PA200 modulates immunoproteasome structure and activity
Dušan Živković, Amélie Bosc-Rosati, Angélique Sanchez Dafun, Fatme Mourtada et autres
The proteasome activator PA200 binds to the catalytic core of both standard proteasome (s20S) and the immunoproteasome (i20S); however, whether PA200 uses the same mechanisms to activate i20S remains unknown. In this work, the cryo-EM structures of singly- and doubly-capped i20S-PA200 complexes, …
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Nature Communications