Accès ouvert
2021
article
OpenAlex
Timothy Dean Calamaras, Suchita Pande, R. Baumgärtner, Seung Kyum Kim et autres
cGMP-dependent protein kinase 1α (PKG1α) promotes left ventricle (LV) compensation after pressure overload. PKG1-activating drugs improve heart failure (HF) outcomes but are limited by vasodilation-induced hypotension. Signaling molecules that mediate PKG1α cardiac therapeutic effects but do not promote PKG1α-induced hypotension could therefore …
us
(code pays fourni par la source)
2019
paratext
OpenAlex
Markus May, Michael A. Baumann, R. Baumgärtner, Tobias Eder
2019
conference-paper
OpenAlex
Aulia Saputra Azhar, Ole Neitz, Josef Knapp, R. Baumgärtner et autres
Standard radar imaging methods work commonly with time-domain or spectral domain back-propagation techniques, which are restricted in terms of flexibility and spatial resolution. In this work, we investigate inverse source methods with respect to their imaging capabilities. In an inverse source method, …
de
(code pays fourni par la source)
2019
conference-abstract
OpenAlex
Timothy Dean Calamaras, R. Baumgärtner, Mark J. Aronovitz, Joseph C. McCarthy et autres
Background: Mixed lineage kinase 3 (MLK3) opposes pathologic cardiac remodeling, but its role in blood pressure (BP) has not been studied. MLK3 activates JNK signaling through kinase-dependent effects, and opposes RhoA activation through kinase-independent mechanisms, but the relevance of these mechanisms to …
us
(code pays fourni par la source)
2019
article
OpenAlex
Timothy Dean Calamaras, R. Baumgärtner, Mark J. Aronovitz, Joseph C. McCarthy et autres
us
(code pays fourni par la source)
Accès ouvert
2019
conference-paper
OpenAlex
Sarah F. Griffin, Lloyd W. Daly, M. R. Lee, L. V. Forman et autres
Accès ouvert
2018
article
OpenAlex
Timothy Dean Calamaras, R. Baumgärtner, Mark J. Aronovitz, Angela L. McLaughlin et autres
Myocardial hypertrophy is an independent risk factor for heart failure (HF), yet the mechanisms underlying pathological cardiomyocyte growth are incompletely understood. The c-Jun NH2-terminal kinase (JNK) signaling cascade modulates cardiac hypertrophic remodeling, but the upstream factors regulating myocardial JNK activity remain unclear. …
us
(code pays fourni par la source)
Accès ouvert
2018
article
OpenAlex
R. Baumgärtner, Adam Fitch, Barbara A. Methé, Kelvin Li et autres
us
(code pays fourni par la source)
Accès ouvert
2017
conference-abstract
OpenAlex
G. Todd Milne, Peter Sandner, Kathleen Lincoln, Paul Carter Harrison et autres
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with and enhance endogenous NO …
us, de, no, ie, gb, ca, be, fr, es, jp
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
R. Baumgärtner, Guangrong Wang, Navin Kumar Kapur, Gordon S. Huggins et autres
us
(code pays fourni par la source)
2016
conference-abstract
OpenAlex
Timothy Dean Calamaras, R. Baumgärtner, Guangrong Wang, Angela M. Lane et autres
Background: cGMP-dependent protein kinase G I α (PKGIα) via its leucine zipper (LZ) domain prevents adverse cardiac remodeling. Identifying and characterizing PKGIα-LZ dependent substrates may reveal novel therapeutic targets in the myocardium. We previously identified the LZ-containing Mixed Lineage Kinase 3 (MLK3) …
us, de
(code pays fourni par la source)
Accès ouvert
2016
article
OpenAlex
Sean D. Pokorney, Jonathan Paul Piccini, Susanna R. Stevens, Manesh R. Patel et autres
BACKGROUND: Atrial fibrillation is associated with higher mortality. Identification of causes of death and contemporary risk factors for all-cause mortality may guide interventions. METHODS AND RESULTS: In the Rivaroxaban Once Daily Oral Direct Factor Xa Inhibition Compared with Vitamin K Antagonism for …
us, de, au, gb
(code pays fourni par la source)