Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection
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Le résumé fourni par la source
Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SARS-CoV-2-induced myocardial injury. Histological examination of cardiac tissue from 29 deceased COVID-19 patients revealed pronounced immune infiltration, cardiomyocyte necrosis, and fibrotic remodeling. To gain new insights into these pathological processes, we first analyzed 42 transcriptomes from SARS-CoV-2-infected cardiomyocytes, including primary human, iPSC, and hESC-derived cells. We identified 871 differentially expressed genes (DEGs) in infected cardiomyocytes associated with immune activation, extracellular matrix (ECM) remodeling, and impaired contractile function. Based on these dysregulated genes, we then inferred miRNA–mRNA regulatory networks and, through miRTarBase analysis, we uncovered 331 miRNAs as putative regulators of these DEGs, including miR-29a, miR-145, and miR-199a, known to modulate fibrosis, ECM composition, and cardiomyocyte survival. Finally, selected candidates were evaluated in blood samples from COVID-19 patients. We profiled circulating miRNAs in plasma from COVID-19 patients and detected 32 dysregulated miRNAs, 11 of which overlapped with the predicted set. Notably, downregulation of miR-29a correlated with profibrotic signatures, while immune-regulatory miR-21 was upregulated in mild disease. Together, our multi-modal analysis reveals a miRNA-mRNA regulatory program orchestrating inflammation, fibrosis, and contractile dysfunction in the SARS-CoV-2-infected heart. These findings highlight molecular candidates for risk stratification and therapeutic targeting in COVID-19-associated cardiomyopathy.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection
- Date Crossref
- 13/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Universidade de São Paulo pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal de Alfenas pays non établi dans la noticeUniversité ou école supérieure
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Universidade Estadual Paulista (Unesp) pays non établi dans la noticeUniversité ou école supérieure
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Universidade Federal do Rio Grande do Norte pays non établi dans la noticeUniversité ou école supérieure
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Beneficência Portuguesa de São Paulo pays non établi dans la noticeOrganisation à but non lucratif
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University of São Paulo Department of Cell and Developmental Biology pays non établi dans la noticeUniversité ou école supérieure
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School of Pharmaceutical Sciences Department of Clinical and Toxicological Analyses pays non établi dans la noticeUniversité ou école supérieure
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São Paulo State University Department of Pathology pays non établi dans la noticeUniversité ou école supérieure
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DO’R Institute for Research pays non établi dans la noticeStructure de recherche
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Federal University of Rio Grande do Norte Bioinformatics Multidisciplinary Environment pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Medicine Laboratory of Genetics and Molecular Cardiology pays non établi dans la noticeUniversité ou école supérieure
Universidade de São Paulo, Universidade Federal de Alfenas et Universidade Estadual Paulista (Unesp), avec 8 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.