Sarah D. Tait

Author Correction: Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict Daniel Michael, Cordelia Dunai, Edward Needham, Kukatharmini Tharmaratnam et autres

The original version of this article omitted three members of the COVID-CNS Consortium. Alex Berry and Obioma Orazulume, who are from the ‘University College London, London, UK’, and Ian Galea, who is from the ‘University of Southampton, Southampton, UK’ were added to …

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Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease

Felicity Liew, Claudia Efstathiou, Sara Fontanella, Matthew W. Richardson et autres

. Here we profiled 368 plasma proteins in 657 participants ≥3 months following hospitalization. Of these, 426 had at least one long COVID symptom and 233 had fully recovered. Elevated markers of myeloid inflammation and complement activation were associated with long COVID. …

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Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses

Benedict Daniel Michael, Cordelia Dunai, Edward Needham, Kukatharmini Tharmaratnam et autres

To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1-11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). …

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Delayed Mucosal Antiviral Responses Despite Robust Peripheral Inflammation in Fatal COVID-19

Jasmin K. Sidhu, Matthew K. Siggins, Felicity Liew, Ashley Sanchez Sevilla Uruchurtu et autres

BACKGROUND: While inflammatory and immune responses to SARS-CoV-2 infection in peripheral blood are extensively described, responses at the upper respiratory mucosal site of initial infection are relatively poorly defined. We sought to identify mucosal cytokine/chemokine signatures that distinguished COVID-19 severity categories, and …

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Correction: Implementation of an educational intervention to improve medical student cost awareness: a prospective cohort study

Sarah D. Tait, Sachiko M. Oshima, Harold J. Leraas, Alexander H. Gunn et autres

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CHARACTERIZING PATTERNS OF ANTIFIBROTIC USE IN PATIENTS WITH INTERSTITIAL LUNG DISEASE AND NON-SMALL CELL LUNG CANCER: A RETROSPECTIVE COHORT STUDY

Sarah D. Tait, HATEM ELLAITHY, Ibiayi Dagogo‐Jack, Angela J. Frank et autres

Quantifying neutralising antibody responses against SARS-CoV-2 in dried blood spots (DBS) and paired sera

Kelly J. Roper, Jordan Thomas, Wejdan Oudah Albalawi, Emily Maddocks et autres

The ongoing SARS-CoV-2 pandemic was initially managed by non-pharmaceutical interventions such as diagnostic testing, isolation of positive cases, physical distancing and lockdowns. The advent of vaccines has provided crucial protection against SARS-CoV-2. Neutralising antibody (nAb) responses are a key correlate of protection, …

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International Pediatric COVID-19 Severity Over the Course of the Pandemic

Yanshan Zhu, Flávia Jacqueline Almeida, John Kenneth Baillie, Asha C Bowen et autres

Importance: Multiple SARS-CoV-2 variants have emerged over the COVID-19 pandemic. The implications for COVID-19 severity in children worldwide are unclear. Objective: To determine whether the dominant circulating SARS-CoV-2 variants of concern (VOCs) were associated with differences in COVID-19 severity among hospitalized children. …

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Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that …

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Genomic investigations of unexplained acute hepatitis in children

Sofia Morfopoulou, Sarah Buddle, Oscar Enrique Torres Montaguth, Laura Atkinson et autres

. Here we report an investigation of 38 cases, 66 age-matched immunocompetent controls and 21 immunocompromised comparator participants, using a combination of genomic, transcriptomic, proteomic and immunohistochemical methods. We detected high levels of adeno-associated virus 2 (AAV2) DNA in the liver, blood, …

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Adeno-associated virus 2 infection in children with non-A–E hepatitis

Antonia Ying Wai Ho, Richard J Orton, Rachel Tayler, Patawee Asamaphan et autres

An outbreak of acute hepatitis of unknown aetiology in children was reported in Scotland1 in April 2022 and has now been identified in 35 countries2. Several recent studies have suggested an association with human adenovirus with this outbreak, a virus not commonly …

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