Qianru Mu

Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation

Qianru Mu, Ryo� Saito, Franceska Ozola, Dawid Jaślan et autres

Abstract Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is …

gb, jp, de, us (code pays fourni par la source)

Liquid liquid phase separation of the intrinsically disordered protein JPT2 compartmentalizes components of NAADP-evoked Ca 2+ signaling

Sushil Kumar, Gihan S. Gunaratne, Jasmine Cornish, Kirsten M Silvey et autres

ABSTRACT Nicotinic acid adenine dinucleotide phosphate (NAADP) is a Ca 2+ -releasing second messenger that activates two-pore channels (TPCs) on endosomes and lysosomes. Rather than binding TPCs directly, NAADP acts through cytoplasmic NAADP-binding proteins (NAADP-BPs) which are essential for endolysosomal Ca 2+ …

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Allosteric switching of Ca2+ permeability in the lysosomal ion channel TPC2 underpins biased agonist activation

Qianru Mu, Ryo� Saito, Franceska Ozola, Dawid Jaślan et autres

Ion channels possess selectivity filters that are hardwired to ensure the selective passage of ions. Lysosomal two-pore channels are unusual as they are able to switch their cation selectivity in an agonist-specific manner, allowing differential control of organellar activity. TPC2 is permeable …

In-vehicle device data tampering detection: Accurate identification based on correlation calculation and data relationship

Zigang Chen, Hongwei Zhang, Qianru Mu, Danlong Li et autres

cn (code pays fourni par la source)

NAADP signaling: Master manipulation

Qianru Mu, Jade L. Harris, David I. Yule, James T. Slama et autres

gb, us (code pays fourni par la source)

Two-pore channel-2 and inositol trisphosphate receptors coordinate Ca2+ signals between lysosomes and the endoplasmic reticulum

Yu Yuan, Vikas Arige, Ryo� Saito, Qianru Mu et autres

Lysosomes and the endoplasmic reticulum (ER) are Ca 2+ stores mobilized by the second messengers NAADP and IP 3 , respectively. Here, we establish Ca 2+ signals between the two sources as fundamental building blocks that couple local release to global changes …

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Convergent activation of Ca 2+ permeability in two-pore channel 2 through distinct molecular routes

Ryo� Saito, Qianru Mu, Yu Yuan, Marcos Rubio‐Alarcón et autres

TPC2 is a pathophysiologically relevant lysosomal ion channel that is activated directly by the phosphoinositide PI(3,5)P 2 and indirectly by the calcium ion (Ca 2+ )–mobilizing molecule NAADP through accessory proteins that associate with the channel. TPC2 toggles between PI(3,5)P 2 -induced, …

jp, gb, us, de (code pays fourni par la source)

A styrylpyrone dimer from the bark of Goniothalamus leiocarpus

Qianru Mu, Yn He, WD Tang, CM Li et autres

A dimer of styrylpyrone derivative, leiocarpin E. (1), was isolated from the bark of Goniothalamus leiocarpus. its structures was elucidated by means of spectral and chemical methods. The cytotoxicity of leiocarpin E against HL-60 cells was tested.

Three new styrylpyrones from Goniothalamus leiocarpus

Qianru Mu, CM Li, Yn He, HD Sun et autres

Three new styrylpyrones. named 7-epi-goniodiol 1. leiocarpin B 2 and leiocarpin C 3. were isolated from the stem barks of Goniothalamus leiocarpus. Their structures were elucidated by means of spectral and chemical methods. The relative configuration of 1 and 2 were determined …

A new styryl-lactone compound from Goniothalamus leiocarpus

Qianru Mu, CM Li, Hongjie Zhang, Yangjie Wu et autres

A new styryl-lactone compound, named as leiocarpin A (1), was isolated from Goniothalamus leiocarpus. Its structure and relative configuration were determined by means of spectrum particularly 2D NMR including H-1-H-1 COSY, H-1-C-13 HETCOR, COLOC and NOESY techniques.