Thomas V. Fungwe

Molecular signatures of lipid peroxidation in cardiomyopathy: unraveling oxidative mechanisms in cardiac cell dysfunction

Tahar Hajri, Thomas V. Fungwe

Cardiomyopathy, like other major cardiovascular diseases, is becoming increasingly prevalent and represents a growing public health challenge. Although both genetic and acquired factors contribute to its development, obesity and diabetes remain among the most significant modifiable risks. These conditions share key pathological …

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Impact of Lipid Oxidation Products on Inflammation and Insulin Resistance: A Focus on Mechanisms of Action

Tahar Hajri, Khadija Ouguerram, Thomas V. Fungwe

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Investigating the Effect of Seaweed Bioactive Compounds on Gut Microbiota Composition and Dysbiosis: A Systematic Review

Miriam Hagan, Thomas V. Fungwe

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Investigating the effect of seaweed bioactive compounds on gut microbiota composition and dysbiosis: a systematic review

Miriam Hagan, Thomas V. Fungwe

The gut microbiota is a complex ecosystem that maintains a symbiotic relationship with the host metabolism, immune development, and intestinal balance. Diet and environmental factors influence the gut microbiota composition, as a disruption in microbiota due to a range of possible diseases …

Additive Effects of Turmeric Forte Supplement on type-2 Diabetes Mellitus in Sprague Dawley Rats Fed Nauclea Latifolia Root Extracts

Muzaynah Al Khairat, Abdullah A. Otayf, O. Ntekim, Charlotte Castor et autres

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Abstract Tu127: Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein induced oxidative stress and insulin resistance.

Tahar Hajri, Mohamed Gharib, Thomas V. Fungwe

Background: Very-low-density lipoprotein receptor (VLDLR), a member of the LDL receptor family, binds and increases the catabolism of triglyceride–rich lipoproteins. Although VLDLR is highly expressed in the heart, its role in VLDLR in oxidative stress and insulin resistance is unclear. Here, we …

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Seaweed Consumption and Weight Management: Exploring the Anti-obesity Effects of Seaweed Vegetables on Adults With Obesity – A Systematic Review

Miriam Hagan, Thomas V. Fungwe

of FMI (70.83%).Moreover, the YI revealed that the BMI cut-off point yielding the highest sensitivity (97.67%) and specificity (100%) was >25.4 kg/m 2 based on PBF.Conversely, a BMI cutoff point of >29.4 kg/m 2 demonstrated a sensitivity and specificity of 86.6% and …

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Very low-density lipoprotein receptor mediates triglyceride-rich lipoprotein-induced oxidative stress and insulin resistance

Tahar Hajri, Mohamed Gharib, Thomas V. Fungwe, Amosy E. M’Koma

Obesity is associated with excess lipid deposition in muscles, which is considered as a leading cause of metabolic dysfunction and oxidative stress. Cellular uptake of lipids is regulated by several membrane receptors, among which is the very low-density lipoprotein receptor (VLDLR). This …

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Effectiveness of Qualitative and Quantitative Instruments in Assessment and Evaluation of Community Based Nutrition Education Programs

O. Udenyi, Charlotte Castor, Linda Thompson, Thomas V. Fungwe et autres

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Determining the effect of seaweed intake on the microbiota: a systematic review

Miriam Hagan, Thomas V. Fungwe

The human gut microbiota is dominated by bacteria, and the host dietary intake is one factor that can modulate the diversity of the gut microbiota to health or diseases. According to the FAO, there is an annual steady decline in agricultural practices …

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Systolic Blood Pressure Is Associated with Increased Brain Amyloid Load in Mild Cognitively Impaired Participants: Alzheimer’s Disease Neuroimaging Initiatives Study

Thomas V. Fungwe, Julius S. Ngwa, Steven P. Johnson, Jilian V. Turner et autres

BACKGROUND: Cardiovascular disease (CVD), including elevated blood pressure (BP), is known to promote Alzheimer's disease (AD) risk. Although brain amyloid load is a recognized hallmark of pre-symptomatic AD, its relationship to increased BP is less known. The objective of this study was …

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The Role of Transportation in the Enrollment of Elderly African Americans into Exercise and Memory Study: GEMS Study

Lennox Graham, Julius S. Ngwa, Oyonumo Ntekim, Oludolapo Ogunlana et autres

BACKGROUND: Understanding the factors driving recruitment and enrollment of African Americans (AA)s in clinical translational research will assure that underrepresented populations benefit from scientific progress and new developments in the diagnosis and treatment of Alzheimer's disease and related disorders. While transportation is …

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