[P2–527]: NORMATIVE ANALYSIS OF MINI MENTAL STATE EXAMINATION: A CROSS SECTIONAL STUDY IN A PREDOMINANTLY AFRICAN AMERICAN SAMPLE

Le résumé fourni par la source

Alzheimer's disease, the most common form of dementia, is an emerging public health crisis in African-Americans (AA)s. The incidence among those aged 65 and older is estimated to reach 6.9 million by the year 2030. To improve early diagnosis and treatment, an efficient screening tool, free of cultural bias is needed. While the Mini-Mental State Examination (MMSE) has been extensively used to screen for cognitive impairment, there is paucity of normative data on AAs across the cognitive spectrum. In particular, data on age and education adjusted norms are lacking in AAs. This creates an important challenge for clinical assessments, and the screening of AAs into clinical trials. Objective of Study: In this study, we describe the normative MMSE value in a predominantly AA sample. We sought to further inform performance on the MMSE, cognizant of adjustment for the effects of age and education, and potentially, improve its efficiency in AAs. Data used in these analyses were obtained from 3,391 potential volunteers (Blacks=2,532), aged ≥ 50, screened for 16 different clinical studies on Alzheimer's disease (AD). As part of the screening procedure, volunteers completed the MMSE at various recruitment sites. The mean age for the entire sample was 70.37±13.35 years, and included greater proportion of women (71.08%) than men. Mean MMSE scores increased with years of education regardless of age group, but decreased with increasing age, while the ≤ 12 years of education group had performed poorest. For the initial unadjusted estimates, Whites had the highest mean MMSE score (AAs=27.16±3.43; Whites=27.62±3.12; Hispanics=25.40±4.72; Asians=26.85±3.01; Others=26.98±2.70), With adjustments for age and education, race-related differences in MMSE score became attenuated (AAs=26.26±3.13; Whites=26.17±3.32; Hispanics=24.73±4.49; Asians=25.61±2.87; Others=26.01±2.80), except for Hispanics whose MMSE score remained relatively lower.

Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.