Yang Yue

Molecular recognition at the opioid-modulating neuropeptide FF receptor 1

Man Na, Yang Yue, Kexin Xu, Ziyi Xu et autres

Man Na, Yang Yue, Kexin Xu, Ziyi Xu, Lu Zhang, Fangfang Zhou, Jolien De Neve, Steven Ballet, Fei Xu; Molecular Recognition at the Opioid-modulating Neurope

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Addition to “Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7”

Cuixia Li, Yiran Wu, Wenli Wang, Xu Lu et autres

Constitutive arrestin recruitment by orphan GPR52 via an atypical binding mode

Xi Lin, Xiaohu Wei, Ning Pu, Ling Wang et autres

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Mechanistic insights into the versatile stoichiometry and biased signaling of the apelin receptor-arrestin complex

Yang Yue, Chanjuan Xu, Lijie Wu, Man Na et autres

The apelin receptor (APJR) plays a pivotal role in regulating cardiovascular and metabolic health1,2. Understanding the mechanisms of biased agonism at APJR is crucial for drug discovery, as stimulation of the β-arrestin pathway may lead to some adverse effects3. Structural analyses of …

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Distinct transmission sites within a synapse for strengthening and homeostasis

Yang Yue, Man Ho Wong, Xiaojie Huang, Delia N. Chiu et autres

At synapses, miniature synaptic transmission forms the basic unit of evoked transmission, thought to use one canonical transmission site. Two general types of synaptic plasticity, associative plasticity to change synaptic weights and homeostatic plasticity to maintain an excitatory balance, are so far …

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Structural insights into the regulation of monomeric and dimeric apelin receptor

Yang Yue, Lier Liu, Lijie Wu, Chanjuan Xu et autres

The apelin receptor (APJR) emerges as a promising drug target for cardiovascular health and muscle regeneration. While prior research unveiled the structural versatility of APJR in coupling to Gi proteins as a monomer or dimer, the dynamic regulation within the APJR dimer …

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An H3K27la-mediated epigenetic pathway programs myofiber type and meat quality in goats

Feng Wang, Zhen Zhang, Xiaohua Zhou, Xinai Huang et autres

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A bibliometric analysis of cerebral palsy from 2003 to 2022

Yue Hua Hu, Yadan Zheng, Yang Yue, Wen‐Feng Fang et autres

Purpose This bibliometric study explores cerebral palsy (CP) research from 2003 to 2022 to reveal the topic hotspots and collaborations. Methods We retrieved studies on CP from the Web of Science Core Collection from 2003 to 2022 and then used CiteSpace and …

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The relationship between umbilical cord blood IL-22 level and infantile eczema at 42 days

Xujun Lu, Wenge Wang, Yang Wang, Chuo Huan et autres

Background The occurrence of eczema is related to helper T 22 (Th22) cytokine disorder, and Th22 mainly secretes interleukin-22 (IL-22). This study aims to investigate the predictive value of umbilical cord blood IL-22 levels on the onset of eczema in infants within …

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Structure-Based Ligand Discovery Targeting the Transmembrane Domain of Frizzled Receptor FZD7

Cuixia Li, Yiran Wu, Wenli Wang, Xu Lu et autres

Despite the essential roles of Frizzled receptors (FZDs) in mediating Wnt signaling in embryonic development and tissue homeostasis, ligands targeting FZDs are rare. A few antibodies and peptide modulators have been developed that mainly bind to the family-conserved extracellular cysteine-rich domain of …

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Structural insight into apelin receptor-G protein stoichiometry

Yang Yue, Lier Liu, Lijie Wu, Yiran Wu et autres

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Neurexin and Frizzled Intercept Axonal-Transport at Microtubule Minus-Ends to Control Synapse Formation

Santiago Balseiro-Gómez, Junhyun Park, Yang Yue, Chen Ding et autres

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