Ruilong Sheng

Experimental and computational study on the properties of a synthesized luminescent neutral Cu(I) complex with diphosphine and diimine ligands

Xiaojuan Sun, Ruilong Sheng, Maciej Spiegel, Zhiqiang Wang

cn, pt, pl (code pays fourni par la source)

Synthesis and evaluation of coumarin derivatives as potential anticancer therapies for colon cancer: In vitro antiproliferation, cell cycle arrest analyses, network pharmacology investigations, and molecular docking studies

J. Y. Zhao, Lin Xing, Wan Shun Wang, Kai Zhu et autres

cn, pt (code pays fourni par la source)

Biocompatible thermal shape-memory poly(lactide- co -trimethylene carbonate) elastomers for cell culture scaffold application

Shihao Zhang, Xu Li, Dong Zhou, Wei Luo et autres

: 41.54-10.14 °C) enable their programmable thermal shape-memory function. Moreover, the introduction of TMCs could alleviate local acid degradation of PDLLA, improve the hydrophilicity (water contact angle reduced from 97.75° to 62.25°), and maintain excellent cytocompatibility (meet the medical grade standard). The …

cn, pt (code pays fourni par la source)

USP43 Promotes Colorectal Cancer Progression by Enhancing Wnt/β-catenin Signaling Pathway

D. Li, Fanghao Yang, Dalong Ma, Wei Li et autres

Abstract Wnt/β-catenin signaling is a cellular signaling pathway that plays a crucial role in various biological processes, including embryonic development, cell differentiation, and tissue homeostasis. And, its imbalance is closely linked to tumorigenesis. Here, we report USP43, a deubiquitinase, as a positive …

cn (code pays fourni par la source)

A weaker adversarial neural networks method for linear second order elliptic PDEs

Ruilong Sheng, Jerry Zhijian Yang, Juntao You, Cheng Yuan

cn (code pays fourni par la source)

Tocopherol–Doxorubicin Conjugate as a Lipid–Prodrug: Synthetic Methods, Self-Assembly, Breast Cancer Cell Inhibition, and Theoretical Analysis

Lara Caires, Dina Maciel, Rita Castro, Mara Gonçalves et autres

Developing natural lipid-based conjugates/prodrugs has emerged as a promising topic in pharmaceutical chemistry and biomedicine. In this work, a natural antioxidant lipid, α-tocopherol (vitamin E), was covalently connected with doxorubicin (Dox) to synthesize a Toco–Dox conjugate through two approaches: triphosgene activation (method …

pt, pl (code pays fourni par la source)

Novel Yunaconitine Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors and Radical Scavenger: Design, Synthesis, in Vitro Cellular Evaluation, and Molecular Docking Study

Enxiao Wang, Lin Xing, Lulu Li, Meidi Deng et autres

Diabetes and oxidative stress are serious threats to human health and well-being. Protein tyrosine phosphatase 1B (PTP1B) and oxidative stress are important targets for managing diabetes. In this work, a series of new Yunaconitine derivatives (1-25) were synthesized and characterized; their inhibitory …

cn, pt (code pays fourni par la source)

Advanced optical organohydrogel for rapid, sensitive and visual detection of explosive ethylenediamine

Xiaoxin Hu, Huan Ye, Beitong Zhu, Ruilong Sheng et autres

cn, pt (code pays fourni par la source)

Engineered self-assembly of plant proteins into α-ketoglutarate-loaded nanoplatforms for osteoarthritis treatment

Fei Xue, Ruilong Sheng, Qian Wang, Yuan Wang et autres

cn, jp, fr (code pays fourni par la source)

Progress of ERK Pathway-Modulated Natural Products for Anti-Non-Small-Cell Lung Cancer Activity

Chi Zhang, Jieying Yuan, Kai Zhu, Helena Tomás et autres

In recent decades, there has been a significant increase in new lung cancer cases and deaths globally, especially in China, which hindered the extension of human life expectancy and severely threatened public health. Natural products are important and sustainable sources of new …

cn, pt, us (code pays fourni par la source)

Study on the Performance and Service Life Prediction of Corrosion-Resistant Concrete Cut-Corner Square Piles

Ruilong Sheng, Kang Wang, Hua Zhen Wei, Hao Lu et autres

This paper addresses the issue of reduced lifespan of coastal concrete piles due to chloride ion corrosion. A combination of concrete mix optimization and pile geometry improvement measures is proposed. Based on the diffusion coefficient optimization of Fick’s second law, the service …

cn, jp (code pays fourni par la source)

TrialCompass: Visual Analytics for Enhancing the Eligibility Criteria Design of Clinical Trials

Ruilong Sheng, Xingbo Wang, Jiachen Wang, Xiaofu Jin et autres

Eligibility criteria play a critical role in clinical trials by determining the target patient population, which significantly influences the outcomes of medical interventions. However, current approaches for designing eligibility criteria have limitations to support interactive exploration of the large space of eligibility …