Accès ouvert déclaré
2013
article
Acute Cerebrovascular Disease in the Young
Arndt Rolfs, Franz Fazekas, Ulrike Grittner, Martin Dichgans, Peter Martus, Martin Holzhausen, Tobias Böttcher, Peter U. Heuschmann, Turgut Tatlisumak, Christian Tanislav, Gerhard J. Jungehülsing, Anne‐Katrin Giese, J Putaala, Roman Huber, Ulf Bodechtel, Christoph Lichy, Christian Enzinger, Reinhold Schmidt, Michael G. Hennerici, Manfred Kaps, Christof Kessler, Karl J. Lackner, Eduard Paschke, Wolfgang Meyer, Hermann Mascher, Olaf Rieß, Edwin H. Kolodny, Bo Norrving, A. Rolfs, Mindy Ginsberg, MG Hennerici, Ringelstein Eb, P M Rothwell, G.S. Venables, Natan M. Bornstein, PP DeDeyn, Hugh S. Markus, Carla Biedermann, K. Brüderlein, Jason Burmeister, I Federow, Franz König, G Makowei, David Niemann, Stuart Rosner, Susanne Zielke, Stefan Ropele, Manfred Windisch, Eila Sterner, Olaf A. Bodamer, Andreas Fellgiebel, Uwe Hillen, Lisa Jonas, C. Kampmann, Peter Kropp, Michael Laue, Frank Weidemann, Jörg Berrouschot, Anett Stoll, A Rokicha, C Sternitzky, Mathis Thoma, Rishi Sheorajpanday, Isabel De Brabander, Laetitia Yperzeele, Raf Brouns, Patrick Oschmann, M. Pott, Kathrin Schultes, Cornelia Schultze, J Hirsekorn, GJ Jungehülsing, Arno Villringer, W. U. Schmidt, Thomas Liman, Tim Nowe, Martin Ebinger, Andreas Wille, HOLLYANN LOUI, A Objartel, Anett Übelacker, Ramona Mette, Kati Jegzentis, Nabavi Dg, Olaf Crome, Debra Bahr, Markus Ebke, B Platte, C Kleinen, Kai Günther, W. Heide, Oliver Pape, JR Hanssen, D Stangenberg, J. Klingelhöfer, Birgitte J. Schmidt, S. Schwarz, Julia Katharina Schwarze, L Frandlih, J Iwanow, Ingo Steinbach, Derk Krieger, G Boysen, L Leth Jeppesen, A Petersen, Heinz Reichmann, Ulrik Becker, I Dzialkowski, H. Hentschel, C Lautenschläger, H Hanso, Georg Gahn, Tjalf Ziemssen, Kirk J. Fleischer, B Sehr, W. Oliver Tobin, J. A. Kinsella, RP Murphy, Sebastian Jander, HP Hartung, M. Siebler, C Bottcher, Angelika Köhne, Jens Platzen, TC Brosig, Veit Rothhammer, C Henseler, Tobias Neumann‐Haefelin, OC Singer, Ummehan Ermis, Christoph Schuhmann, Samantha Loo, Jens Allendörfer, M Feucht S Brandtner, Keith W. Muir, Krishna Dani, Niall MacDougall, W. S. Smith, Anthony Rowe, Angela Welch, G. Schrotter, U Krenn, Susanna Horner, B Pendl, Aga Pluta-Fuerst, U. Trummer, Marios Chatzopoulos, Bettina von Sarnowski, Ulf Schminke, Thomas W. Link, Alexander V. Khaw, E Nieber, S. Zierz, Thomas Müller, Nina Wegener, K Wartenberg, Charly Gaul, Dimitrios Richter, Michael Rosenkranz, AC Krützelmann, J Hoppe, CU Choe, S Narr, TU Magnus, Götz Thomalla, Frank Leypoldt, Werner Hacke, RJ Barrows, Sami Curtze, Martti Metso, Johann Willeit, Martin Furtner, Michael Spiegel, Michael Knoflach, Barbara Prantl, OW Witte, Dirk Brämer, A Günther, Tino Prell, C Herzau, Konstanze Aurich, Günther Deuschl, Fritz Wodarg, Philip Zimmermann, Christoph Eschenfelder, Mark J. Levsen, JR Weber, SM Marecek, Dietmar Schneider, Dominik Michalski, Wolfgang Kloppig, Lea Küppers-Tiedt, M Schneider, Angela Schulz, Peter Matzen, Christopher M. Weise, Carsten Hobohm, Helen C.S. Meier, Reinhard Langos, Daniela Urban, Ilja Gerhardt, Vincent Thijs, Robin Lemmens, Evelyn Marcelis, C Hulsbosch, F. Aichner, H.‐P. Haring, E Bach, J Machado Candido, AA e Silva, Michele Ramos Lourenço, AIM de Sousa, Laurent Derex, Cho Th, Exuperio Díez‐Tejedor, Blanca Fuentes, Patricia Martínez‐Sánchez, MI Pérez-Guevara, Hajo M. Hamer, Allan K. Metz, K Hallenberger, Philippe Müller, Pierluigi Baron, Anna Bersano, Maria Paola Gattinoni, Norbert Vella, Marilyn Mallia, M. Jauß, Luise Adam, F. Heidler, C. Gube, M Kiszka, Anna Karpińska, Yvonne Mewald, Volker Straub, A Dörr, A Zollver, M. Schilling, Alex Borchert, N Preuth, Thomas Duning, Gregor Kuhlenbäumer, D Schulte, Lars Marquardt, Felix Schlachetzki, Sandra Boy, James E. Madl, GM Ertl, N.P. Fehm, Christian Stadler, R. Benecke, Aleš Dudešek, Stephan Kolbaske, G Lardurner, Christopher Sulzer, Alexander Zerbs, Stefan Lilek, AM Walleczek, D Sinadinowska, Marina Janelidze, Maya Beridze, N. Lobjanidze, Anna Dzagnidze, Arthur Melms, Karl Horber, I Fink, Benjamin Liske, AC Ludolph, K. Knauer, Corinna Hendrich, S. Raubold, Anna Członkowska, Anna Baranowska, Wilfried Lang, Wolfgang Kristoferitsch, Julia Ferrari, Elizabeth Ulrich, Agathe Flamm-Horak, Agnes Lischka-Lindner, Wolfgang Schreiber, Vida Demarin, Z Tranjec, M Bosner-Puretic, MJ Jurašić, Vanja Bašić Kes, Mislav Budišić, Lenka Kopačević
214Citations signalées, ce qui n’est pas une note de qualité
59Institutions déclarées
13Pays d’affiliation déclarés
Rattachement africain : de, at, fi, ru, gb, be, cn, pt, fr, it, mt, pl, hr.
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Le résumé fourni par la source
BACKGROUND AND PURPOSE: Strokes have especially devastating implications if they occur early in life; however, only limited information exists on the characteristics of acute cerebrovascular disease in young adults. Although risk factors and manifestation of atherosclerosis are commonly associated with stroke in the elderly, recent data suggests different causes for stroke in the young. We initiated the prospective, multinational European study Stroke in Young Fabry Patients (sifap) to characterize a cohort of young stroke patients. METHODS: Overall, 5023 patients aged 18 to 55 years with the diagnosis of ischemic stroke (3396), hemorrhagic stroke (271), transient ischemic attack (1071) were enrolled in 15 European countries and 47 centers between April 2007 and January 2010 undergoing a detailed, standardized, clinical, laboratory, and radiological protocol. RESULTS: Median age in the overall cohort was 46 years. Definite Fabry disease was diagnosed in 0.5% (95% confidence interval, 0.4%-0.8%; n=27) of all patients; and probable Fabry disease in additional 18 patients. Males dominated the study population (2962/59%) whereas females outnumbered men (65.3%) among the youngest patients (18-24 years). About 80.5% of the patients had a first stroke. Silent infarcts on magnetic resonance imaging were seen in 20% of patients with a first-ever stroke, and in 11.4% of patients with transient ischemic attack and no history of a previous cerebrovascular event. The most common causes of ischemic stroke were large artery atherosclerosis (18.6%) and dissection (9.9%). CONCLUSIONS: Definite Fabry disease occurs in 0.5% and probable Fabry disease in further 0.4% of young stroke patients. Silent infarcts, white matter intensities, and classical risk factors were highly prevalent, emphasizing the need for new early preventive strategies. Clinical Trial Registration Information- URL: http://www.clinicaltrials.gov.Unique identifier: NCT00414583.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Acute Cerebrovascular Disease in the Young
- Date Crossref
- 01/02/2013
- Éditeur
- Ovid Technologies (Wolters Kluwer Health)
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Acute Ischemic Stroke ManagementLysosomal Storage Disorders ResearchBlood Coagulation and Thrombosis Mechanisms