Kathryn Curtis

Canadian Consensus Guidelines for the Diagnosis and Management of Spontaneous Intracranial Hypotension

Farnaz Amoozegar, Bahareh N. Cloutier, Nathan Brown, Andrew Callen et autres

Spontaneous intracranial hypotension (SIH) is a disabling neurological condition that is often treatable, and in many cases curable.Despite this, SIH is often mis-or underdiagnosed, and significant gaps in care exist in Canada.Patients often face long delays in obtaining diagnosis and treatment, and …

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Treating pain and trauma: A systematic review of non-randomized studies of psychotherapeutic approaches

Rachael Bosma, Kathryn Curtis, Callon Williams, P. Maxwell Slepian et autres

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Is treating both chronic pain and trauma-related symptoms at the same time effective? A systematic review and meta-analysis of psychological interventions

Brittany N. Rosenbloom, Kathryn Curtis, Callon M. Williams, P. Maxwell Slepian et autres

ABSTRACT: There is a large proportion of people living with chronic pain who also experience posttraumatic stress symptoms; however, there is no current standard treatment for addressing these mutually maintaining conditions. The aim of this systematic review and meta-analysis was to examine …

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Evaluation of a mental health screening tool to determine the need for psychological interview for patients offered neuromodulation implant therapies for pain

Maggie Z. X. Xiao, Kathryn Curtis, Abigail Muere, Hemkumar Pushparaj et autres

INTRODUCTION: Psychological comorbidities can negatively impact outcomes of spinal cord stimulation (SCS) for chronic pain. While psychological assessment is commonly required before SCS implantation, evidence supporting its impact on outcomes is limited, and such assessments may be unnecessary for many patients and …

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Evaluation of the Transitional Pain Service Specialized Iyengar-Informed Yoga Program for Chronic Post-Surgical Pain: A Pilot Randomized Controlled Trial

Kathryn Curtis, Hance A. Clarke, Daniel Santa Mina, Gitte Bechsgaard et autres

The objective of this randomized controlled trial (RCT) was to evaluate the feasibility and efficacy of a specialized Iyengar-informed yoga intervention for individuals who experience chronic post-surgical pain (CPSP). This prospective, multi-wave pilot RCT was pre-registered at clinicaltrials.gov (NCT03460028) and designed in …

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Sotrovimab versus usual care in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Kaja Abbas et autres

BACKGROUND: Sotrovimab is a neutralising monoclonal antibody targeting the SARS-CoV-2 spike protein. We aimed to evaluate the efficacy and safety of sotrovimab in the RECOVERY trial, an investigator-initiated, individually randomised, controlled, open-label, adaptive platform trial testing treatments for patients admitted to hospital …

Higher dose corticosteroids in hospitalised COVID-19 patients requiring ventilatory support (RECOVERY): a randomised, controlled, open-label, platform trial

Obbina Abani, Amr E. Abbas, Fatima H. Abbas, Jaffar Abbas et autres

Background: Low dose corticosteroids (e.g., 6 mg dexamethasone) have been shown to reduce mortality for hypoxic COVID-19 patients. We have previously reported that higher dose corticosteroids cause harm in patients with clinical hypoxia but not receiving ventilatory support (the combination of non-invasive …

Ten years of transitional pain service research and practice: where are we and where do we go from here?

Hance A. Clarke, Anna S. Waisman, Andrea Aternali, Kristina Axenova et autres

Chronic postsurgical pain (CPSP) is a prevalent yet unintended consequence of surgery with substantial burdens to the individual and their family, the healthcare system, and society at large. The present article briefly reviews the evidence for transitional pain services (TPSs) that have …

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Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Peter AG Sandercock, Janet H Darbyshire, David L. DeMets, Robert Fowler et autres

Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In …

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A Randomized Controlled Trial of Clinical Hypnosis as an Opioid-Sparing Adjunct Treatment for Pain Relief in Adults Undergoing Major Oncologic Surgery

Brittany N. Rosenbloom, P. Maxwell Slepian, Muhammed Abid Azam, Andrea Aternali et autres

Abstract: Clinical hypnosis is an effective strategy for managing acute pain in the surgical setting. However, the opioid sparing effects of clinical hypnosis are not as well understood. This pre-registered (NCT03730350) randomized, controlled trial (RCT) examined the impact of clinical hypnosis, pre- …

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510 Anxiety and depression screening in adolescents with cystic fibrosis before and after elexacaftor-tezacaftor-ivacaftor initiation: a retrospective review

E. Muther, E. Lyons, Kathryn Curtis

Presentation, care, and outcomes of patients with NSTEMI according to World Bank country income classification: the ACVC-EAPCI EORP NSTEMI Registry of the European Society of Cardiology

Ramesh Nadarajah, Peter Ludman, Cécile Laroche, Salvatore Brugaletta et autres

BACKGROUND: The majority of NSTEMI burden resides outside high-income countries (HICs). We describe presentation, care, and outcomes of NSTEMI by country income classification. METHODS AND RESULTS: Prospective cohort study including 2947 patients with NSTEMI from 287 centres in 59 countries, stratified by …

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