Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation
Qianru Mu, Ryo� Saito, Franceska Ozola, Dawid Jaślan et autres
Abstract Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is …
gb, jp, de, us (code pays fourni par la source)
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