Accès ouvert
2025
article
OpenAlex
Linshan Xie, Rong Xu, Huining Liu, Na Man et autres
The biased agonism of glucagon-like peptide-1 receptor (GLP-1R) plays a key role in the efficacy and side effects of drugs used to treat type II diabetes mellitus and obesity. Despite its therapeutic potential, the mechanisms underlying GLP-1R biased agonism remain poorly understood. …
cn
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Accès ouvert
2025
article
OpenAlex
Yang Yue, Lier Liu, Lijie Wu, Chanjuan Xu et autres
The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer …
cn, us
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Accès ouvert
2024
article
OpenAlex
Hidehiro Itonaga, Adnan K. Mookhtiar, Sarah Greenblatt, Fan Liu et autres
An important epigenetic component of tyrosine kinase signaling is the phosphorylation of histones, and epigenetic readers, writers, and erasers. Phosphorylation of protein arginine methyltransferases (PRMTs), have been shown to enhance and impair their enzymatic activity. In this study, we show that the …
us
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Accès ouvert
2023
article
OpenAlex
Glòria Mas Martín, Na Man, Yuichiro Nakata, Concepcion Martinez-Caja et autres
During emergency hematopoiesis, hematopoietic stem cells (HSCs) rapidly proliferate to produce myeloid and lymphoid effector cells, a response that is critical against infection or tissue injury. If unresolved, this process leads to sustained inflammation, which can cause life-threatening diseases and cancer. Here, …
us
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2022
article
OpenAlex
Hidehiro Itonaga, Adnan K. Mookhtiar, Sarah Greenblatt, Fan Liu et autres
Introduction Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the asymmetric dimethylation of arginine residues in histone and non-histone substrates, including transcription factors, RNA splicing factors, and the SWI/SNF chromatin remodeling complex. CARM1 has emerged as an important target in acute myeloid leukemia. We …
us, jp
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Accès ouvert
2022
preprint
OpenAlex
Hidehiro Itonaga, Adnan K. Mookhtiar, Sarah Greenblatt, Fan Liu et autres
Abstract Coactivator-associated arginine methyltransferase 1 (CARM1) is overexpressed in cancer, and it has emerged as an important target in acute myeloid leukemia and other hematologic malignancies. Janus kinase 2 (JAK2), that is activated by mutation in a variety of myeloid malignancies, can …
us
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Accès ouvert
2022
article
OpenAlex
Chuan Chen, Na Man, Glòria Mas Martín, Hidehiro Itonaga et autres
Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like receptors and nucleotide-binding and oligomerization domain-like receptors. These pathways are finely tuned via multiple mechanisms, including epigenetic regulation. It is well …
us
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Accès ouvert
2022
article
OpenAlex
Chuan Chen, Na Man, Fan Liu, Glòria Mas Martín et autres
Abstract Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like receptors and nucleotide-binding and oligomerization domain–like receptors. These pathways are finely tuned via multiple mechanisms, including epigenetic regulation. It is …
us
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Accès ouvert
2021
article
OpenAlex
Na Man, Glòria Mas Martín, Daniel Karl, Jun Sun et autres
Myelodysplastic syndromes (MDS) are hematopoietic stem and progenitor cell (HSPC) malignancies characterized by ineffective hematopoiesis and an increased risk of leukemia transformation. Epigenetic regulators are recurrently mutated in MDS, directly implicating epigenetic dysregulation in MDS pathogenesis. Here, we identified a tumor suppressor …
us
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Accès ouvert
2021
article
OpenAlex
Jun Sun, Gabriel Gaidosh, Ye Xu, Adnan K. Mookhtiar et autres
The activity of Rho family GTPase protein, RAC1, which plays important normal physiological functions, is dysregulated in multiple cancers. RAC1 is expressed in both estrogen receptor alpha (ER)-positive and ER-negative breast cancer (BC) cells. However, ER-positive BC is more sensitive to RAC1 …
us
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2020
conference-abstract
OpenAlex
Glòria Mas Martín, Na Man, Daniel Karl, Concepción Martínez et autres
To mount an effective immune response against infectious pathogens or tissue injury, hematopoietic stem cells (HSCs) increase their proliferation and production of myeloid cells, including macrophages, which destroy the pathogens and repair the damaged tissue. Proper resolution of inflammation is essential to …
us, jp
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Accès ouvert
2020
article
OpenAlex
Fan Liu, Ye Xu, Xiaoqing Lu, Pierre-Jacques Hamard et autres
Protein arginine methyltransferase 5 (PRMT5) catalyzes the symmetric di-methylation of arginine residues in histones H3 and H4, marks that are generally associated with transcriptional repression. However, we found that PRMT5 inhibition or depletion led to more genes being downregulated than upregulated, indicating …
us
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