Shengchao A. Li

Different diabetes types and pancreatic ductal adenocarcinoma: a Mendelian randomization and pathway/gene-set analysis

Xing Hua, Chirayu Mohindroo, Xiaoyu Wang, Diptavo Dutta et autres

BACKGROUND: The associations between different types of diabetes, characterized by distinct pathophysiology and genetic architecture, and pancreatic ductal adenocarcinoma (PDAC) risk are not understood. METHODS: We investigated associations of genetic susceptibility to type 2 diabetes (T2D), 8 T2D mechanistic clusters, type 1 …

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Abstract B059: Blood proteomic profiles and pancreatic ductal adenocarcinoma risk – A Mendelian randomization and observational analysis

Ting Zhang, Devika Godbole, Ziqiao Wang, Xiaoyu Wang et autres

Abstract Background: Blood proteomic biomarkers hold promises for early detection and etiologic insights into pancreatic ductal adenocarcinoma (PDAC). We investigated the associations between genetically predicted plasma protein levels and PDAC risk using Mendelian randomization (MR) and confirmed MR identified PDAC-associated proteins in …

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Polygenic prediction of body mass index and obesity through the life course and across ancestries

Roelof A. J. Smit, Kaitlin H. Wade, Qin Hui, Joshua Arias et autres

Polygenic scores (PGSs) for body mass index (BMI) may guide early prevention and targeted treatment of obesity. Using genetic data from up to 5.1 million people (4.6% African ancestry, 14.4% American ancestry, 8.4% East Asian ancestry, 71.1% European ancestry and 1.5% South …

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Author Correction: Genetically adjusted PSA levels for prostate cancer screening

Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt et autres

In the version of this article initially published, the graph shown in Fig. 6b was an inadvertent duplicate of Fig. 6a, while the key label now reading “PSA G + PGS 269 ” originally read “PSA G + PRS 269 .” The …

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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves prediction across ancestry groups

Thomas J. Hoffmann, Rebecca E. Graff, Ravi Madduri, Alex A Rodriguez et autres

We conducted a multiancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry, 58,236 African ancestry, 23,546 Hispanic/Latino and 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant …

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Polygenic Risk Score and Lung Adenocarcinoma Risk Among Never-Smokers by EGFR Mutation Status: A Brief Report

Batel Blechter, Chao A. Hsiung, Xiaoyu Wang, Haoyu Zhang et autres

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Transcriptome-wide association analysis identifies candidate susceptibility genes for prostate-specific antigen levels in men without prostate cancer

Dorothy M. Chen, Ruocheng Dong, Linda Kachuri, Thomas J. Hoffmann et autres

) genes. Out of 173 unique PSA-associated genes across analyses, we replicated 151 (87.3%) in a TWAS of 209,318 PCa-free individuals from the Million Veteran Program. Based on conditional analyses, we found 20 genes (11 single tissue, nine cross-tissue) that were associated …

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Genome-wide association study of prostate-specific antigen levels in 392,522 men identifies new loci and improves cross-ancestry prediction

Thomas J. Hoffmann, Rebecca E. Graff, Ravi Madduri, Alex A Rodriguez et autres

We conducted a multi-ancestry genome-wide association study of prostate-specific antigen (PSA) levels in 296,754 men (211,342 European ancestry; 58,236 African ancestry; 23,546 Hispanic/Latino; 3,630 Asian ancestry; 96.5% of participants were from the Million Veteran Program). We identified 318 independent genome-wide significant (p≤5e-8) …

us, Nigéria, Ghana, Afrique du Sud, Sénégal, se (code pays fourni par la source)

Genetically adjusted PSA levels for prostate cancer screening

Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt et autres

Abstract Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer-related PSA variation has potential to improve screening utility. In this study, we discovered 128 genome-wide …

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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

Jianxin Shi, Kouya Shiraishi, Jiyeon Choi, Keitaro Matsuo et autres

Abstract Lung adenocarcinoma is the most common type of lung cancer. Known risk variants explain only a small fraction of lung adenocarcinoma heritability. Here, we conducted a two-stage genome-wide association study of lung adenocarcinoma of East Asian ancestry (21,658 cases and 150,676 …

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Transcriptome-Wide Association Analysis Identifies Novel Candidate Susceptibility Genes for Prostate-Specific Antigen Levels in Men Without Prostate Cancer

D. Chen, Ruocheng Dong, Linda Kachuri, Thomas J. Hoffmann et autres

Abstract Deciphering the genetic basis of prostate-specific antigen (PSA) levels may improve their utility to screen for prostate cancer (PCa). We thus conducted a transcriptome-wide association study (TWAS) of PSA levels using genome-wide summary statistics from 95,768 PCa-free men, the MetaXcan framework, …

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Genetically adjusted PSA levels for prostate cancer screening

Linda Kachuri, Thomas J. Hoffmann, Yu Jiang, Sonja I. Berndt et autres

Prostate-specific antigen (PSA) screening for prostate cancer remains controversial because it increases overdiagnosis and overtreatment of clinically insignificant tumors. Accounting for genetic determinants of constitutive, non-cancer PSA variation has potential to improve screening utility. We discovered 128 genome-wide significant associations (P<5×10-8) in …

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