Polygenic prediction of body mass index and obesity through the life course and across ancestries
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359Institutions déclarées
37Pays d’affiliation déclarés
Résumé fourni par la source
Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South Asian ancestry) from the GIANT consortium and 23andMe, Inc., we developed ancestry-specific and multi-ancestry PGSs. The multi-ancestry score explained 17.6% of BMI variation among UK Biobank participants of European ancestry. For other populations, this ranged from 16% in East Asian-Americans to 2.2% in rural Ugandans. In the ALSPAC study, children with higher PGSs showed accelerated BMI gain from age 2.5 years to adolescence, with earlier adiposity rebound. Adding the PGS to predictors available at birth nearly doubled explained variance for BMI from age 5 onward (for example, from 11% to 21% at age 8). Up to age 5, adding the PGS to early-life BMI improved prediction of BMI at age 18 (for example, from 22% to 35% at age 5). Higher PGSs were associated with greater adult weight gain. In intensive lifestyle intervention trials, individuals with higher PGSs lost modestly more weight in the first year (0.55 kg per s.d.) but were more likely to regain it. Overall, these data show that PGSs have the potential to improve obesity prediction, particularly when implemented early in life.
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Contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Polygenic prediction of body mass index and obesity through the life course and across ancestries
- Date Crossref
- 21/07/2025
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.
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University of CopenhagenLeiden University Medical CenterNovo Nordisk FoundationIcahn School of Medicine at Mount SinaiUniversity of BristolMRC Epidemiology UnitEmory UniversityAtlanta VA Health Care SystemNational Cancer InstituteDivision of Cancer Epidemiology and GeneticsUniversity of MichiganNanjing Medical UniversityThe University of QueenslandUniversity College CopenhagenUniversity of North Carolina at Chapel HillGeisinger Health SystemVanderbilt University Medical CenterQueen Mary University of LondonWilliam Harvey Research InstituteBroad InstituteBrigham and Women's HospitalRIKEN Center for Integrative Medical SciencesThe University of OsakaUniversity of Massachusetts AmherstBoston Children's HospitalWake Forest UniversityUniversity of OxfordUniversity of ExeterCentre for Human GeneticsUniversity of TartuErasmus MCRTI InternationalSIB Swiss Institute of BioinformaticsUniversity of LausanneKyushu UniversityUniversity of California San DiegoUniversity of California, Los 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InstituteUniversity of UtahUniversity of South AustraliaSouth Australian Health and Medical Research InstituteJichi Medical UniversityAlbert Einstein College of MedicineBrunel University of LondonWenzhou Medical UniversityAffiliated Eye Hospital of Wenzhou Medical CollegeInstitut FrançaisL V Prasad Eye InstituteFondation de RothschildNetherlands Heart InstituteThe University of TokyoThe Catholic University of Korea Incheon St. Mary's HospitalChurchill HospitalOxford Centre for Diabetes, Endocrinology and MetabolismVerve Therapeutics (United States)Yonsei UniversityAnyang Eye HospitalAtrial Fibrillation NETworkUniversity of BirminghamHelsinki University HospitalMinerva FoundationLaiko General Hospital of AthensUniversity Hospital LeipzigUniversity of EssexInstitute for Social and Economic ResearchUniversity of Eastern FinlandKuopio University HospitalUniversity of Colorado DenverBerlin Institute of Health at Charité - Universitätsmedizin BerlinUniversity of Iowa Hospitals and 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UniversityKurume UniversityUniversity of PittsburghUPMC Hillman Cancer CenterTUM KlinikumUniversity of OsloImam Abdulrahman Bin Faisal UniversityUniversity of GenevaJames S. McDonnell FoundationUganda Virus Research InstituteUniversity of ConnecticutPediatrics and GeneticsChild Health and Development Institute
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