Lulu Li

Identification and Functional Analysis of a Novel NSD2 Missense Variant in a Patient With Rauch‐Steindl Syndrome

Shixuan Xu, Guoqaing Li, Yimin He, Yiyao Chen et autres

BACKGROUND: Rauch-Steindl syndrome (RAUST) is a rare neurodevelopmental disorder caused by pathogenic variants in NSD2, a histone methyltransferase gene at 4p16.3. Due to phenotypic overlap with Wolf-Hirschhorn syndrome (WHS), RAUST is often misdiagnosed. Missense variants in NSD2 are particularly challenging to interpret …

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Novel Yunaconitine Derivatives as Protein Tyrosine Phosphatase 1B Inhibitors and Radical Scavenger: Design, Synthesis, in Vitro Cellular Evaluation, and Molecular Docking Study

Enxiao Wang, Lin Xing, Lulu Li, Meidi Deng et autres

Diabetes and oxidative stress are serious threats to human health and well-being. Protein tyrosine phosphatase 1B (PTP1B) and oxidative stress are important targets for managing diabetes. In this work, a series of new Yunaconitine derivatives (1-25) were synthesized and characterized; their inhibitory …

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Microbe Engineering of Drimane-type Building Blocks for Chiral Pool Synthesis of Meroterpenoids

Wenyu Du, Zhongyu Cheng, Xingming Pan, Chenhao Liu et autres

Drimane-type merosesquiterpenoids (DMTs) are a class of natural products with diverse structures and broad biological activities. Classical DMT synthesis relies on atom-inefficient plant-derived chiral pool building blocks, while alternative drimane-type building blocks like drimenol and albicanol offer more direct routes but face …

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Kinetic Resolution of Azaarylethynyl Tertiary Alcohols by Chiral Brønsted Acid Catalysed Phosphine‐Mediated Deoxygenation

Guanghui Wang, Lulu Li, Yifeng Jiang, Xiaowei Zhao et autres

Abstract A chiral Brønsted acid catalysed phosphine‐mediated deoxygenation protocol is reported. This metal‐free method provides a precise kinetic resolution platform for azaarylethynyl tertiary alcohols, which are a broad category of biologically and synthetically important azaarene derivatives. In addition to providing an efficient …

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Kinetic Resolution of Azaarylethynyl Tertiary Alcohols by Chiral Brønsted Acid Catalysed Phosphine‐Mediated Deoxygenation

Guanghui Wang, Lulu Li, Yifeng Jiang, Xiaowei Zhao et autres

Abstract A chiral Brønsted acid catalysed phosphine‐mediated deoxygenation protocol is reported. This metal‐free method provides a precise kinetic resolution platform for azaarylethynyl tertiary alcohols, which are a broad category of biologically and synthetically important azaarene derivatives. In addition to providing an efficient …

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Direct Affinity-Immobilized Phenolic Acid Decarboxylase by a Linker Peptide on Zeolite for Efficient Bioconversion of Ferulic Acid into 4-Vinylguaiacol

Lulu Li, Liangkun Long, Shaojun Ding

4-Vinylguaiacol (4-VG) is a promising aromatic compound widely used in food, cosmetic, pharmaceutical, and chemical industries. Developing a competitive and sustainable biosynthesis method for large-scale production of 4-VG is still a great challenge because of the toxicity of 4-VG and the precursor …

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A novel surface-enhanced Raman scattering-based ratiometric approach for detection of hyaluronidase in urine

Yanmei Si, Lulu Li, Binsheng He, Jishan Li

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Bioproduction of High-Concentration 4-Vinylguaiacol Using Whole-Cell Catalysis Harboring an Organic Solvent-Tolerant Phenolic Acid Decarboxylase From Bacillus atrophaeus

Lulu Li, Liangkun Long, Shaojun Ding

The compound 4-vinyl guaiacol (4-VG) is highly valued and widely applied in the pharmaceutical, cosmetic, and food industries. The bioproduction of 4-VG from ferulic acid (FA) by nonoxidative decarboxylation using phenolic acid decarboxylases is promising but has been hampered by low conversion …

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Functional Autodisplay of Phenolic Acid Decarboxylase using a GDSL Autotransporter on Escherichia coli for Efficient Catalysis of 4-Hydroxycinnamic Acids to Vinylphenol Derivatives

Lulu Li, Xiang Wu, Liangkun Long, Shaojun Ding

Bioproduction of vinylphenol derivatives, such as 4-vinylguaiacol (4-VG) and 4-vinylphenol (4-VP), from 4-hydroxycinnamic acids, such as ferulic acid (FA) and p-coumaric acid (pCA), employing whole cells expressing phenolic acid decarboxylases (PAD) as a biocatalyst has attracted much attention in recent years. However, …

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Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions

Lulu Li, Ding Du, Jin Song, Zhi‐Yong Han et autres

Abstract A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1‐ammonium enolates for the subsequent asymmetric cascade reactions through the combination of …

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Catalytic Generation of C1 Ammonium Enolates from Halides and CO for Asymmetric Cascade Reactions

Lulu Li, Ding Du, Jin Song, Zhi‐Yong Han et autres

A general strategy for the design of asymmetric cascade reactions using readily available halides and carbon monoxide (CO) as substrates is developed. The key is the catalytic generation of C1-ammonium enolates for the subsequent asymmetric cascade reactions through the combination of palladium-catalyzed …

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Oligonucleotide Cross-Linked Hydrogel for Recognition and Quantitation of MicroRNAs Based on a Portable Glucometer Readout

Yanmei Si, Lulu Li, Ningning Wang, Jing Zheng et autres

A novel sensing platform for recognition and quantification of target microRNAs (miRNAs) was developed by combining an amylase-trapped DNA hydrogel, multicomponent nucleic acid enzymes (MNAzymes), and a portable glucometer (PGM) readout. First, the amylase was encapsulated inside the DNA hydrogel and physically …

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