Accès ouvert
2017
conference-abstract
OpenAlex
G. Todd Milne, Peter Sandner, Kathleen Lincoln, Paul Carter Harrison et autres
The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) signalling pathway plays a fundamental role in modulating diverse physiological processes including blood flow, fibrosis, inflammation, and metabolism.sGC stimulators are small-molecule, heme-dependent agonists of sGC that synergize with and enhance endogenous NO …
us, de, no, ie, gb, ca, be, fr, es, jp
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Accès ouvert
2017
article
OpenAlex
Martin Thunemann, Barbara F. Schörg, Susanne C. Feil, Yun Lin et autres
Many pathophysiological processes are associated with proliferation, migration or death of distinct cell populations. Monitoring specific cell types and their progeny in a non-invasive, longitudinal and quantitative manner is still challenging. Here we show a novel cell-tracking system that combines Cre/lox-assisted cell …
us, de
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Accès ouvert
2013
article
OpenAlex
Lai Wen, Martin Thunemann, Susanne C. Feil, Matthias Hillenbrand et autres
Sensor proteins that detect cGMP are valuable tools to analyse the molecular mechanisms underlying cGMP’s manifold physiological functions. These cGMP sensors allow for visualization and quantification of cGMP in living cells, in real time, and at high spatial and temporal resolution. For …
de, us
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Accès ouvert
2013
article
OpenAlex
Martin Thunemann, Lai Wen, Matthias Hillenbrand, Angelos Vachaviolos et autres
RATIONALE: Cyclic GMP (cGMP) is an important intracellular signaling molecule in the cardiovascular system, but its spatiotemporal dynamics in vivo is largely unknown. OBJECTIVE: To generate and characterize transgenic mice expressing the fluorescence resonance energy transfer-based ratiometric cGMP sensor, cGMP indicator with …
de
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