Alexander V. Khaw

Brain-derived tau for monitoring brain injury in acute ischemic stroke

Naomi Vlegels, Nicoló Luca Knuth, Konstantin A. Steiner, Linjie Zhang et autres

A specific and accurate blood test for acute brain injury could help monitor infarct growth in ischemic stroke and serve as a surrogate end point in clinical trials. Using a single-molecule detection assay, we assessed plasma brain-derived tau (BD-tau), a marker selectively …

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Thrombolysis With Tenecteplase for Minor Disabling Stroke

Yiran Zhang, Brian H Buck, Philip A. Barber, Kausik Chatterjee et autres

Importance: Outcomes following intravenous thrombolysis for minor ischemic stroke may vary based on the presence of disabling deficits. Objective: To determine whether intravenous tenecteplase improves outcomes according to US National Institutes of Health Stroke Scale (NIHSS) score-based definitions of pretreatment disabling deficits. …

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Association of white matter injury and neuroinflammation in the post-acute phase after ischemic stroke using [18F]FEPPA-PET/MRI

Stefan E. Poirier, Rachel Wagner, Linshan Liu, Pavlo Ohorodnyk et autres

Cerebral white matter (WM) injury after ischemic stroke is associated with post-stroke cognitive impairment (PSCI), however, the interaction between sustained neuroinflammation and post-stroke WM injury is not well understood. Hybrid PET/MRI can provide insight into pathophysiological mechanisms linking chronic neuroinflammation, ischemic WM …

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Local anesthesia is associated with better functional outcomes than conscious sedation in endovascular thrombectomy for acute ischemic stroke: A retrospective analysis of the OPTIMISE registry

George Nilton Nunes Mendes, Alexandre Y Poppe, Steve Verreault, Alexander V. Khaw et autres

IntroductionThere are several possible anesthetic strategies during endovascular therapy (EVT) for acute ischemic stroke (AIS), including general anesthesia (GA), conscious sedation (CS), and local anesthesia (LA). While randomized trials have not shown a clear advantage of GA or CS, LA remains understudied. …

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Extended CT angiography versus standard CT angiography for the detection of cardioaortic thrombus in patients with ischaemic stroke and transient ischaemic attack (DAYLIGHT): a prospective, randomised, open-label, blinded end-point trial

Luciano Alberto Sposato, Diana Paula Ayan, Mobeen Ahmed, Sebastián Fridman et autres

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Impact of Brain Frailty on Clinical Presentation and Neurologic Recovery in Acute Ischemic Stroke Patients Undergoing Thrombectomy

Joachim Fladt, Faysal Benali, Tanaporn Jaroenngarmsamer, Fouzi Bala et autres

Background and ObjectivesBrain frailty impairs the ability to compensate for brain dysfunction and is linked to worse outcomes after stroke. Stroke severity at presentation is a key determinant of outcomes in acute ischemic stroke. This study aimed to examine the impact of …

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Sex Differences in Outcomes After Tenecteplase for Minor Stroke: A Subanalysis of the TEMPO‐2 Trial

Amy Yu, Shabnam Vatanpour, Aravind Ganesh, Thalia Shoshana Field et autres

BACKGROUND: In this subanalysis of the TEMPO-2 (Tenecteplase Versus Standard of Care for Minor Ischaemic Stroke With Proven Occlusion) trial, a randomized clinical trial comparing tenecteplase and nonthrombolytic control in patients with minor stroke and symptomatic intracranial occlusion, we investigated sex differences …

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Time-varying differences in stroke recurrence risk between types of atrial fibrillation based on screening methods and timing of detection

Alonso Alvarado‐Bolaños, Diana Paula Ayan, Facundo Lodol, Alexander V. Khaw et autres

INTRODUCTION: Atrial fibrillation (AF) burden progresses with time. Among ischemic stroke (IS) patients, AF can be detected at different burden progression stages based on the timing and screening method. We hypothesized that AF detected after IS on 12-lead ECGs (ECG-AF) and via …

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Evidence of diffusion tensor imaging measures of white matter microstructure changes within six months after stroke

Stefan E. Poirier, Jonathan Dale Thiessen, Alexander V. Khaw, Udunna Anazodo

White matter (WM) damage is associated with post-stroke cognitive impairment. In this study, we used diffusion tensor imaging (DTI) to investigate changes in WM microstructure in patients within 6-months following stroke. Quantitative DTI measurements were compared in patients at 6-months relative to …

Improving Low Resolution MRI Contrast for Brain-Environment Neuroepidemiology

Jasmine D. Cakmak, Reza Azarpazhooh, Alexander V. Khaw, Udunna Anazodo

Recycling large-scale clinical data to retrospectively study associations of brain imaging variables with emerging environmental risk factors is a sustainable approach in the growing field of neuroepidemiology. Here, we evaluated the utility of a deep learning tool to increase the resolution of …

The treatment effect across ASPECTS in acute ischemic stroke: Analysis from the AcT trial

Chitapa Kaveeta, Ibrahim Alhabli, Fouzi Bala, MacKenzie Horn et autres

BACKGROUND: Early ischemic changes on baseline imaging are commonly evaluated for acute stroke decision-making and prognostication. AIMS: We assess the association of early ischemic changes on clinical outcomes and whether it differs between intravenous tenecteplase and Alteplase. METHODS: Data are from the …

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Enhancement of low-resolution MRI contrast using super resolution for environmental neuroepidemiology

Jasmine D. Cakmak, Alexander V. Khaw, Reza Azarpazhooh, Michael Todd Jurkiewicz et autres

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