Accès ouvert déclaré
2018
article
Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
Gina M. Peloso, Sven J. van der Lee, Rebecca Sims, S.J. van der Lee, A.C. Naj, Céline Bellenguez, Nandini Badarinarayan, Jóhanna Jakobsdóttir, Brian W. Kunkle, Anne Boland, Rachel Raybould, JC Bis, Eden R. Martin, Benjamin Grenier‐Boley, Stefanie Heilmann‐Heimbach, Vincent Chouraki, Amanda Kuzma, Kristel Sleegers, Maria Vronskaya, Agustı́n Ruiz, Robert Graham, Robert Olaso, Per Hoffmann, M.L. Grove, Badri N. Vardarajan, Mikko Hiltunen, Markus M. Nöthen, Carlie White, K.L. Hamilton‐Nelson, Jacques Epelbaum, W. Maier, Samantha Choi, Gary W. Beecham, Cécile Dulary, Stefan Herms, Albert V. Smith, Christopher Funk, Andreas J. Forstner, Shahzad Ahmad, Hongliang Li, Delphine Bacq, Denise Harold, Claudia L. Satizábal, Otto Valladares, Alessio Squassina, J.A. Brody, Liming Qu, Pascual Sánchez‐Juan, Taniesha Morgan, Frank J. Wolters, Yi Zhao, F. García, Nicola Denning, Myriam Fornage, John Malamon, M.C.D. Naranjo, Elisa Majounie, Thomas H. Mosley, Beth A. Dombroski, David Wallon, Michelle K. Lupton, Josée Dupuis, Patrice Whitehead, Laura Fratiglioni, Christopher Medway, Shubhabrata Mukherjee, Lina Keller, Kathleen M. Brown, Henry J. Lin, L.B. Cantwell, Francesco Panza, Bernadette McGuinness, Sonia Moreno–Grau, Jeremy D. Burgess, Vincenzo Solfrizzi, Petroula Proitsi, Hieab H.H. Adams, Mariet Allen, Davide Seripa, Pau Pástor, L. Adrienne Cupples, Nathan D. Price, Didier Hannequin, Ana Frank, Daniel Levy, Prosanta Chakrabarty, Paolo Caffarra, Ina Giegling, Alexa Beiser, V. Giedraitis, Harald Hampel, M. Garcia, X. Wang, L. Lannfelt, Patrizia Mecocci, Gudny Eiriksdottir, Paul K. Crane, Florence Pasquier, Virginia Boccardi, Isabel Henández, Robert C. Barber, Martin Scherer, Ll. Tárraga, Perrie M. Adams, Markus Leber, Yuning Chen, Marilyn S. Albert, Steffi G. Riedel‐Heller, Valur Emilsson, Duane Beekly, Anne Braae, Rocío Patricia Mariaud Schmidt, Deborah Blacker, Carlo Masullo, Henry W. Schmidt, Rachelle S. Doody, Gianfranco Spalletta, W. T. Longstreth, Thomas Fairchild, Paola Bossù, Oscar L. López, Matthew P. Frosch, Eleonora Sacchinelli, Bernardino Ghetti, Qiong Yang, Ryan M. Huebinger, Frank Jessen, Shun Li, M. Ilyas Kamboh, John C. Morris, Óscar Sotolongo‐Grau, M Katz, Chris Corcoran, Melanie Dunstan, Amy Braddel, Charlene Thomas, Alun Meggy, Iain Marshall, Amy Gerrish, Jade Chapman, M. Aguilar, Sarah A. Taylor, Michael Hill, Mónica Díez-Fairén, Angela Hodges, Bruno Vellas, Hilkka Soininen, Iwona Kłoszewska, Makrina Daniilidou, James Uphill, Yash Patel, J.T. Hughes, Jenny Lord, James Turton, Arndt Hartmann, Roberta Cecchetti, Chiara Fenoglio, María Serpente, Marina Arcaro, Carlo Caltagirone, Maria Donata Orfei, Antonio Ciaramella, Sabrina Pichler, Manuel Mayhaus, Wei Gu, Alberto Lleó, Juan Fortea, Rafael Blesa, Imelda Barber, Keeley J. Brookes, Chiara Cupidi, Raffaele Maletta, David Carrell, Sandro Sorbi, Susanne Moebus, Mariana Ragassi Urbano, Alberto Pilotto, Johannes Kornhuber, Paola Bosco, S. Todd, David Craig, Janet Johnston, Michael Gill, Brian Lawlor, Aoibhinn Lynch, Nick C. Fox, John Hardy, Roger L. Albin, L.G. Apostolova, Steven E. Arnold, Sanjay Asthana, Craig Atwood, Clinton T. Baldwin, Lisa L. Barnes, Sandra Barral, Thomas G. Beach, JT Becker, Eileen H. Bigio, Thomas D. Bird, Bradley F. Boeve, James D. Bowen, Adam Boxer, James R. Burke, Jeffrey M. Burns, Joseph D. Buxbaum, N.J. Cairns, Chuanhai Cao, Christopher S. Carlson, Cynthia M. Carlsson, Regina M. Carney, Minerva M. Carrasquillo, Steven L. Carroll, C.C. Diaz, Helena C. Chui, David G. Clark, David H. Cribbs, E.A. Crocco, Charles DeCarli, Malcolm Dick, R. Duara, Denis A. Evans, Kelley M. Faber, K.B. Fallon, David W. Fardo, Martin R. Farlow, Steven H. Ferris, Tatiana M. Foroud, Douglas Galasko, Marla Gearing, Daniel H. Geschwind, J.R. Gilbert, NR Graff-Radford, R.C. Green, John H. Growdon, Ronald L. Hamilton, L. E. Harrell, Lawrence S. Honig, Matthew J. Huentelman, Christine M. Hulette, Bradley T. Hyman, Gail P. Jarvik, Erin L. Abner, Liwen Jin, Gyungah Jun, Anna Karydas, Jonathan Kaye, R. Kim, Neil W. Kowall, Julia Krämer, Frank M. LaFerla, James J. Lah, James B. Leverenz, Allan I. Levey, G. Li, A.P. Lieberman, Kathryn L. Lunetta, Constantine G. Lyketsos, Daniel Marson, Frank Martiniuk, Deborah C. Mash, Eliezer Masliah, W. C. McCormick, Susan M. McCurry, Andrew McDavid, Ann C. McKee, Marsel Mesulam, Bruce L. Miller, Carol A. Miller, Joshua W. Miller, Jill R. Murrell, A. J. W. Myers, Sid E. O’Bryant, J.M. Olichney, V. Shane Pankratz, J. E. Parisi, Henry L. Paulson, William Perry, Elaine R. Peskind, Anson Pierce, Wayne W. Poon, Huntington Potter, Joseph F. Quinn, Ashok Raj, Murray A. Raskind, Barry Reisberg, Christiane Reitz, J.M. Ringman, Erik D. Roberson, Ekaterina Rogaeva, Howard J. Rosen, Roger N. Rosenberg, Mark A. Sager, Andrew J. Saykin, Julie A. Schneider, L. S. Schneider, William W. Seeley, A.G. Smith, Joshua A. Sonnen, Salvatore Spina, Robert A. Stern, Russell H. Swerdlow, Rudolph E. Tanzi, Tricia A. Thornton‐Wells, J Q Trojanowski, Juan C. Troncoso, V.M. Van Deerlin, Linda J. Van Eldik, H.V. Vinters, Jean Paul Vonsattel, Sandra Weıntraub, Kathleen A. Welsh‐Bohmer, Jennifer Williamson, Thomas S. Wingo, Randall L. Woltjer, C.B. Wright, Chang‐En Yu, Lei Yu, Fabio Garzia, Feroze Golamaully, Gislain Septier, Sebastiaan Engelborghs, Rik Vandenberghe, Peter Paul De Deyn, C.M. Fernadez, Y.A. Benito, Håkan Thonberg, Charlotte Forsell, Lena Lilius, Anne Kinhult‐Ståhlbom, Lena Kilander, RoseMarie Brundin, Letizia Concari, Seppo Helisalmi, Anne M. Koivisto, Annakaisa Haapasalo, Vincent Dermecourt, Nathalie Fiévet, Olivier Hanon, Carole Dufouil, Alexis Brice, Karen Ritchie, Benjamin Dubois, J.J. Himali, C. Dirk Keene, JoAnn T. Tschanz, A.L. Fitzpatrick, Walter A. Kukull, Maria C. Norton, Thor Aspelund, Eric B. Larson, Ron Munger, Jerome I. Rotter, R.B. Lipton, María J. Bullido, Albert Hofman, Thomas J. Montine, Eliécer Coto, Eric Boerwinkle, Ronald Petersen, Victoria Álvarez, Fernando Rivadeneira, Eric M. Reiman, Maura Gallo, Christopher J. O’Donnell, Joan Reisch, Amalia C. Bruni, Donald R. Royall, Martin Dichgans, Mary Sano, Daniela Galimberti, Peter St George‐Hyslop, Elio Scarpini, Debby W. Tsuang, Michelangelo Mancuso, Ubaldo Bonuccelli, Ashley R. Winslow, Antonio Daniele, Chuang Wu, Oliver Peters, Benedetta Nacmias, Markus J. Riemenschneider, Reinhard Heun, Carol Brayne, D.C. Rubinsztein, José Brás, Rita Guerreiro, Ammar Al‐Chalabi, Christopher E. Shaw, John Collinge, David Mann, Magda Tsolaki, Jordi Clarimón, Rebecca Sussams, Simon Lovestone, Michael O‘Donovan, M J Owen, Timothy W. Behrens, Simon Mead, Alison Goate, André G. Uitterlinden, Clive Holmes, Carlos Cruchaga, Martin Ingelsson, David Bennett, Joseph E. Powell, Todd E. Golde, Caroline Graff, Philip L. De Jager, Kevin Morgan, Nilüfer Ertekin‐Taner, Onofre Combarros, Bruce M. Psaty, Peter Passmore, Steven G. Younkin, Claudine Berr, Vilmundur Guðnason, Dan Rujescu, Dennis W. Dickson, J.F. Dartigues, Anita L. DeStefano, Sara Ortega‐Cubero, Håkon Håkonarson, Dominique Campion, Merçé Boada, John Kauwe, Lindsay A. Farrer, Christine Van Broeckhoven, M. Arfan Ikram, Lesley Jones, Jonathan L. Haines, Christophe Tzourio, Lenore J. Launer, Valentina Escott‐Price, Richard Mayeux, J.-F. Deleuze, Najaf Amin, Peter Holmans, Margaret A. Pericak‐Vance, Philippe Amouyel, Cornelia M. van Duijn, Alfredo Ramı́rez, L.S. Wang, Jean‐Charles Lambert, Sudha Seshadri, Julie Williams, Gerald D. Schellenberg, Sudha Seshardi
2Citations signalées, ce qui n’est pas une note de qualité
6Institutions déclarées
2Pays d’affiliation déclarés
Rattachement africain : us, nl.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Abstract Introduction There is conflicting evidence whether high‐density lipoprotein cholesterol (HDL‐C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL‐C. We aimed to assess AD risk by genetically predicted HDL‐C. Methods Ten single nucleotide polymorphisms within the CETP locus predicting HDL‐C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR‐Egger. Results Based on 10 single nucleotide polymorphisms distinctly predicting HDL‐C in the CETP locus, we found that HDL‐C was not associated with risk of AD (P > .7). Discussion Our study does not support the role of HDL‐C on risk of AD through HDL‐C altered by CETP. This study does not rule out other mechanisms by which HDL‐C affects risk of AD.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genetically elevated high‐density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease
- Date Crossref
- 01/01/2018
- Éditeur
- Wiley
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Cholesterol and Lipid MetabolismGenetic Associations and EpidemiologyLipoproteins and Cardiovascular Health