Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris E. Jansen, Eric Yu, Aude Nicolas, Thiago Peixoto Leal, Akinori Miyashita, Céline Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier‐Boley, Tatsuhiko Naito, Fahri Küçükali, Seth D. Talyansky, Selina Yogeshwar, Vicente Peris Sempere, Wataru Satake, Victoria Álvarez, Beatrice Arosio, Michaël E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, María J. Bullido, Paolo Caffarra, Jordi Clarimón, Antonio Daniele, D.H. Darling, Stéphanie Debette, Jean‐François Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Düzel, Daniela Galimberti, Guillermo García‐Ribas, José María García‐Alberca, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grünblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann‐Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Jürgen Deckert, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonça, Merçé Boada, Pablo Mir, Susanne Moebus, Fermín Moreno, Benedetta Nacmias, Gaël Nicolas, Shumpei Niida, Børge G. Nordestgaard, Goran Papenberg, Janne M. Papma, Lucilla Parnetti, Florence Pasquier, Pau Pástor, Oliver Peters, Yolande A.L. Pijnenburg, Gerard Piñol‐Ripoll, Julius Popp, Laura Molina‐Porcel, Raquel Puerta, Jordi Pérez‐Tur, Innocenzo Rainero, Inez H.G.B. Ramakers, Luís Miguel Real, Steffi G. Riedel‐Heller, Eloy Rodríguez‐Rodríguez, Owen A. Ross, José Luís Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John C. van Swieten, Raquel Sánchez‐Valle, Eng‐King Tan, Thomas Tegos, Charlotte E. Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnálek, Frans Verhey, Margda Wærn, Jens Wiltfang, Jing Zhang, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Cornelia van Duin, Magda Tsolaki, Pascual Sánchez‐Juan, Ruth Frikke‐Schmidt, Kristel Sleegers, Tatsushi Toda, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Jia Nee Foo, Wiesje M. van der Flier, Takeshi Ikeuchi, Alfredo Ramı́rez, Ignácio F. Mata, Agustı́n Ruiz, Ziv Gan‐Or, Jean‐Charles Lambert, Michael D. Greicius, Emmanuel Mignot, Víctor Andrade, Sonia Moreno–Grau, Najaf Amin, Rafael Campos-Martín, Peter Holmans, Luca Kleineidam, Sven J. van der Lee, Amber Yaqub, Marcos R. Costa, Julien Chapuis, Shahzad Ahmad, Pablo García‐González, Carla Abdelnour, Emilio Alarcón‐Martín, Daniel Alcolea, Montserrat Alegret, Ignacio Álvarez, Nicola J. Armstrong, Tsolaki Anthoula, Ildebrando Appollonio, Marina Arcaro, Silvana Archetti, Alfonso Arias Pastor, Henri Bailly, Nerisa Banaj, Miquel Baquero, Ana Belén Pastor, Claudine Berr, Céline Besse, Valentina Bessi, Giuliano Binetti, Alessandra Bizarro, Rafael Blesa, Silvia Boschi, Paola Bossù, Geir Bråthen, Catherine Bresner, Henry Brodaty, Keeley J. Brookes, Luis Ignacio Brusco, Dolores Buiza‐Rueda, Katharina Bürger, Miguel Calero, Geneviève Chêne, Ángel Carracedo, Roberta Cecchetti, Laura Cervera‐Carles, Camille Charbonnier, Caterina Chillotti, Simona Ciccone, Jurgen A.H.R. Claassen, Christopher Clark, Elisa Conti, Anaïs Corma‐Gómez, Emanuele Maria Costantini, Carlo Custodero, Delphine Daian, Carolina Dalmasso, Efthimios Dardiotis, Jean‐François Dartigues, Peter Paul De Deyn, Teodoro del Ser, Nicola Denning, Janine Diehl‐Schmid, Mónica Díez-Fairén, Paolo Rossi, Srdjan Djurovic, Emmanuelle Duron, Ana Espinosa, Michael Ewers, Marta Fernández‐Fuertes, Catarina B. Ferreira, Evelyn Ferri, Bertrand Fin, Peter Fischer, Tormod Fladby, Klaus Fließbach, Juan Fortea, Silvia Fostinelli, Nick C. Fox, Emlio Franco-Macías, Ana Frank, Lutz Froelich, Sebastián García‐Madrona, Roberta Ghidoni, Giaccone Giorgio, Antonio González-Pérez, Giulia Grande, Emma Green, Timo Grimmer, Tamar Guetta‐Baranes, Annakaisa Haapasalo, Georgios M. Hadjigeorgiou, Harald Hampel, Annette M. Hartmann, Janet Harwood, Seppo Helisalmi, Michael T. Heneka, Martin J. Herrmann, Clive Holmes, Raquel Huerto Vilas, Marc Hulsman, Charlotte Johansson, Lena Kilander, Anne Kinhult Ståhlbom, Miia Kivipelto, Anne M. Koivisto, Johannes Kornhuber, Mary H. Kosmidis, Carmen Lage, Erika J. Laukka, Alessandra Lauria, Jenni Lehtisalo, Ondřej Lerch, Alberto Lleó, Malin Löwemark, Lauren Luckcuck, Juan Macı́as, Catherine Macleod, Wolfgang Maier, Francesca Mangialasche, Spallazzi Marco, Marta Marquié, Iain Marshall, Ángel Martín Montes, Carmen Martínez Rodríguez, Simon Mead, Miguel Medina, Silvia Mendoza, Manuel Menéndez‐González, Merel O. Mol, Laura Montrreal, Laura Morelli, Kevin Morgan, Markus M. Möthen, Carolina Muchnik, Tiia Ngandu, Robert Olaso, Adelina Orellana, Michela Orsini, Gemma Ortega, Alessandro Padovani, Alba Pérez‐Cordón, Pierre Péricard, Juan A. Pineda, Claudia Pisanu, Thomas Polak, Daniëlle Posthuma, Josef Priller, Olivier Quenez, Inés Quintela, Alberto Rábano, Inez Ramakers, Marcel Reinders, Peter Riederer, Natalia Roberto, Irene Rosas Allende, Maitée Rosende‐Roca, Elisa Rubino, María Eugenia Sáez, Paraskevi Sakka, Ingvild Saltvedt, Ángela Sanabria, María Bernal Sánchez‐Arjona, Florentino Sánchez-García, Sigrid Botne Sando, Michela Scamosci, Elio Scarpini, Matthias Schmid, Geir Selbæk, Olivia Anna Skrobot, Hilkka Soininen, Alina Solomon, Sandro Sorbi, Óscar Sotolongo‐Grau, Annika Spottke, Eystein Stordal, Juan Pablo Tartan, Lluís Tárraga, Niccoló Tesi, Anbupalam Thalamuthu, Latchezar Traykov, Anne Tybjærg‐Hansen, André G. Uitterlinden, Abbe Ullgren, Ingun Ulstein, Sergi Valero, Aad van der Lugt, Jasper Van Dongen, Jeroen van Rooij, Rik Vandenberghe, Jean‐Sébastien Vidal, Jonathan Vogelgsang, Michael Wagner, Leonie Weinhold, Gill Windle, Bob Woods, Mary Yannakoulia, Miren Zulaica, Jan Laczó, Václav Maťoška, María Serpente, Francesca Assogna, Fabrizio Piras, Valentina Ciullo, Jacob Shofany, Carlo Ferrarese, Simona Andreoni, Gessica Sala, C Zoia, Maria Del Zompo, Alberto Benussi, Patrizia Bastiani, Mari Takalo, Teemu Natunen, Tiina Laatikainen, Jaakko Tuomilehto, Riitta Antikaínen, Timo Strandberg, Jaana Lindström, Markku Peltonen, Nicholas Bass, Kristelle S. Brown, John Collinge, David W. Craig, Pangiotis Deloukas, Michael Gill, Rhian Gwilliam, John Hardy, Denise Harold, Paul Hollingworth, Jarret A. Johnston, Lesley Jones, Gill Livingston, Simon Lovestone, Michelle K. Lupton, Aoibhinn Lynch, David Mann, Bernadette McGuinness, Michael O‘Donovan, Michael J. Owen, Peter Passmore, John Powell, Christopher E. Shaw, A. David Smith, Hugh Gurling, Catherine J. Mummery, Nathalie Ryan, Giordano Lacidogna, Ad Adarmes-Gómez, Ana Mauleón, Ana Pancho, A. Gailhajenet, Asunción Lafuente, Daniel Macías‐García, Elvira Martín, Esther Pelejà, Isabel Sastre Merlín, L. Garrote-Espina, Liliana Vargas, Mario Carrión‐Claro, María Esmeralda Arreola Marín, Ma Labrador, Mar Buendía, M. D. Alonso, Marina Guitart, Mariona Moreno, Marta Ibarria, Mt Periñán, Núria Aguilera, Pilar Cañabate, R. Pineda-Sanchez, Silvia Jesús, Sílvia Preckler, Silvia Rodrigo‐Herrero, Susana Diego, Alessandro Vacca, Fausto Roveta, Nicola Salvadori, Elena Chipi, Henning Boecker, Christoph Laske, Robert Perneczky, Costas A. Anastasiou, Daniel Janowitz, Rainer Malik, Anna Anastasiou, Sara López‐García, Anna Antonell, Kalina Mihova, Diyana Belezhanska, Heike Weber, Silvia Kochen, Patricia Solís, Nancy Medel, Julieta Lisso, Zulma Sevillano, Daniel Gustavo Politis, Valeria Cores, Carolina Cuesta, Cecilia Ortíz, Juan Ignacio Bacha, Mario Rios, Aldo Saenz, Mariana Sanchez Abalos, Eduardo Köhler, Dana Lis Palacio, Ignacio Etchepareborda, Matias Köhler, Gisela V. Novack, Federico Ariel Prestia, Pablo Galeano, Eduardo M. Castaño, Sandra Germani, Carlos Reyes Toso, Matias Rojo, Carlos A. Ingino, Carlos A. Mangone, Sebastiaan Engelborghs, Fabrizio Tagliavini, Lucia Farotti, Chiara Fenoglio, Geert Jan Biessels, Seth Love, Christine Van Broeckhoven, David C. Rubinsztein, Stefan Teipel, Nathalie Fiévet, Vincent Deramecourt, Charlotte Forsell, Håkan Thonberg, Maria Bjerke, Ellen De Roeck, Nicholas G. Martin, Natividad Olivar, Mohsen Ghanbari, Perminder S. Sachdev, Karen A. Mather, M. Arfan Ikram, Tsolaki Magda, Cornelia M. van Duijn, Rebecca Sims, N. Aguilera, Estefanía Burgos Alarcón, Marie‐Annick Buendia, Amanda Cano, Arturo Corbatón Anchuelo, Itziar de Rojas, S. Diego, M. Guitart, A González-Péerez, A. Lafuente, Olalla Maroñas, Elisabeth Martin, M.T.M. Martinez, M. Moreno, Raúl Núñez‐Llaves, C. Olivé, E. Pelejà, ME Sáez, Manuel Serrano‐Ríos, L Táarraga, MD Alonso, G. Amer-Ferrer, M. Antequera, Carmen Antúnez, M. Bernal, MJ Bullido, Burguera Ja, MJ Casajeros, JM Cruz-Gamero, Marian M. de Pancorbo, Emilio Franco, JM García-Alberca, S. García Madrona, S. Hevilla, MA Labrador Espinosa, A. Legaz, A Lleóo, A Lóopez de Munáin, Salvadora Manzanares, Juan Marín-Muñoz, T Marín, B. Martínez, Carmen Martı́nez, Vicente Martı́nez, A Martínez-Lage Álvarez, J Péerez Tur, María Teresa Periñán, G. Piñol Ripoll, A Ráabano, Diego Real de Asúa, S. Rodrigo, JL Royo, R. Sanchez del Valle Díaz, Pascual Sánchez‐Juan, Isabel Sastre, MP Vicente, L. Vivancos, Shahram Bahrami, Ingunn Bosnes, Per Selnes, Sverre Bergh, Jacques Epelbaum, Didier Hannequin, Dominique Campion, Christophe Tzourio, Vincent Dermecourt, Alexis Brice, Bruno Dubois, Karen Ritchie, Amy L. Williams, Charlene Thomas, Chloe Davies, Will Nash, Kimberley Dowzell, Atahualpa Castillo-Morales, Mateus Bernardo-Harrington, James Turton, Jenny Lord, Kristelle Brown, Emma Vardy, Elizabeth Fisher, Jason D. Warren, Natalie S. Ryan, Rita Guerreiro, James Uphill, Reinhard Heun, Heike Kölsch, Britta Schürmann, ndré Lacour, Christine Herold, Janet Johnston, Yogen Patel, Angela Hodges, Tim Becker, Donald Warden, Gordon Wilcock, Robert Clarke, Yoav Ben‐Shlomo, Nigel M. Hooper, Stuart Pickering‐Brown, Rebecca Sussams, Andrew Singleton, Isabella Heuser, Dmitriy Drichel, Norman Klopp, Markus M. Nöthen, Manuel Mayhaus, Sabrina Pinchler, Thomas Feulner, Wei Gu, Hendrik den Bussche, Michael Hüll, Lutz Frölich, H‐Erich Wichmann, Karl‐Heinz Jöckel, John Kauwe, John C. Morris, Kevin H. Mayo, Michael J. Owen, Elaine Guo Yan Chew, Sun Ju Chung, Rong Peng, Yinxia Chao, Louis Tan, Moses Tandiono, Ebonne Ng, Kumar‐M. Prakash, Wing‐Lok Au, Wee-Yang Meah, Shi Qi Mok, Azlina Ahmad‐Annuar, Anne Chan, Ling Chen, Yongping Chen, Beom S. Jeon, Lulu Jiang, Jia Lun Lim, Juei‐Jueng Lin, Chun‐Feng Liu, Chengjie Mao, Vincent Mok, Zhong Pei, Huifang Shang, Changhe Shi, Kyuyoung Song, Ai Huey Tan, Yih‐Ru Wu, Yuming Xu, Renshi Xu, Yaping Yan, Jing Yang, Bao Rong Zhang, Woon‐Puay Koh, Shen‐Yang Lim, Chiea Chuen Khor, Jianjun Liu

Rattachement africain : fr, us, nl, ca, es, jp, sg, de, kr, be, it, se, ch, cz, fi, bg, pt, dk, gr, gb, no. Niveau de preuve : code pays fourni par la source.