Peter Passmore

Periodontitis and incident cognitive decline and dementia: A 15-year prospective cohort study of older men residing in Northern Ireland

Dominic Farsi, Gerard J. Linden, Gareth J. McKay, Claire T. McEvoy et autres

BackgroundPeriodontitis is a chronic bacterial infection that elicits systemic inflammation. While retrospective studies have linked periodontal pathogens with Alzheimer's disease (AD) and dementia, few have combined cognitive assessments, pathogen exposure, and inflammatory markers.ObjectiveTo investigate the longitudinal risk between periodontitis, cognitive impairment and …

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Low Hand Grip Strength Is Associated with Increased Risk of Cognitive Impairment in Older Men, Including Men with Probable Sarcopenic Obesity: Results from the Northern Ireland PRIME-COG Cohort

Gareth J. McKay, Michael McAlinden, Jessica L. Teeling, Peter Passmore et autres

Introduction: The relationship between cognitive impairment and a phenotype comprising low muscle strength coupled with excess adiposity, representative of sarcopenic obesity, is not well defined. The present study aimed to elucidate the relationship between low hand grip strength (HGS), representative of "probable …

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BRAIN-Diabetes: a randomised trial to test the feasibility of an adapted FINGER multidomain intervention in adults with type 2 diabetes living in rural border regions of Ireland

Claire T. McEvoy, Geraldine McCarthy, Rebecca F. Townsend, C. Dolan et autres

BACKGROUND: The Border Region Area lifestyle INtervention for healthy cognitive ageing in Diabetes' (BRAIN-Diabetes) trial aimed to test the feasibility of an adapted version of the Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) multidomain intervention in cognitively healthy …

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Unraveling the Role of Polyamine Metabolism in Postoperative Delirium: Insights into Biochemical Mechanisms and Biomarker Potential

Nazia Saiyed, Vaibhav Kumar Pandya, Xiaobei Pan, Miroslava Čuperlović‐Culf et autres

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Lessons from the PROTECT-CH COVID-19 platform trial in care homes

Philip M. Bath, Jonathan K. Ball, Matthew Boyd, Heather Gage et autres

Background: Coronavirus disease-2019 was associated with significant mortality and morbidity in care homes in 2020-1. Repurposed antiviral drugs might reduce morbidity and mortality through reducing viral transmission, infection, replication and inflammation. We aimed to compare the safety and efficacy of potential antiviral …

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Response to: Impact of potentially inappropriate medications on the risk of hospital admissions and emergency department visits in patients with dementia

Evi Zafeiridi, Leeanne O’Hara, Alan McMichael, Peter Passmore et autres

Dear editor, In response to the letter ‘Factors associated with hospital admissions in patients with dementia’, we appreciate the valid points that were raised about coexistent comorbidities and we will take them into account in future research. Unfortunately, we did not have …

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Hospital admissions and emergency department visits for people with dementia

Evi Zafeiridi, Alan McMichael, Leeanne O’Hara, Peter Passmore et autres

BACKGROUND: Previous studies have suggested that people with dementia (PwD) are more likely to be admitted to hospital, have prolonged hospital stay, or visit an emergency department (ED), compared to people without dementia. AIM: This study assessed the rates of hospital admissions …

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147 PRIME-COG study: grip strength, anthropometrics and cognitive decline

M. Gavan McAlinden, Gerard J. Linden, Gareth J. McKay, Claire T. McEvoy et autres

Abstract Background Measurement of hand grip strength is a validated measure of physical strength. While anthropometric measurements including waist, hip and mid-upper-arm circumference, are validated for physical health. Evidence has suggested grip strength and anthropometrics to be associated with cognitive impairment and …

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Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte et autres

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed …

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Emerging disease modifying therapies for older adults with Alzheimer disease: perspectives from the EuGMS special interest group in dementia

Adam H. Dyer, Helena Dolphin, Susan D. Shenkin, Tomas Welsh et autres

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Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Itziar de Rojas, Sonia Moreno–Grau, Niccoló Tesi, Benjamin Grenier‐Boley et autres

The original version of this Article omitted from the author list the 212th author Patrizia Mecocci, who is from the Institute of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. Consequently, the “Sample Contribution” section of Author Contributions was …

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Dementia with Lewy bodies post-mortem brains reveal differentially methylated CpG sites with biomarker potential

Xiaojian Shao, Sangeetha Vishweswaraiah, Miroslava Čuperlović‐Culf, Ali Yılmaz et autres

Dementia with Lewy bodies (DLB) is a common form of dementia with known genetic and environmental interactions. However, the underlying epigenetic mechanisms which reflect these gene-environment interactions are poorly studied. Herein, we measure genome-wide DNA methylation profiles of post-mortem brain tissue (Broadmann …

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