Edward Thomas Bullmore

Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia

Eugenia Radulescu, Petra E. Vértes, Shizhong Han, Jennifer A. Erwin et autres

=349; sex: M/F = 242/107). Here we identify differentially connected genes (DCG) in schizophrenia networks that deviate from architectural relationships characteristic of neurotypical gene networks based on three network metrics- total connectivity (kTot), clustering coefficient (C), and intra-module degree (kIn). We find …

us, gb, py (code pays fourni par la source)

Analysis of gene co-expression connectivity dynamics implicates aberrant neuron-oligodendroglia interactions in schizophrenia.

Eugenia Radulescu, Petra E. Vértes, Shizhong Han, Jennifer A. Erwin et autres

The genetic architecture of cortical similarity networks

Isaac Sebenius, Varun Warrier, Richard A. I. Bethlehem, Richard Dear et autres

Abstract The genetic architecture of human brain networks is central to understanding cortical organisation and evolution, the causal links between brain structure and function, and the pathogenesis of neuropsychiatric disorders. Using N > 48,000 subjects, we investigated common genetic effects on Morphometric …

us, gb, es (code pays fourni par la source)

Peripheral inflammation is associated with reduced influx of TSPO PET tracers into the brain: insights from a non-invasive mapping methodology

Leonardo Barzon, Lucia Maccioni, Manuela Moretto, Alessio Giacomel et autres

Abstract Introduction Neuroinflammation is a hallmark of various brain disorders, including neuropsychiatric conditions like major depressive disorder and schizophrenia. Increasing evidence suggests that both peripheral and central inflammation play a critical role in central nervous system dysfunction associated with such disorders. There …

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Network-based disease fingerprinting with neuroinflammation PET imaging

Leonardo Barzon, Lucia Maccioni, Michelle Carranza Mellana, Julia J. Schubert et autres

Neuroinflammation is a hallmark of numerous neurodegenerative, psychiatric, and chronic pain disorders and can be assessed in vivo with 18 kDa translocator protein (TSPO) positron emission tomography (PET). However, conventional quantification methods of TSPO PET are limited and often overlook the spatial …

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Additional file 1 of Network-based disease fingerprinting with neuroinflammation PET imaging

Leonardo Barzon, Lucia Maccioni, Michelle Carranza Mellana, Julia J. Schubert et autres

Supplementary Material 1.

it, fr, gb, us, jp, se, ca (code pays fourni par la source)

Additional file 1 of Network-based disease fingerprinting with neuroinflammation PET imaging

Leonardo Barzon, Lucia Maccioni, Michelle Carranza Mellana, Julia J. Schubert et autres

Supplementary Material 1.

it, fr, gb, us, jp, se, ca (code pays fourni par la source)

NMDAR subunit GluN1 dynamics in urinary astrocyte-derived extracellular vesicles in anti-NMDAR encephalitis

Junhua Mei, Mian-mian Chen, Qing Yang, Shu‐xian Xu et autres

Abstract Background and Objectives Longitudinal measurement in vivo of molecular changes in the central nervous system (CNS) is important to investigate and guide treatment of rapidly changing neurological diseases. Here, we show how a novel protocol for urinary astrocyte-derived extracellular vesicles (uADEVs) …

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Plasma proteomics reveal heterogeneous subtypes of depression linked to inflammation and aging

Zhengxu Lian, Lena Palaniyappan, Yuanli Guo, Zhaowen Liu et autres

Abstract The clinical heterogeneity of depression has defied biological classification, limiting personalized treatment. Previous neuroimaging- or symptom-based subtyping of depression failed to clarify the underlying pathoetiology, while plasma proteins which integrates signals from multiple organ systems, offers a promising way to define …

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Global & Community Health: What Did the COVID-19 Pandemic Teach Us About Neurologic Surveillance Approaches, and How Should We Be Better Prepared?

Rachael Matthews, Mark Alexander Ellul, Stephen McKeever, Catherine F. Houlihan et autres

It is well recognized that many pandemic viruses are associated with neurologic complications, most recently with COVID-19. After the outbreak of the COVID-19 pandemic, neurologic surveillance platforms were implemented to characterize the complications of COVID-19. Surveillance platforms are invaluable in providing timely …

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Right time, right place: Heterochronicity shapes brain network formation

Francesco Poli, Stuart Oldham, Edward Thomas Bullmore, Petra E. Vértes et autres

Abstract Brain network formation unfolds on a non-uniform developmental timetable, with different cortical regions generating connections at different developmental phases. Generative network models (GNMs) aim to uncover the principles underpinning the organisation of connectomes by creating synthetic networks according to simple computational …

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M15. GWAS OF MACRO-SCALE RESTING STATE FUNCTIONAL BRAIN NETWORKS IDENTIFY SHARED BIOLOGY WITH BRAIN STRUCTURE AND AUTISM

Yuankai He, Rafael Romero-García, Bin Wan, Jakob Grove et autres

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