Fernando de Queiroz Cunha

Unravelling Ferroptosis in Sepsis: A Comprehensive Integrative Transcriptomic Analysis Across Age and Disease Severity

Miguel Victor Bringel Sales, Helder Imoto Nakaya, Fernando de Queiroz Cunha, Antônio Edson Rocha Oliveira

Ferroptosis, an iron-dependent, regulated form of cell death, has been increasingly recognised as a pivotal driver of organ dysfunction and mortality in sepsis. Despite its importance, the transcriptomic regulation of ferroptosis in human sepsis has not been systematically characterised. Here, we present …

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Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection

Paula Paccielli Freire, Dennyson Leandro M. Fonseca, Letícia Oliveira Lopes, Ivana Silva Ferreira et autres

Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SARS-CoV-2-induced myocardial injury. Histological examination of cardiac tissue …

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Nrf2 dynamically regulates RANKL-induced osteoclastogenesis and cathepsin K function

Cesar A. Speck‐Hernandez, Taíssa C. de Souza Furtado, Laisa Y. de Souza, Keteryne R. da Silva et autres

Osteoclasts mediate bone resorption primarily through the protease Cathepsin K. RANKL, the master cytokine driving osteoclastogenesis, elevates reactive oxygen species (ROS) levels that promote osteoclast differentiation; however, excessive ROS can lead to oxidative stress and cellular damage. To counteract the detrimental effects …

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CHECKPOINT IMMUNOTHERAPY ENHANCES PACLITAXEL-INDUCED NEUROPATHIC PAIN

Carlos Wagner de Souza Wanderley, Alexandre Manganin, Beatriz Adjafre, Elidianne Anibal et autres

All articles of this category (opens in new window) Introduction: The checkpoint immunotherapy with PD-1/PD-L1 inhibitors has achieved satisfactory clinical efficacy for the treatment of solid tumors. However, not all patients are sensitive to immune checkpoint blockade. In this context, the increasing …

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Participação do óxido nítrico no desenvolvimento da hiperalgesia da artrite por adjuvante em ratos

J M N Alves, Webster Glayser Pimenta dos Reis, M A K F Tatsuo, Fernando de Queiroz Cunha et autres