Deborah M. Dickey

Lipid-derived electrophiles induce carbonyl stress, mitochondrial dysfunction, and cellular senescence: 4-hydroxynonenal as a physiological determinant of adipose senescence in obesity and aging

Thomas Blake Monroe, Ann Vogel Hertzel, Deborah M. Dickey, Thomas Hagen et autres

us (code pays fourni par la source)

Expression of fatty acid binding proteins in mesenteric adipose tissue

Shayla R. Fish, Catherine L. Halley, Mythili Dileepan, Ann Vogel Hertzel et autres

us (code pays fourni par la source)

Lipid peroxidation products induce carbonyl stress, mitochondrial dysfunction, and cellular senescence in human and murine cells

Thomas Blake Monroe, Ann Vogel Hertzel, Deborah M. Dickey, Thomas Hagen et autres

Abstract Lipid enals are electrophilic products of lipid peroxidation that induce genotoxic and proteotoxic stress by covalent modification of DNA and proteins, respectively. As lipid enals accumulate to substantial amounts in visceral adipose during obesity and aging, we hypothesized that biogenic lipid …

us (code pays fourni par la source)

Role for BLT1 in regulating inflammation within adipose tissue immune cells of aged mice

Wei-Ching Shih, In Hwa Jang, Victor Kruglov, Deborah M. Dickey et autres

BACKGROUND: Aging is a complex biological process characterized by obesity and immunosenescence throughout the organism. Immunosenescence involves a decline in immune function and the increase in chronic-low grade inflammation, called inflammaging. Adipose tissue expansion, particularly that of visceral adipose tissue (VAT), is …

us (code pays fourni par la source)

Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation

Henriette Andresen, Cristina Pérez‐Ternero, Jerid W. Robinson, Deborah M. Dickey et autres

Abstract Background and Purpose Guanylyl cyclase‐A (GC‐A), activated by endogenous atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), plays an important role in the regulation of cardiovascular and renal homeostasis and is an attractive drug target. Even though small molecule modulators …

no, gb, us, bd (code pays fourni par la source)

Inflammasome Activation and Pyroptosis via a Lipid-regulated SIRT1-p53-ASC Axis in Macrophages From Male Mice and Humans

Yimao Huang, Peter Yong, Deborah M. Dickey, Setu M. Vora et autres

Obesity-linked diabetes is associated with accumulation of proinflammatory macrophages into adipose tissue leading to inflammasome activation and pyroptotic secretion of interleukin (IL)-1β and IL-18. Targeting fatty acid binding protein 4 (FABP4) uncouples obesity from inflammation, attenuates characteristics of type 2 diabetes and …

ru, us (code pays fourni par la source)

Novel enhancers of guanylyl cyclase-A activity via allosteric modulation

Henriette Andresen, Cristina Pérez‐Ternero, Jerid W. Robinson, Deborah M. Dickey et autres

ABSTRACT Natriuretic peptide receptor (NPR)-A (also known as NPR-A, NPR1 or guanylyl cyclase-A, GC-A) is an attractive but challenging target to activate with small molecules. GC-A is activated by endogenous atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), and this activation …

no, gb, us (code pays fourni par la source)

Fatty acid binding protein 4 regulates pancreatic cancer cell proliferation via activation of nuclear factor E2-related factor 2

Keith M. Wirth, Shuhei Shinoda, Mizuho Sato‐Dahlman, Deborah M. Dickey et autres

us (code pays fourni par la source)

Abstract 12619: Macrophage-Dependent Interleukin-1 Beta Secretion (IL-1β) Induces Diabetic Diastolic Dysfunction

Hong Liu, Yimao Huang, Gyeoung-Jin Kang, Feng Feng et autres

Introduction: Diabetes mellitus (DM) is a main risk factor for diastolic dysfunction (DD), the underlying pathological condition of heart failure with preserved ejection fraction (HFpEF). Nevertheless, the mechanism linking DM and DD is unclear. DM causes a low level inflammatory response, and …

us (code pays fourni par la source)

Multiomic Profiling of Tyrosine Kinase Inhibitor-Resistant K562 Cells Suggests Metabolic Reprogramming To Promote Cell Survival

Brett Noel, Steven B. Ouellette, Laura J. Marholz, Deborah M. Dickey et autres

Resistance to chemotherapy can occur through a wide variety of mechanisms. Resistance to tyrosine kinase inhibitors (TKIs) often arises from kinase mutations-however, "off-target" resistance occurs but is poorly understood. Previously, we established cell line resistance models for three TKIs used in chronic …

us (code pays fourni par la source)

Regulation of the Natriuretic Peptide Receptor 2 (Npr2) by Phosphorylation of Juxtamembrane Serine and Threonine Residues Is Essential for Bifurcation of Sensory Axons

Hannes Schmidt, Deborah M. Dickey, Alexandre Dumoulin, Marie Octave et autres

cGMP signaling elicited by activation of the transmembrane receptor guanylyl cyclase Npr2 (also known as guanylyl cyclase B) by the ligand CNP controls sensory axon bifurcation of DRG and cranial sensory ganglion (CSG) neurons entering the spinal cord or hindbrain, respectively. Previous …

de, us (code pays fourni par la source)

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

G. Todd Milne, Peter Sandner, Kathleen Lincoln, Paul Carter Harrison et autres

The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with and enhance endogenous NO …

us, de, no, ie, gb, ca, be, fr, es, jp (code pays fourni par la source)