is the major factor affecting different organs during aging. Mitochondria are considered to be a source of endogenous oxidants, concentrations of which can be maintained at a low level by antioxidant enzymes. At present, the aging process is considered to …

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