James Moon

Vutrisiran Treatment and Changes in Cardiac Parameters and Amyloid Burden Assessed by Cardiovascular MRI

Yousuf Razvi, Awais Sheikh, Rishi K. Patel, Anouk Achten et autres

Importance: Transthyretin amyloid cardiomyopathy (ATTR-CM) is caused by extracellular myocardial ATTR amyloid infiltration. Vutrisiran, an RNA interference therapeutic that suppresses hepatic TTR production, met its primary end point in the HELIOS-B (A Study to Evaluate Vutrisiran in Patients With Transthyretin Amyloidosis With …

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Prevalence and determinants of asymmetric septal hypertrophy (ASH) in diseases of left ventricular hypertrophy (LVH)

Hunain Shiwani, Joao Augusto, Constantin‐Cristian Topriceanu, Adam Ioannou et autres

AIMS: To determine the prevalence of asymmetric septal hypertrophy(ASH) across health and in diseases associated with left ventricular hypertrophy(LVH), including hypertrophic cardiomyopathy(HCM). METHODS AND RESULTS: We analysed two complementary datasets. First, a large UK Biobank healthy reference cohort(n = 4,020) was used …

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Allergen-specific regulatory T cells form lung resident memory capable of suppressing Th2 recall responses to allergen 2267598

Ryan W. Nelson, Mateus Eustáquio Lopes, Lucas Faustino, Thao K. T. Nguyen et autres

Abstract Introduction Intranasal house dust mite (HDM) exposure elicits allergen-peptide (p):MHCII-specific Th2 and Tregs in the airways of mice. The balance between opposing pro- and anti-inflammatory functions of these cell populations may influence the outcome of airway re-exposure to HDM. However, the …

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Total respiratory tract immunization induces optimal systemic and regional antigen-specific immune responses 2244163

Juliana Barreto de Albuquerque, Neal Smith, YeePui Yeung, Isabela Kernin et autres

Abstract Introduction Respiratory infections represent a major global health challenge. Different intranasal vaccine strategies can target specific areas of the respiratory tract, which may influence local and systemic immune responses. Methods Here, we combined peptide-major histocompatibility complex class I and II (pMHCI …

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Establishment of tissue-resident self-antigen-specific regulatory T cells protects the lung against recurrent injury 2255936

Daniel Shin, James Moon

Abstract Introduction Self-reactive T cells present a threat to normal healthy tissue and are heavily regulated at steady-state by various mechanisms of peripheral tolerance. We previously reported a near-unilateral expansion of CD4+ Foxp3+ regulatory T cells (Tregs) among self-antigen-specific T cell populations …

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A unique subset of allergen specific T helper 2 + 17 tissue resident memory cells is established in a mouse model of allergic inflammation 2257678

Alice Emma Taliento, Wei Wang, Yan Bai, Caiqi Zhao et autres

Abstract Introduction Asthma is one of the most common chronic respiratory diseases. Anamnestic inflammation in asthma is sustained by allergen-specific tissue-resident memory (TRM) CD4+ T cells. In addition to the Th2 pathway, components of the Th17 response have been identified as contributors …

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Realistic anatomical model reconstruction and high-fidelity flow computation in stented coronary arteries for the analysis of in-stent thrombosis

Ryo Torii, Amear Mohammed, Mazen Abou Gamrah, Ibrahim Halil Tanboga et autres

Background and aims This article aims to develop and validate a methodology for realistic anatomical reconstruction of stented segments from optical coherence tomography (OCT) and angiographic images and the computation of local haemodynamic forces using computational fluid dynamics, towards a more realistic …

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88 Underserved communities at risk of heart failure: effectiveness of community-based recruitment strategies and burden of unrecognised cardiovascular disease

Nicholas Black, Fardad Soltani, Lucy Priestner, Joshua Bradley et autres

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Fatty acids in the tumor microenvironment reprogram neutrophils to induce immunosuppression via adenosine

Rashi Singhal, Nina W. Zhang, Zheng Hong Lee, Hannah Noelle Bell et autres

As solid tumors progress, the tumor microenvironment (TME) becomes increasingly immunosuppressive, impairing cytotoxic T-cell activity and limiting the efficacy of the immune checkpoint blockade. However, the mechanistic drivers of this immunosuppression remain poorly understood. Here, we identify a tumor-derived lipid-neutrophil-adenosine axis as …

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Phase II Selection Designs

James Moon, Michael Leo LeBlanc, Michael C. Wu, P. Y. Liu et autres

When there are multiple promising new therapies in a disease setting, it may not be feasible to test them all against the standard treatment in a definitive phase III trial. The sample sizes required for a phase III study with more than …

456eP CD69high TIM3+ cytotoxic T cells inhibit the metastasis of gastric cancer through MAPK signaling pathway

Y.J. Jung, James Moon, J.Y. Jhun, J. K. Hwang et autres

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Precision, prognosis, and clinical performance of rounded and trabecular segmentation of cine cardiovascular magnetic resonance

George Joy, James Moon, Karan Punjabi, Mohammed Alzahir et autres

BACKGROUND: Measurements of cardiac size and function drive clinical decisions. Left ventricular (LV) metrics can be derived from cardiac MR images by delineating the blood pool and myocardium, by either drawing a rounded contour to approximate the compacted myocardial border, or by …

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