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Accès ouvert déclaré 2024 article

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

102Citations signalées — pas une note de qualité
293Institutions déclarées
5Pays d’affiliation déclarés

Résumé fourni par la source

. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. IL-1R2, MATN2 and COLEC12 were associated with cardiorespiratory symptoms, fatigue and anxiety/depression; MATN2, CSF3 and C1QA were elevated in gastrointestinal symptoms and C1QA was elevated in cognitive impairment. Additional markers of alterations in nerve tissue repair (SPON-1 and NFASC) were elevated in those with cognitive impairment and SCG3, suggestive of brain-gut axis disturbance, was elevated in gastrointestinal symptoms. Severe acute respiratory syndrome coronavirus 2-specific immunoglobulin G (IgG) was persistently elevated in some individuals with long COVID, but virus was not detected in sputum. Analysis of inflammatory markers in nasal fluids showed no association with symptoms. Our study aimed to understand inflammatory processes that underlie long COVID and was not designed for biomarker discovery. Our findings suggest that specific inflammatory pathways related to tissue damage are implicated in subtypes of long COVID, which might be targeted in future therapeutic trials.

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Date Crossref
01/04/2024
Éditeur
Springer Science and Business Media LLC
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

Imperial College LondonUniversity of LeicesterNIHR Leicester Biomedical Research CentreUniversity of LiverpoolImperial College Healthcare NHS TrustHealth Protection Research Unit in Emerging and Zoonotic Infections at University of LiverpoolNHS LothianEdinburgh Royal InfirmaryUniversity of EdinburghUniversity of SheffieldUniversity of DundeeNinewells HospitalUniversity of OxfordMRC Human Immunology UnitUniversity of ManchesterAsthma UKMRC University of Glasgow Centre for Virus ResearchCentre for Inflammation ResearchThe Queen's Medical Research InstituteRoyal London HospitalLondon School of Hygiene & Tropical MedicineHospital for Tropical DiseasesUniversity College LondonNorth Bristol NHS TrustUniversity of BristolKing's College LondonKing's College Hospital NHS Foundation TrustRoslin InstituteGuy's and St Thomas' NHS Foundation TrustRoyal Free London NHS Foundation TrustUniversity Hospitals Birmingham NHS Foundation TrustUniversity of BirminghamStroke AssociationUniversity College HospitalLung InstituteOxford University Hospitals NHS TrustSt George’s University Hospitals NHS Foundation TrustUniversity Hospitals of Leicester NHS TrustUniversity of ExeterAintree University Hospitals NHS Foundation TrustSherwood Forest Hospitals NHS Foundation TrustNottingham University Hospitals NHS TrustUniversity of NottinghamManchester University NHS Foundation TrustHampshire Hospitals NHS Foundation TrustBritish Heart FoundationNHS Greater Glasgow and ClydeUniversity of GlasgowQueen's University BelfastBelfast Health and Social Care TrustAiredale NHS Foundation TrustWrightington, Wigan and Leigh NHS Foundation TrustUniversity of LeedsLeeds Teaching Hospitals NHS TrustUniversity of HullEast Kent Hospitals University NHS Foundation TrustNewcastle upon Tyne Hospitals NHS Foundation TrustEast Cheshire NHS TrustRoyal Albert Edward InfirmarySheffield Teaching Hospitals NHS Foundation TrustWirral University Teaching Hospital NHS Foundation TrustWestern General HospitalInstitute of Genetics and CancerSwansea UniversityUniversity of SouthamptonNHS HighlandPapworth Hospital NHS Foundation TrustUniversity Hospitals of Derby and Burton NHS Foundation TrustNHS LanarkshireUniversity of CambridgeCambridge University Hospitals NHS Foundation TrustRoyal Liverpool University HospitalLoughborough UniversityBetsi Cadwaladr University Health BoardGolden Jubilee National HospitalBradford Teaching Hospitals NHS Foundation TrustSouth London and Maudsley NHS Foundation TrustCardiff and Vale University Health BoardYeovil District Hospital NHS Foundation TrustWhittington Health NHS TrustHarrogate and District NHS Foundation TrustNewcastle UniversityTameside and Glossop Integrated Care NHS Foundation TrustUnited Lincolnshire Hospitals NHS TrustUniversity Hospital Southampton NHS Foundation TrustKing's College HospitalBarts Health NHS TrustLewisham and Greenwich NHS TrustHywel Dda University Health BoardNHS TaysideSt Thomas' HospitalSt. Thomas HospitalSwansea Bay University Health BoardKing's College SchoolMonash UniversityThe Rotherham NHS Foundation TrustSalford Royal NHS Foundation TrustCwm Taf University Health BoardBorders General HospitalSalford Royal HospitalAneurin Bevan University Health BoardUniversity Hospital of North DurhamLondon North West Healthcare NHS TrustAlzheimer’s Research UKHealth and Care Research WalesGreat Western HospitalKettering General Hospital NHS TrustRoyal Surrey NHS Foundation TrustChesterfield Royal Hospital NHS Foundation TrustWarwick HospitalNIHR Research Delivery NetworkBritish Lung FoundationNorth Middlesex University Hospital NHS TrustCentre for Mental HealthCardiff UniversityMcPin FoundationHillingdon Hospitals NHS Foundation TrustQueen Mary University of LondonMedawar Building for Pathogen ResearchPublic Health ScotlandOxford Research GroupSalisbury NHS Foundation TrustGateshead Health NHS Foundation TrustKidney Research UKNHS Dumfries and GallowayMental Health Research UKNorthern General HospitalShropshire Community Health NHS TrustTaunton & Somerset NHS Foundation TrustSomerset NHS Foundation TrustThe Royal Free HospitalHarefield HospitalThe Francis Crick InstituteClatterbridge Cancer Centre NHS Foundation TrustDiabetes UKBarnsley Hospital NHS Foundation TrustUniversity Hospital of North TeesBroomfield HospitalNorthumbria UniversityWelsh Centre for Printing and CoatingQueen Alexandra HospitalPrincess Royal HospitalBassetlaw HospitalDarent Valley HospitalQueen Elizabeth the Queen Mother HospitalAcademic Health Science Network North East and North CumbriaJohn Radcliffe HospitalManchester Royal InfirmaryFurness General HospitalHillingdon HospitalWarwickshire HospitalCoventry (United Kingdom)St Michael's HospitalStepping Hill HospitalBristol Royal Hospital for ChildrenScarborough General HospitalLiverpool Heart and Chest HospitalJames Paget University HospitalAberdeen Royal InfirmaryRoyal Devon and Exeter HospitalWorcestershire Royal HospitalConquest HospitalJames Cook University HospitalDorset County HospitalPublic Health EnglandRoyal Bournemouth HospitalHarrogate District HospitalRoyal Blackburn Teaching HospitalTorbay HospitalSt George's HospitalBlackpool Victoria HospitalNorfolk and Norwich University HospitalSalisbury District HospitalRoyal Oldham HospitalCounty HospitalSouthampton General HospitalNorthampton General HospitalUniversity Hospital of WalesUniversity Hospitals Bristol NHS Foundation TrustLiverpool School of Tropical MedicineLeighton HospitalWalsall Manor HospitalScunthorpe General HospitalWest Suffolk NHS Foundation TrustBasingstoke and North Hampshire HospitalCumberland InfirmaryMcGill University and Génome Québec Innovation CentreEuropean Genomic Institute for DiabetesBirmingham Children's HospitalNottingham City HospitalGlangwili General HospitalAlder Hey Children's HospitalBronglais General HospitalWorthing HospitalUniversity Hospitals Sussex NHS Foundation TrustHomerton University HospitalAiredale General HospitalBasildon HospitalThe Christie NHS Foundation TrustUniversity Hospital LewishamWhittington HospitalSouthmead HospitalSheffield Children's HospitalRoyal United HospitalSouthend University Hospital NHS Foundation TrustHinchingbrooke HospitalRoyal Preston HospitalUniversity Hospital CoventryWalton CentreManchester Academic Health Science CentreHull Royal InfirmaryDarlington Memorial HospitalQueen Elizabeth HospitalWarrington HospitalIsle of Wight NHS TrustSt Mary's HospitalSt. Mary's HospitalTunbridge Wells HospitalUniversity of UlsterRoyal Victoria HospitalCountess of Chester HospitalFrimley Park HospitalSt James's University HospitalArrowe Park HospitalGreat Ormond Street HospitalRoyal Shrewsbury HospitalAddenbrooke's HospitalEast Surrey HospitalBurton Hospitals NHS Foundation TrustPeterborough City HospitalKent and Canterbury HospitalWeston Area Health NHS TrustGlasgow Royal InfirmaryMacclesfield District General HospitalDerbyshire County CouncilChelsea and Westminster HospitalWatford General HospitalPrince Philip HospitalGeorge Eliot HospitalKettering General HospitalUniversity Hospitals of North Midlands NHS TrustRussells Hall HospitalLister HospitalMusgrove Park HospitalKingston HospitalQueen's HospitalSouthport and Formby District General HospitalSt George's, University of LondonPoole HospitalWilliam Harvey HospitalKings Mill HospitalLiverpool Women's HospitalPinderfields HospitalNorth Devon District HospitalQueen Elizabeth Hospital BirminghamTameside HospitalBirmingham City HospitalSt Mary's HospitalRoyal Manchester Children's HospitalNew Cross HospitalBedford HospitalColchester HospitalChesterfield Royal HospitalPrincess Alexandra HospitalMilton Keynes HospitalCentre for Human GeneticsRoyal Bolton HospitalRoyal Gwent HospitalRoyal Marsden HospitalNational Health ServiceQueen Victoria HospitalRoyal Stoke University HospitalWhiston HospitalCroydon University HospitalGloucestershire Royal HospitalWest Hertfordshire Hospitals NHS TrustNorth Middlesex HospitalMedway Maritime HospitalPapworth HospitalDerriford HospitalSt Helier HospitalRoyal Berkshire HospitalBradford Royal InfirmaryCentral Middlesex HospitalRoyal Cornwall HospitalSt Peter's HospitalLeicester Royal InfirmaryGrantham and District HospitalAintree University HospitalNorth Tyneside General HospitalQueen Elizabeth Hospital King's Lynn NHS Foundation TrustSt Peter's HospitalBMI The Runnymede Hospital

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Sujets associés

Long-Term Effects of COVID-19Neuroinflammation and Neurodegeneration MechanismsCOVID-19 Clinical Research Studies

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