Derk Wolfgang Krieger

Biomarkers of atrial remodelling and risk of cardiovascular death in patients with hypertension: the LOOP study

Adam Cadovius Femerling Langhoff, Flemming Javier Olsen, Alia Saed Alhakak, Axel Brandes et autres

Abstract Background Hypertension is associated with changes in biomarkers of atrial remodelling like left atrial (LA) strain, pro-brain natriuretic peptide (pro-BNP), and high-sensitivity C-reactive protein (hsCRP). All of these biomarkers have been associated with unfavorable outcomes such as cardiovascular (CV) death, but …

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Atrial Fibrillation Screening According to Genetic Risk

Oliver Bundgaard Vad, Søren Zöga Diederichsen, Christian Paludan‐Müller, Laia Meseguer Monfort et autres

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Expert Guidance on Cognitive Impairment in Alzheimer's Disease: A Practical Seven-Step Approach from the United Arab Emirates

Taoufik M. Alsaadi, Abubaker Almadani, Suhail Alrukn, Ali Hassan et autres

INTRODUCTION: Cognitive impairment (CI) spans a spectrum from mild CI to severe dementia, with Alzheimer's disease (AD) the most prevalent cause of CI and dementia. Although dementia burden and prevalence in Arab countries reflect general global trends, the United Arab Emirates (UAE) …

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Hypokalaemia and atrial fibrillation detected by implanted loop recorders

Emilie Katrine Kongebro, Ketil Haugan, Claus Graff, Daniel Camillo Spona et autres

BACKGROUND AND AIMS: Potassium levels influence cardiac electrophysiology, yet their day-to-day association with atrial fibrillation (AF) remains unclear. This study investigated the association between plasma potassium (p-potassium) and daily AF in at-risk individuals undergoing continuous electrocardiographic monitoring. METHODS: This is a post …

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Circadian patterns of atrial fibrillation and disease progression assessed by implanted loop recorders

Daniel Camillo Spona, Ketil Haugan, Claus Graff, Søren Højberg et autres

BACKGROUND AND AIMS: The heterogeneity of atrial fibrillation (AF) necessitates better phenotyping. This study aimed to explore circadian patterns of AF and their impact on AF characteristics and progression. METHODS: Post hoc analysis of the LOOP study randomizing 6004 older, AF-naïve persons …

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Atrial fibrillation screening to prevent stroke in persons with low-normal thyrotropin

Søren Zöga Diederichsen, Daniel Camillo Spona, Diana My Frodi, Lucas Yixi Xing et autres

Abstract Background Screening for atrial fibrillation (AF) has been proposed as a method to prevent strokes in high-risk individuals. Recent trials were unable to prove efficacy for stroke prevention but suggested that a more refined approach may be beneficial. Low-normal thyroid-stimulating hormone …

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Circadian rhythm in atrial fibrillation detected by implantable loop recorder: a post-hoc analysis of a randomized clinical trial

Daniel Camillo Spona, Ketil Haugan, Claus Graff, S Hoejberg et autres

Abstract Introduction Previous studies suggest the existence of circadian, weekly, and seasonal rhythms in the occurrence of atrial fibrillation (AF), which may be utilized to improve the yield of screening. The heterogeneity of AF natural history also necessitates better phenotyping to overcome …

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Quality of life after screening for atrial fibrillation: a substudy from a randomised screening trial

Emilie Katrine Kongebro, Christian Kronborg, Ketil Haugan, Claus Graff et autres

Abstract Background Screening for atrial fibrillation (AF) is rising, yet trials have failed to show efficacy for stroke prevention from screening and subsequent anticoagulation. Quality of life is an important outcome for patients and physicians, however, it is largely unknown how this …

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Effects of Atrial Fibrillation Screening According to Thyroid Function: Post Hoc Analysis of the Randomized LOOP Study

Daniel Camillo Spona, Diana My Frodi, Lucas Yixi Xing, Emilie Katrine Kongebro et autres

CONTEXT: Subclinical thyroid dysfunction is a marker for atrial fibrillation (AF) and stroke risk. OBJECTIVE: This study explored the effects of AF screening according to thyroid-stimulating hormone (TSH) levels. METHODS: An AF screening trial (the LOOP study) was analyzed post hoc according …

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Left Atrial Strain Predicts Subclinical Atrial Fibrillation Detected by Long-term Continuous Monitoring in Elderly High-Risk Individuals

Flemming Javier Olsen, Søren Zöga Diederichsen, Peter Godsk Jørgensen, Magnus Thorsten Jensen et autres

BACKGROUND: Left atrial (LA) speckle tracking provides detailed information on atrial function. Its utility for predicting subclinical atrial fibrillation (SCAF) is unclear. Therefore, we sought to investigate whether LA strain measures could predict SCAF detected by long-term continuous rhythm monitoring. METHODS: This …

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The ABC‐Stroke Risk Score and Effects of Atrial Fibrillation Screening on Stroke Prevention: Results From the Randomized LOOP Study

Lucas Yixi Xing, Søren Zöga Diederichsen, Søren Højberg, Derk Wolfgang Krieger et autres

Background The ABC‐stroke score is a risk scheme for prediction of stroke or systemic embolism (SE) in atrial fibrillation (AF). This study sought to examine whether the score could be useful in predicting stroke in AF‐naïve individuals and risk stratifying for AF …

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Epicardial adipose tissue and subclinical incident atrial fibrillation as detected by continuous monitoring: a cardiac magnetic resonance imaging study

Eva Guldberg, Søren Zöga Diederichsen, Ketil Haugan, Axel Brandes et autres

Epicardial adipose tissue (EAT) has endocrine and paracrine functions and has been associated with metabolic and cardiovascular disease. This study aimed to investigate the association between EAT, determined by cardiac magnetic resonance imaging (CMR), and incident atrial fibrillation (AF) following long-term continuous …

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