Morris Keller

Potential benefits of Malva sylvestris in treating dry-eye pathology in vitro

Alexander Areesanan, Sven Nicolay, Morris Keller, Amy Marisa Zimmermann-Klemd et autres

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Antifungal Potential of Carnosic Acid from Salvia somalensis against Phytopathogenic Fungi

Valeria Iobbi, M. Lo Vetere, Anna Paola Lanteri, Jakob Klaus Reinhardt et autres

The aims of the present study were (i) to characterize the dichloromethane extract of the fresh aerial parts of S. somalensis, cultivated in Liguria (Italy), (ii) to quantify carnosic acid production and (iii) to find an eco-friendly alternative approach to control diseases …

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Potential benefits of Malva sylvestris in dry-eye disease pathology in vitro based on antioxidant, wound-healing and anti-inflammatory properties

Alexander Areesanan, Sven Nicolay, Morris Keller, Amy Marisa Zimmermann-Klemd et autres

Dry eye disease (DED) is a common chronic ocular surface disease. Available therapies are effective but often associated with side effects. This study investigates the potential of a Malva sylvestris L. flower extract and two defined preparations, a mucilage and a polyphenol …

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New neo-clerodane diterpenes from Teucrium polium subsp. capitatum

Morris Keller, Sarra Chabane, Ombeline Danton, Alessandro Prescimone et autres

Teucrium polium subsp. capitatum (syn. Teucrium capitatum , Lamiaceae), popularly known as golden or felty germander, is a deciduous shrub that abundantly grows in Mediterranean regions of Europe, Northern Africa and Southwest Asia. The aerial parts are traditionally used in Algeria as …

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CCDC 2236028: Experimental Crystal Structure Determination

Morris Keller, Sarra Chabane, Amel Boudjelal, Ombeline Danton et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

New neo-clerodane diterpenes from Teucrium polium subsp. capitatum

Morris Keller, Sarra Chabane, Amel Boudjelal, Ombeline Danton et autres

Phytochemical investigation of a methanolic extract from the aerial parts of Teucrium polium subsp. capitatum afforded six acetoxylated neo-clerodane diterpenes, including 20-acetylauropolin and 6-acetylteucjaponin A, along with four previously undescribed congeners. The compounds were isolated by a combination of silica gel column …

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Aryltetralin lignans from Hyptis brachiata inhibiting T lymphocyte proliferation

Morris Keller, Moritz Winker, Amy Marisa Zimmermann-Klemd, Nino Sperisen et autres

Increased activation and proliferation of T lymphocytes plays an essential role in the development of chronic inflammation and autoimmune diseases. Currently used immunosuppressive drugs often do not provide long-lasting relief of symptoms and show a gradual loss of efficacy over time, and …

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Polyacetylenic caffeoyl amides from Ammodaucus leucotrichus

Ahmed Hajib, Ombeline Danton, Morris Keller, Olivier Potterat et autres

Six undescribed polyacetylenic caffeoyl amides, five known flavones and three known lignans were obtained from the fruits of the North African traditional medicinal plant Ammodaucus leucotrichus Coss. & Durieu (Apiaceae). Isolation was achieved by a combination of chromatographic methods, and structures were …

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Combining Activity Profiling with Advanced Annotation to Accelerate the Discovery of Natural Products Targeting Oncogenic Signaling in Melanoma

Tanja Hell, Adriano Rutz, Lara Dürr, Maciej Dobrzyński et autres

The discovery of bioactive natural products remains a time-consuming and challenging task. The ability to link high-confidence metabolite annotations in crude extracts with activity would be highly beneficial to the drug discovery process. To address this challenge, HPLC-based activity profiling and advanced …

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Saponins from Saffron Corms Inhibit the Gene Expression and Secretion of Pro-Inflammatory Cytokines

Morris Keller, Sarah C. Fankhauser, Noreen Giezendanner, Michelle König et autres

Corms are obtained as a byproduct during the cultivation of saffron ( Crocus sativus ). In a project aimed at the valorization of this waste product, we observed that a 70% EtOH extract of the corms and a sugar-depleted MeOH fraction of …

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Teucrium polium - wound healing potential, toxicity and polyphenolic profile

Sarra Chabane, Amel Boudjelal, Morris Keller, Sara Doubakh et autres

The wound healing properties of Teucrium polium L., a plant used in the Algerian traditional medicine for the treatment of wounds, have been investigated using an excision wound model in rabbits. An ointment was prepared with two concentrations (5 and 10%) of …

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Structure-Elucidating Total Synthesis of the (Polyenoyl)tetramic Acid Militarinone C

Christian Drescher, Morris Keller, Olivier Potterat, Matthias O. Hamburger et autres

The (polyenoyl)tetramic acid militarinone C ( 1 ) heads a family of seven members. Before our work, the configuration of C-5 was unknown whereas the configurations of C-8′ and C-10′ were either ( R, R ) or ( S, S ). We …

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