Jun Sun

Identification of the tendon/ligament stem cell in mice and humans

Lingling Hu, Jun Sun, Kyle W. Morse, Seoyeon Bok et autres

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Stem Cells From the Apical Papilla Cultured in Spheroids Spontaneously Differentiate Into Odontoblasts via N‐Cadherin Downregulation

Qin-Yao Zhang, Xiaoqian Liu, Mingzhu Liu, Jun Sun et autres

Traditional monolayer cultures of stem cells from the apical papilla (SCAP) fall short in their ability to replicate the anatomical organization of SCAP and often fail to provide high-quality SCAP suitable for dental root regeneration. This study aimed to employ agarose-based low-adhesion …

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Lumican from DESC spheroids enhances odontoblastic differentiation of SCAPs

Qin-Yao Zhang, Xiaoqian Liu, Jun Sun, Mingzhu Liu et autres

AIM: During the tooth-root elongation phase, dental epithelial stem cells (DESCs) cluster together and release various signaling molecules, facilitating the differentiation of stem cells from the apical papilla (SCAPs) into odontoblasts. This study aimed to investigate the regulatory mechanism of secretory proteins …

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TAF1 is required for fetal but not adult hematopoiesis in mice

Fan Liu, Jingyin Yue, Francesco Tamiro, Jun Sun et autres

While many sequence-specific transcription factors (TFs) have been identified as key regulators of hematopoietic stem cell (HSC) lineage determination, the function of general TFs in HSC behavior is poorly understood. To evaluate the function of the TFIID subunit TAF1 in normal hematopoiesis, …

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Deep Learning-Based Automated Detection of Oral Leukoplakia in Clinical Imaging

Duo Li, Xiangjian Wang, Jingwen Liu, Jun Sun

OBJECTIVE: This study aims to develop and validate a deep learning-based system for automated identification of oral leukoplakia (OLK), addressing diagnostic challenges in clinical practice. METHODS: We conducted a comparative analysis of 19 convolutional neural network (CNN) architectures using 446 clinical images …

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Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity

Hidehiro Itonaga, Adnan Kasim Mookhtiar, Sarah Merin Greenblatt, Fan Liu et autres

An important epigenetic component of tyrosine kinase signaling is the phosphorylation of histones, and epigenetic readers, writers, and erasers. Phosphorylation of protein arginine methyltransferases (PRMTs), have been shown to enhance and impair their enzymatic activity. In this study, we show that the …

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Arginine Methylation of BRD4 By CARM1 Regulates Its Function in AML

Adnan Kasim Mookhtiar, Hidehiro Itonaga, Sarah Merin Greenblatt, Concepción Martínez et autres

Acute myeloid leukemia (AML) is generally an aggressive and lethal malignancy characterized by the accumulation of immature myeloid cells in the bone marrow and peripheral blood. We have previously shown the dependence of AML, but not normal hematopoiesis, on the presence of …

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TAF1, the Largest Subunit of Tfiid, Is Dispensable for Adult Hematopoiesis

Fan Liu, Jingyin Yue, Francesco Tamiro, Jun Sun et autres

Temporal and spatial control of gene expression is central to normal hematopoietic stem cell (HSC) biology. Many sequence-specific transcription factors have been identified as key regulators of HSC fate decision, while the function of general transcription factors in HSC behavior is poorly …

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Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity in Myeloid Neoplasms with Hyperactivated JAK2

Hidehiro Itonaga, Adnan Kasim Mookhtiar, Sarah Merin Greenblatt, Fan Liu et autres

Introduction Coactivator-associated arginine methyltransferase 1 (CARM1) catalyzes the asymmetric dimethylation of arginine residues in histone and non-histone substrates, including transcription factors, RNA splicing factors, and the SWI/SNF chromatin remodeling complex. CARM1 has emerged as an important target in acute myeloid leukemia. We …

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Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity

Hidehiro Itonaga, Adnan Kasim Mookhtiar, Sarah Merin Greenblatt, Fan Liu et autres

Abstract Coactivator-associated arginine methyltransferase 1 (CARM1) is overexpressed in cancer, and it has emerged as an important target in acute myeloid leukemia and other hematologic malignancies. Janus kinase 2 (JAK2), that is activated by mutation in a variety of myeloid malignancies, can …

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Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer.

Chuan Chen, Na Man, Glòria Mas Martín, Hidehiro Itonaga et autres

Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like receptors and nucleotide-binding and oligomerization domain-like receptors. These pathways are finely tuned via multiple mechanisms, including epigenetic regulation. It is well …

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Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer

Chuan Chen, Na Man, Fan Liu, Glòria Mas Martín et autres

Abstract Innate immune cells participate in the detection of tumor cells via complex signaling pathways mediated by pattern-recognition receptors, such as Toll-like receptors and nucleotide-binding and oligomerization domain–like receptors. These pathways are finely tuned via multiple mechanisms, including epigenetic regulation. It is …

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