Accès ouvert
2026
article
OpenAlex
Prabesh Bhattarai, Elanur Yılmaz, Elif Öykü Cakir, Hüseyin Tayran et autres
Blood-brain barrier (BBB) dysfunction is an early feature of Alzheimer's disease (AD) and is particularly pronounced in individuals carrying the APOE ε4 allele, but the mechanisms linking APOE ε4 to BBB failure remain unclear. Here we show that astrocyte-derived fibronectin (FN1) is …
us, fr, de, tr, cn
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Accès ouvert
2026
article
OpenAlex
Nuzulul Kurniansyah, Shinya Tasaki, Habbibur Rehman, Congcong Zhu et autres
Previously derived polygenic risk scores (PRSs) for Alzheimer’s disease (AD) perform inconsistently across diverse ancestries. We developed an APOE-independent multiancestry AD PRS using genome-wide association study summary statistics applied to European ancestry, African American, Caribbean Hispanic and East Asian cohorts. PRS performance …
us, kr
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Accès ouvert
2026
preprint
OpenAlex
Tamil Iniyan Gunasekaran, Dolly Reyes‐Dumeyer, Yian Y Gu, Olga Volpert et autres
Abstract Importance Alzheimer disease (AD) is frequently accompanied by co-pathologies such as Lewy bodies, intracellular protein aggregates consisting of misfolded α-synuclein, ubiquitin and several other proteins. These aggregated proteins contribute to the pathological and clinical heterogeneity of AD and are associated with …
us, Kenya
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Accès ouvert
2026
article
OpenAlex
Yian Gu, Lawrence S. Honig, Min Suk Kang, Dolly Reyes-Dumeyer et autres
Plasma-based phosphorylated tau 217 (P-tau217) has been increasingly used to identify Alzheimer disease (AD). However, discrepancies between P-tau217 levels and clinical diagnosis have been commonly seen, supporting a need to explore other pathologic pathways underlying the clinical symptoms. Furthermore, data are scarce …
us, do
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Accès ouvert
2026
preprint
OpenAlex
Min Qiao, Prabesh Bhattarai, Elanur Yılmaz, Alex Rookyard et autres
Abstract Background Alzheimer’s disease (AD) involves complex molecular alterations in the cerebrospinal fluid (CSF) proteome, yet the links between these protein changes and hallmark AD pathology remain incompletely defined. We investigated the relationship between the CSF proteome with CSF biomarkers of Alzheimer’s …
us, do
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Accès ouvert
2026
article
OpenAlex
Hyunmi Choi, José Gutierrez, Tian Wang, Minghua Liu et autres
OBJECTIVE: With the expected demographic shift toward those ≥65 years of age in the United States, late onset epilepsy (LOE) poses a significant public health issue, yet it has been historically understudied. We are undertaking an effort in the Epilepsy-Cog study to …
us
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Accès ouvert
2026
article
OpenAlex
Matthew W. Schelke, Anna C. Cai, Comana Cioroiu, Dina Dababneh et autres
Background and Objectives: Trainees provide a large proportion of neurologic care at academic medical centers in the United States. However, compared with their corresponding faculty practices, traditional trainee practices are often physically separate, serve primarily government-insured patients, and provide poorer continuity-of-care and …
us
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Accès ouvert
2026
article
OpenAlex
Moı̈se Desvarieux, Tatjana Rundek, Habibul Ahsan, Javier Narvaez et autres
Chronic diseases, including Alzheimer's disease (AD) and related dementia (ADRD), do not exist solely as isolated entities. Instead, they weave concomitant trajectories of multiple diseases, conditions, behaviors, and risks, mutually influencing each other's course and natural history, in ways yet unexplored. Electronic …
fr, us
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Accès ouvert
2026
preprint
OpenAlex
Yuexuan Xu, Tamil Iniyan Gunasekaran, Yian Y Gu, Dolly Reyes-Dumeyer et autres
ABSTRACT Background Plasma phosphorylated tau217 (P-tau217), a plasma biomarker of Alzheimer’s disease (AD), can increase before overt symptoms. P-tau217 positivity is linked to the age at symptom onset in model-based predictions, not time to clinical event. Individuals with different genetic backgrounds, yet …
us, do
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Accès ouvert
2026
article
OpenAlex
Mohamad J. Alshikho, Patrick J. Lao, Natalie C. Edwards, Jeffrey D. Pyne et autres
White matter hyperintensities (WMH) on T2-weighted brain magnetic resonance imaging (MRI) are common in aging and associated with small vessel cerebrovascular disease. Standard segmentation methods treat these lesions as uniform binary entities, fundamentally reducing WMH signal by flattening a complex spectrum of …
us
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Accès ouvert
2025
article
OpenAlex
Vrinda Kalia, Dolly Reyes‐Dumeyer, Saurabh Dubey, Hanisha Udhani et autres
Circulating metabolites can identify biochemical risk factors related to Alzheimer's disease (AD). We measured plasma metabolites in 1,068 participants of Caribbean Hispanic ancestry (250 patients with AD and 818 healthy controls) across 2 cohorts and analyzed their relationship with clinical AD, biomarker-supported …
us, do
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Accès ouvert
2025
article
OpenAlex
Olav M. Andersen, Matthijs W. J. de Waal, Giulia Monti, Niccoló Tesi et autres
BACKGROUND: Protein truncating variants (PTVs) in SORL1 are observed almost exclusively in Alzheimer’s Disease (AD) cases, but the effect of rare SORL1 missense variants is unclear. METHODS: To identify high-priority missense variants (HPVs), we applied ‘domain mapping of disease mutations’ for the …
dk, nl, us, pl, gb, fr, it, es, de, ca, se
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