Fanghao Yang

Integration of Proteomics and Phenomics to Reveal Molecular Differences in High and Low Semen Quality in Donkeys

Chen Ma, YiZaiTiGuLi ReYiMuJiang, Yajun Guo, Siyu Chang et autres

, p < 0.05). Proteomic analysis identified 6 differentially abundant proteins in seminal plasma (SPINKL, HSP-1, GBA2) and sperm (PAFAH1B1, SSMEM1, SPINK2), whose abundances showed potential associations with semen-quality traits and reproductive-organ biometry. The Spearman rank correlation analysis showed that GBA2 abundance …

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USP43 Promotes Colorectal Cancer Progression by Enhancing Wnt/β-catenin Signaling Pathway

D. Li, Fanghao Yang, Dalong Ma, Wei Li et autres

Abstract Wnt/β-catenin signaling is a cellular signaling pathway that plays a crucial role in various biological processes, including embryonic development, cell differentiation, and tissue homeostasis. And, its imbalance is closely linked to tumorigenesis. Here, we report USP43, a deubiquitinase, as a positive …

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Trim45: An emerging E3 ubiquitin ligases in cancer

Huhu Zhang, Xinping He, Lina Yang, Fanghao Yang et autres

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STING agonists: a range of eminent mediators in cancer immunotherapy

Ziyuan Wen, Fulin Sun, Ruixuan Wang, Wenbo Wang et autres

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UBA protein family: An emerging set of E1 ubiquitin ligases in cancer—A review

Huhu Zhang, Fulin Sun, Hongyu Cao, Lina Yang et autres

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Structural and molecular dysfunctions in granulosa cells: A key contributor to porcine follicular atresia

Yajun Guo, Man Chen, Shiwei Wang, Xuan Wu et autres

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New Insights into Mitochondria in Health and Diseases

Ya Li, Huhu Zhang, Chunjuan Yu, Xiaolei Dong et autres

Mitochondria are a unique type of semi-autonomous organelle within the cell that carry out essential functions crucial for the cell's survival and well-being. They are the location where eukaryotic cells carry out energy metabolism. Aside from producing the majority of ATP through …

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USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway

Shuang Li, Lina Yang, Xiaoyan Ding, Hongxiao Sun et autres

The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear. According to our research, USP32 was strongly expressed in NSCLC cell lines and …

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USP32 facilitates non-small cell lung cancer progression via deubiquitinating BAG3 and activating RAF-MEK-ERK signaling pathway

双 李, Lina Yang, Xiaoyan Ding, Hongxiao Sun et autres

Abstract The regulatory significance of ubiquitin-specific peptidase 32 (USP32) in tumor is significant, nevertheless, the biological roles and regulatory mechanisms of USP32 in non-small cell lung cancer (NSCLC) remain unclear. According to our research, USP32 was strongly expressed in NSCLC cell lines …

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Bufalin targeting CAMKK2 inhibits the occurrence and development of intrahepatic cholangiocarcinoma through Wnt/β-catenin signal pathway

Huhu Zhang, Xiaolei Dong, Xiaoyan Ding, Guoxiang Liu et autres

Abstract Background Intrahepatic cholangiocarcinoma (ICC) accounts for about 15% of primary liver cancer, and the incidence rate has been rising in recent years. Surgical resection is the best treatment for ICC, but the 5-year survival rate is less than 30%. ICC signature …

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USP32 deubiquitinase: cellular functions, regulatory mechanisms, and potential as a cancer therapy target

Shuang Li, Yang Song, Kexin Wang, Guoxiang Liu et autres

An essential protein regulatory system in cells is the ubiquitin-proteasome pathway. The substrate is modified by the ubiquitin ligase system (E1-E2-E3) in this pathway, which is a dynamic protein bidirectional modification regulation system. Deubiquitinating enzymes (DUBs) are tasked with specifically hydrolyzing ubiquitin …

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Bufalin targeting BFAR inhibits the occurrence and metastasis of gastric cancer through PI3K/AKT/mTOR signal pathway

Guang Chen, Huhu Zhang, Hongxiao Sun, Xiaoyan Ding et autres

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