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Accès ouvert déclaré 2024 article

Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

11Citations signalées — pas une note de qualité
59Institutions déclarées
5Pays d’affiliation déclarés

Résumé fourni par la source

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome.

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Contrôle bibliographique ouvert

DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.

Titre Crossref
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Date Crossref
31/01/2024
Éditeur
Springer Science and Business Media LLC
Type
journal-article

Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude et ne compte pas comme une seconde source scientifique indépendante.

Institutions déclarées

University of EdinburghUniversity College LondonUniversity of Wisconsin–MadisonUniversity of TorontoLiverpool School of Tropical MedicineUniversity of LancashireUniversity of ExeterUniversity of OxfordManchester University NHS Foundation TrustUniversity Hospitals Bristol NHS Foundation TrustUniversity Hospitals Bristol and Weston NHS Foundation TrustNational Institute for Health and Care ResearchUniversity of LiverpoolAintree University Hospitals NHS Foundation TrustOxford University Hospitals NHS TrustSheffield Teaching Hospitals NHS Foundation TrustNewcastle upon Tyne Hospitals NHS Foundation TrustUniversity Hospital Southampton NHS Foundation TrustNIHR Southampton Biomedical Research CentreUniversity of SouthamptonUniversity Hospitals Birmingham NHS Foundation TrustNorth Tees and Hartlepool NHS Foundation TrustMid Cheshire Hospitals NHS Foundation TrustNorthumbria Healthcare NHS Foundation TrustRoyal Devon & Exeter NHS Foundation TrustNHS LothianEdinburgh Royal InfirmaryNHS DigitalIntensive Care National Audit & Research CentreNational Records of ScotlandPublic Health ScotlandSwansea UniversityMilton Keynes Hospital NHS Foundation TrustBuckinghamshire Healthcare NHS TrustMedway NHS Foundation TrustNottingham University Hospitals NHS TrustBolton NHS Foundation TrustPennine Acute Hospitals NHS TrustRoyal Surrey County HospitalWestern General HospitalNHS FifeVictoria HospitalShrewsbury and Telford Hospital NHS TrustRoyal Free London NHS Foundation TrustRoyal Berkshire NHS Foundation TrustWarrington and Halton Teaching Hospitals NHS Foundation TrustEast Kent Hospitals University NHS Foundation TrustRoslin InstituteImperial College Healthcare NHS TrustUniversity of St AndrewsUniversity of ManchesterNIHR Oxford Musculoskeletal Biomedical Research CentreOxford University Clinical Research UnitUniversity of CambridgeMRC Biostatistics UnitUniversity of RegensburgUniversity of NottinghamUniversity of BristolOxford BioMedica (United Kingdom)

Une affiliation ne permet pas de déduire la nationalité d’un auteur.

Sujets associés

Long-Term Effects of COVID-19COVID-19 Clinical Research StudiesThermal Regulation in Medicine

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