Accès ouvert
2025
article
OpenAlex
Diana D. Villarreal, Jessica Pérez, Mikhaela Cielo, James D. Homans et autres
BACKGROUND: Congenital syphilis rates are rising in the United States and globally, necessitating standardized care for infants born to mothers with syphilis. The Centers for Disease Control recommends comprehensive evaluation, treatment, and follow-up for these infants to ensure optimal outcomes. LOCAL PROBLEM: …
us, au
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Accès ouvert
2025
article
OpenAlex
Diana D. Villarreal, Katherine Lewis, Mikhaela Cielo, Jeffrey David Klausner
BACKGROUND: Congenital syphilis (CS) in the United States increased 10-fold in the last decade. At a large public hospital in Los Angeles, the numbers of infants born to mothers with untreated syphilis during pregnancy have continued to rise. METHODS: We compiled a …
us
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Accès ouvert
2025
article
OpenAlex
Diana D. Villarreal, Katherine Lewis, Mikhaela Cielo, Jeffrey David Klausner
Abstract Background Congenital syphilis cases in the United States have increased 10-fold in the last decade. At Los Angeles General Medical Center (LAGMC), a large public hospital in Los Angeles, infants born to mothers with untreated syphilis during pregnancy continue to rise. …
us
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Accès ouvert
2024
article
OpenAlex
Matthew S. Kelly, Coleen K. Cunningham, Elizabeth J. McFarland, Mark J Giganti et autres
Background: Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory illness among young children. Human immunodeficiency virus (HIV)-exposed, uninfected (HEU) children experience a higher burden of RSV disease and have immune abnormalities that may influence their responses to live-attenuated …
us
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2024
article
OpenAlex
Jane Q. Huang, Rowena G. Cayabyab, Mikhaela Cielo, Rangasamy Ramanathan
BACKGROUND: Ventilator-associated pneumonia (VAP) is a common hospital-acquired infection in neonates on invasive mechanical ventilation, resulting in high morbidity and mortality. The objective of this study is to determine the incidence, risk factors, short-term outcomes and microbiome associated with VAP in very-low-birth-weight …
us
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Accès ouvert
2022
article
OpenAlex
Coleen K. Cunningham, Ruth A. Karron, Petronella Muresan, Matthew S. Kelly et autres
BACKGROUND: This United States-based study compared 2 candidate vaccines: RSV/ΔNS2/Δ1313/I1314L, attenuated by NS2 gene-deletion and temperature-sensitivity mutation in the polymerase gene; and RSV/276, attenuated by M2-2 deletion. METHODS: RSV-seronegative children aged 6-24 months received RSV/ΔNS2/Δ1313/I1314L (106 plaque-forming units [PFU]), RSV/276 (105 PFU), …
us
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Accès ouvert
2020
article
OpenAlex
Kristina M. Brooks, Jeremiah D. Momper, Mauricio Pinilla, Alice Marie Stek et autres
OBJECTIVE: To evaluate the pharmacokinetics of tenofovir alafenamide (TAF) 10 mg with cobicistat and 25 mg without boosting in pregnant and postpartum women with HIV and to characterize TAF placental transfer and infant washout pharmacokinetics. DESIGN: Open-label, multicenter phase IV prospective study …
us, pr, th
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Accès ouvert
2020
article
OpenAlex
Elizabeth J. McFarland, Ruth A. Karron, Petronella Muresan, Coleen K. Cunningham et autres
BACKGROUND: Respiratory syncytial virus (RSV) is the leading viral cause of severe pediatric respiratory illness, and vaccines are needed. Live RSV vaccine D46/NS2/N/ΔM2-2-HindIII, attenuated by deletion of the RSV RNA regulatory protein M2-2, is based on previous candidate LID/ΔM2-2 but incorporates prominent …
us
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Accès ouvert
2019
article
OpenAlex
Elizabeth J. McFarland, Ruth A. Karron, Petronella Muresan, Coleen K. Cunningham et autres
BACKGROUND: The safety and immunogenicity of live respiratory syncytial virus (RSV) candidate vaccine, LID/ΔM2-2/1030s, with deletion of RSV ribonucleic acid synthesis regulatory protein M2-2 and genetically stabilized temperature-sensitivity mutation 1030s in the RSV polymerase protein was evaluated in RSV-seronegative children. METHODS: Respiratory …
us
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Accès ouvert
2019
conference-abstract
OpenAlex
Thomas M Tarro, Susan Bulter-Wu, Andrea Kovács, Mikhaela Cielo
Abstract Background Lower respiratory tract infection (LRTI) has high mortality among critically ill patients. The current standard of care for diagnosing bacterial causes of LRTI is respiratory culture, which is time consuming and insensitive. The FilmArray Pneumonia Panel (FA-Pneumo) (Biofire Diagnostics, Salt …
us
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Accès ouvert
2018
article
OpenAlex
Elizabeth J. McFarland, Ruth A. Karron, Petronella Muresan, Coleen K. Cunningham et autres
Background: Live respiratory syncytial virus (RSV) candidate vaccine LIDΔM2-2 is attenuated by deletion of the RSV RNA regulatory protein M2-2, resulting in upregulated viral gene transcription and antigen expression but reduced RNA replication. Methods: RSV-seronegative children ages 6-24 months received a single …
us
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Accès ouvert
2011
article
OpenAlex
Feng-Ying C. Lin, Leonard E. Weisman, Parvin H. Azimi, Amy E. Young et autres
BACKGROUND: Most early-onset group B streptococcal (GBS) disease in recent years has occurred in newborns of prenatally GBS-negative mothers who missed intrapartum antibiotic prophylaxis (IAP). We aimed to assess the accuracy of prenatal culture in predicting GBS carriage during labor, the IAP …
us, ca
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