Accès ouvert déclaré
2017
conference-abstract
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
G. Todd Milne, Peter Sandner, Kathleen Lincoln, Paul Carter Harrison, Hongxing Chen, Hong Wang, Holly D. Clifford, Hu Sheng Qian, Diane Wong, Chris Sarko, Ryan M. Fryer, Jeremy G. Richman, Glenn A. Reinhart, Carine Boustany, Steven S. Pullen, Henriette Andresen, Alessandro Cataliotti, Finn Olav Levy, Robert Łukowski, Sandra Frankenreiter, Timothy Dean Calamaras, R. Baumgärtner, Angela L. McLaughlin, Mark A. Aronovitz, Wendy E. Baur, Guangrong Wang, Navin Kumar Kapur, Richard H. Karas, Robert M. Blanton, Stefan W. Hell, Scott Arthur Waldman, Jieru Egeria Lin, Francheska Colón‐González, Gilbert W. Kim, Erik Scott Blomain, Dante J. Merlino, Adam Eugene Snook, Jeanette Erdmann, Jana Wobst, Thorsten Kessler, Heribert Schunkert, Ulrich Walter, Oliver Pagel, Elena Walter, Stepan P. Gambaryan, Albert Smolenski, Kerstin Jurk, René Peiman Zahedi, James R. Klinger, Raymond L. Benza, Paul A. Corris, David Langleben, Robert Naeije, Gérald Simonneau, Christian Meier, Pablo C. Colorado, Mi Kyung Chang, Dennis Busse, Marius M. Hoeper, Jaime L. Masferrer, Sarah Jacobson, Renee Sarno, Sylvie G. Bernier, Ping Zhang, Roger Flores‐Costa, Mark G. Currie, Katherine C. Hall, Dorit Möhrle, Katrin Reimann, Steffen Wolter, Markus Wolters, Evanthia Mergia, Nicole Eichert, Hyun-Soon Geisler, Peter Ruth, Andreas Friebe, Robert Feil, Ulrike Zimmermann, Marlies Knipper, Lukas Rüttiger, Yasutake Tanaka, Atsuko Okamoto, Motofumi Kumazoe, Takeshi Tokudome, Koichi Miura, Jun Hino, Mikiya Miyazato, Kenji Kangawa, Vikas Kapil, Amrita Ahluwalia, Nazareno Paolocci, Philip Eaton, James C. Campbell, Philipp Henning, Eugen Franz, Banumathi Sankaran, Friedrich W. Herberg, Choel Kim, Matthias Wittwer, Luo Qi, Ville R. I. Kaila, Sonja A. Dames, Andrew B. Tobin, Mahmood M. Alam, Olena Rudyk, Susanne Krasemann, Kristin Hartmann, Oleksandra D. Prysyazhna, Min Zhang, Lan Zhao, Astrid Weiß, RALPH THEO SCHERMULY, Amie J. Moyes, Sandy M. Chu, Reshma S. Baliga, Adrian J. Hobbs, Stylianos Michalakis, Regine Mühlfriedel, Christian Schön, Dominik M. Fischer, Barbara Wilhelm, Ditta Zobor, Susanne Kohl, Tobias M. Peters, Eberhart Zrenner, Karl Ulrich Bartz‐Schmidt, Marius Ueffing, Bernd Wissinger, Mathias W. Seeliger, Martin Biel, Mark John Ranek, Kristen M. Kokkonen-Simon, Dong I. Lee, Ronald J. Holewinski, Vineet Agrawal, Cornelia Virus, Donté Alexander Stevens, Masayuki Sasaki, Huaqun Zhang, Mathew M. Mannion, Peter P. Rainer, Richard C. Page, Jonathan Cummings Schisler, Jennifer E. Van Eyk, Monte S. Willis, David A. Kass, Michael Russwurm, Jan Giesen, Corina Russwurm, Ernst‐Martin Füchtbauer, Nadja I. Bork, Luís Agulló, Martin Floor, Ornella Manfra, Gaia Calamera, Nicoletta Concetta Surdo, Silja Meier, Alexander Froese, Viacheslav O. Nikolaev, Kjetil Wessel Andressen, Annemarie Aue, Fabian Schwiering, Dieter Groneberg, Gzona Bajraktari‐Sylejmani, Jürgen Burhenne, Walter E. Haefeli, Johanna Weiß, Katharina Beck, Barbara Voußen, Alexander D. Vincent, Jan D. Huizinga, Fabíola Z. Mónica, Edward Seto, Ferid Murad, Ka Bian, Joseph Robert Burgoyne, Daniel A. Richards, Marianne Bjørnerem, Andrea Hembre Ulsund, Jeong Joo Kim, Sonia Donzelli, Mara R. Goetz, Kjestine Schmidt, Konstantina Stathopoulou, Jenna Scotcher, Christian Dees, Hariharan Subramanian, Elke Butt, Alisa Kamynina, S. Bruce King, Cor de Witt, Lars Ingo Ole Leichert, Friederike Cuello, Hyazinth Dobrowinski, Moritz Lehners, Michael Paolillo Hannes Schmidt, Susanne C. Feil, Lai Wen, Martin Thunemann, Marcus Olbrich, Harald F. Langer, Meinrad Gawaz, Cor de Wit, Daniela Bertinetti, Friedrich Grimminger, Ekkehard Grünig, Yigao Huang, Pavel Jansa, Zhi‐Cheng Jing, D Kilpatrick, Stephan Rosenkranz, Flavia Menezes, Arno Fritsch, Sylvia M. Nikkho, Reiner Frey, Marc Humbert, Manuela Harloff, Jörg Reinders, Jens Schlossmann, Joon O. Jung, Jessica A. Wales, Cheng‐Yu Chen, Linda A. Breci, Andrzej Weichsel, Robert M. Solinga, Paul A. Renhowe, W.R. Montfort, Liying Qin, Ying‐Ju Sung, Darren E. Casteel, Alexander Kollau, Andrea Neubauer, Astrid Schrammel, Bernd Mayer, Mika Takai, Chieri Takeuchi, Mai Kadomatsu, Shun Hiroi, Kanako Takamatsu, Hirofumi Tachibana, Marissa Opelt, Emrah Eroğlu, Markus Waldeck‐Weiermair, Doris Koesling, Roland Malli, Wolfgang F. Graier, John Tollen Fassett, Selene J. Sollie, Maria Hernandez-Valladares, Frode S. Berven, Takashi Nojiri, Miki Arai, Yutaka Suzuki, Meinoshin Okumura, Shinpei Kawaoka, Stefanie Peters, Hannes Schmidt, Selin Kenet, Sarah Helena Nies, Katharina Frank, Fritz G. Rathjen, Olga N. Petrova, Isabelle Lamarre, Michel Négrerie, Jerid W. Robinson, Jeremy R. Egbert, Julia O. Davydova, Laurinda A. Jaffe, Lincoln Ross Potter, Nicholas C. Blixt, Leia C. Shuhaibar, Gordon L. Warren, Kim C. Mansky, Simone Romoli, Tobias Bauch, Karoline Dröbner, Frank Eitner, Mihály Ruppert, Tamás Radovits, Sevil Korkmaz‐Icöz, Shiliang Li, Péter Hegedűs, Sivakanan Loganathan, Balázs Tamás Németh, Attila Oláh, Csaba Mátyás, Kálmán Benke, Béla Merkely, Matthias Karck, Gabor B. Szabo, U. Scheib, Matthias Broser, Shatanik Mukherjee, Katja Stehfest, Christine Elizabeth Gee, Heinz G. Körschen, Thomas G. Oertner, Peter Hegemann, Deborah M. Dickey, Alexandre Dumoulin, Ralf Kühn, Sophie Schobesberger, Peter Wright, Claire E. Poulet, Catherine A. Mansfield, Siân E. Harding, Julia Gorelik, Gerald Wölkart, Antonius C.F. Gorren, Gerburg K. Schwaerzer, Nancy D. Dalton, Yusu Gu, Shunhui Zhuang, Dianna M. Milewicz, Kirk L. Peterson, Renate B. Pilz, Aikaterini I. Argyriou, Garyfalia Makrynitsa, Ioannis I. Alexandropoulos, Andriana Stamopoulou, Marina Bantzi, Athanassios Giannis, Stavros Topouzis, Andreas Papapetropoulos, Georgios A. Spyroulias, Dennis J. Stuehr, Arnab Ghosh, Yue Dai, Saurav Misra, Boris Tchernychev, Inmaculada Silos‐Santiago, Gerhard Hannig, Vu Thao-Vi Dao, Martin Deile, Pavel I. Nedvetsky, Andreas Güldner, César Ibarra‐Alvarado, Axel Gödecke, Harald H.H.W. Schmidt, Angelos Vachaviolos, Andrea Gerling, Stefan Zoltan Lutz, Hans-Ulrich Häring, Marcel A. Krüger, Bernd J. Pichler, Michael J. Shipston, Sara Vandenwijngaert, Clara D. Ledsky, Obiajulu Agha, Dongjian Hu, Ibrahim John Domian, Emmanuel S. Buys, Christopher Newton‐Cheh, Donald B. Bloch, Nadine Mauro, Jonas Keppler, Wilson A. Ferreira, Hanan Chweih, Pâmela L. Brito, Camila Bononi Almeida, Carla Fernanda Franco Penteado, Sara S. O. Saad, Fernando Ferreira Costa, Paul S. Frenette, Damian Brockschnieder, Johannes‐Peter Stasch, Nicola Conran, Daniel P. Zimmer, Jenny V. Tobin, Courtney M. Shea, Kimberly K. Long, Kim San Tang, Peter Germano, JAMES D. WAKEFIELD, Ali R. Banijamali, G-Yoon Jamie Im, Albert T. Profy
16Citations signalées, ce qui n’est pas une note de qualité
109Institutions déclarées
20Pays d’affiliation déclarés
Rattachement africain : us, de, no, ie, gb, ca, be, fr, es, jp, dk, cn, cz, au, at, hu, gr, nl, mx, br.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with and enhance endogenous NO signaling.As such, sGC stimulators may provide therapeutic benefits both in diseases associated with impaired NO signaling and in diseases where stimulation of this pathway will restore functional homeostasis.Data from our recent preclinical studies add to the growing body of evidence that sGC stimulators have direct effects on systemic and vascular inflammation, fibrosis, and metabolism.Ironwood is developing IW-1973 and IW-1701 as oral, once-daily sGC stimulators for both cardiovascular and non-cardiovascular systemic disease indications.Phase 1 studies in healthy human subjects demonstrated clear evidence of target engagement, attractive pharmacokinetic properties, and predicted hemodynamic effects, at well-tolerated doses.Phase 2 studies are currently ongoing in patients with achalasia, an esophageal motility disorder, and in patients with diabetes and hypertension.Preclinical characterization of IW-1973 and IW-1701 support the broad therapeutic potential and multi-faceted pharmacology of these compounds.Based on preclinical studies, IW-1973 has extensive distribution into organs including liver, heart, kidney, and lung, which may maximize effects on target organs while limiting systemic hemodynamic effects.The pharmacokinetic profile of IW-1701 has a narrow peak-to-trough ratio, which may provide more consistent pharmacological effect throughout the dosing interval.Ironwood is also developing IW-6463, a novel, CNS-penetrant sGC stimulator that shows target engagement and effects on regional blood flow in the brain.Preclinical data suggest that IW-6463 may be useful in treating CNS disorders including vascular dementia and Alzheimer's disease.We believe that sGC stimulation, alone or in combination with other mechanisms, may afford therapeutic benefit in multiple diseases.Furthermore, there may be an opportunity to provide targeted treatments by selecting compounds that are well-suited for specific diseases based on pharmacological profile, tissue distribution, pharmacokinetics, and route of administration. Competing interest
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications
- Date Crossref
- 01/10/2017
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Ironwood Pharmaceuticals (United States)
pays non établi dans la notice
Entreprise
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Bayer (Germany)
pays non établi dans la notice
Entreprise
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Boehringer Ingelheim (United States)
pays non établi dans la notice
Entreprise
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Oslo University Hospital
Department of Pharmacology
pays non établi dans la notice
Établissement de santé
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University of Oslo
pays non établi dans la notice
Université ou école supérieure
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University of Tübingen
pays non établi dans la notice
Université ou école supérieure
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University of Würzburg
pays non établi dans la notice
Université ou école supérieure
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Tufts Medical Center
pays non établi dans la notice
Établissement de santé
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German Cancer Research Center
pays non établi dans la notice
Structure de recherche
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Heidelberg University
pays non établi dans la notice
Université ou école supérieure
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Max Planck Institute for Biophysical Chemistry
pays non établi dans la notice
Structure de recherche
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Thomas Jefferson University
Department of Pharmacology and Experimental Therapeutics
pays non établi dans la notice
Université ou école supérieure
Ironwood Pharmaceuticals (United States), Bayer (Germany) et Boehringer Ingelheim (United States), avec 9 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Phosphodiesterase function and regulation