Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection
Paula Paccielli Freire, Dennyson Leandro M. Fonseca, Letícia Oliveira Lopes, Ivana Silva Ferreira et autres
Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SARS-CoV-2-induced myocardial injury. Histological examination of cardiac tissue …
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npj Systems Biology and Applications