Mário Hiroyuki Hirata

ADRB3, LEPR, FTO and PPARG variants contribute to obesity-related metabolic syndrome in Brazilian adults: a polygenic risk score approach

Tamiris Invencioni Moraes Stefani, Thiago Dominguez Crespo Hirata, Álvaro Cerda, Raquel Oliveira et autres

Abstract Objective Polymorphisms in genes involved in obesity-related metabolic pathways are associated with metabolic syndrome (MetS). We hypothesized that variants in FTO, LEP, LEPR, ADRB3, ADIPOQ , TCF7L2 , ENPP1 , APOA5, PPARG , and CYP11B2 are associated with MetS and obesity-related …

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Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection

Paula Paccielli Freire, Dennyson Leandro M. Fonseca, Letícia Oliveira Lopes, Ivana Silva Ferreira et autres

Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SARS-CoV-2-induced myocardial injury. Histological examination of cardiac tissue …

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Immune checkpoint inhibitors in people living with HIV and cancer: a Kaplan–Meier-derived individual patient data meta-analysis

Francisco Cézar Aquino de Moraes, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Gustavo Tadeu Freitas Uchôa Matheus et autres

Antiretroviral therapy has enabled people living with HIV (PLWH) to achieve near-normal life expectancy, but non-AIDS-defining cancers are increasingly frequent. Immune checkpoint inhibitors (ICIs) may be effective in this population, although evidence remains limited because PLWH have often been excluded from trials. …

Immune checkpoint inhibitors in people living with HIV and cancer: a Kaplan–Meier-derived individual patient data meta-analysis

Francisco Cézar Aquino de Moraes, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Gustavo Tadeu Freitas Uchôa Matheus et autres

Antiretroviral therapy has enabled people living with HIV (PLWH) to achieve near-normal life expectancy, but non-AIDS-defining cancers are increasingly frequent. Immune checkpoint inhibitors (ICIs) may be effective in this population, although evidence remains limited because PLWH have often been excluded from trials. …

Immune checkpoint inhibitors in people living with HIV and cancer: a Kaplan–meier-derived individual patient data meta-analysis

Francisco Cézar Aquino de Moraes, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Gustavo Tadeu Freitas Uchôa Matheus et autres

Antiretroviral therapy has enabled people living with HIV (PLWH) to achieve near-normal life expectancy, but non-AIDS-defining cancers are increasingly frequent. Immune checkpoint inhibitors (ICIs) may be effective in this population, although evidence remains limited because PLWH have often been excluded from trials. …

Immune checkpoint inhibitors in people living with HIV and cancer: a Kaplan–Meier-derived individual patient data meta-analysis

Francisco Cézar Aquino de Moraes, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva, Gustavo Tadeu Freitas Uchôa Matheus et autres

Introduction Antiretroviral therapy has enabled people living with HIV (PLWH) to achieve near-normal life expectancy, but non-AIDS-defining cancers are increasingly frequent. Immune checkpoint inhibitors (ICIs) may be effective in this population, although evidence remains limited because PLWH have often been excluded from …

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Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis

Francisco Cézar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva et autres

Gastric cancer (GC) remains the fifth most common and lethal cancer worldwide, often diagnosed at advanced stages, with limited treatment options and poor survival. Beyond established risk factors, the ABO blood group system has been suggested as a potential prognostic factor, but …

Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis

Francisco Cézar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva et autres

Gastric cancer (GC) remains the fifth most common and lethal cancer worldwide, often diagnosed at advanced stages, with limited treatment options and poor survival. Beyond established risk factors, the ABO blood group system has been suggested as a potential prognostic factor, but …

Association between ABO blood groups and gastric cancer outcomes: a Kaplan-Meier-derived patient data meta-analysis

Francisco Cézar Aquino de Moraes, Gustavo Tadeu Freitas Uchôa Matheus, Luis Henrique Rios Moreira Rego, Felipe Alves de Paiva et autres

Background Gastric cancer (GC) remains the fifth most common and lethal cancer worldwide, often diagnosed at advanced stages, with limited treatment options and poor survival. Beyond established risk factors, the ABO blood group system has been suggested as a potential prognostic factor, …

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iPSC-derived skeletal muscle spheroids for Duchenne Muscular Dystrophy modeling

Joyce Esposito, Felipe de Souza Leite, Igor Neves Barbosa, Thaís Maria da Mata Martins et autres

BACKGROUND: The progressive skeletal muscle degeneration observed in Duchenne Muscular Dystrophy (DMD) patients requires multiple cycles of satellite cells (SCs) activation to promote tissue regeneration. Dystrophic SCs present intrinsic defects, and the disrupting fibrotic niche hinders appropriate muscle recovery. Traditional 2D culture …

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Antiviral Potential of 3,4-Dimethoxychalcone Against SARS-CoV-2: A Promising Candidate

Washington Kleber Rodrigues Lima, Gláucio Monteiro Ferreira, Claudia Zeneida Gomes Parente Alves Lima, Eduardo Willian de Alencar Pereira et autres

INTRODUCTION: This study aimed to investigate the potential of LQPN-05, a compound derived from Fridericia platyphylla flowers, as a novel antiviral agent against SARS-CoV-2. METHODS: Molecular modeling and dynamics simulations were used to analyze the interaction between LQPN-05 and the SARS-CoV-2 spike …

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CD39 regulates P2RX7-mediated lung necrotic lesions in severe experimental tuberculosis

Gislane Almeida-Santos, Igor Santiago-Carvalho, Fabrício Moreira Almeida, Caio César Barbosa Bomfim et autres

Infection with Mycobacterium tuberculosis can cause diverse lesions, such as necrotic pneumonia, which can contribute to tuberculosis progression and transmission between individuals. Despite advances in understanding the role of ATP-gated P2RX7 ion channels in the development of severe forms of the disease, …

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