Accès ouvert
2026
article
OpenAlex
Qian Zhang, Eathar Shakweh, Mohmmed Tauseef Sharip, Benjamin Zaré et autres
BACKGROUND: The association between HLA-DRB1*01:03 and severe ulcerative colitis has long been recognised. However, the recent discovery of an association with neutralising auto-antibodies against IL-10 raises new questions about whether this haplotype contributes to other subphenotypes of inflammatory bowel disease (IBD). We …
gb
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
James Hassall, Thean Chew, MF Hale, Anupam Rej et autres
Introduction Infliximab (IFX) improves outcomes in Inflammatory Bowel Disease; however secondary loss of response (LOR) occurs in up to 60% of patients at 3 years. Data on long–term outcomes following proactive therapeutic drug monitoring (TDM) combined with IFX dose escalation (DE) is …
gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Keith Bodger, C Booker, Frederick Taylor, Tariq Ahmad et autres
Background: VEST was a multi-centre study of real-world use of vedolizumab in inflammatory bowel disease (IBD) in routine practice in the United Kingdom. Objectives: To describe real-world indications, effectiveness, patient-reported outcomes and safety. Design: Prospective observational cohort study at 22 centres. Methods: …
gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Nilofer Husnoo, Alexandra Whitman, Jenna Morgan, Lynda Wyld et autres
Objective Growing evidence supports earlier surgery for isolated terminal ileal Crohn’s disease, yet clinicians perceive patient reluctance as a barrier to surgery. This study explored patients’ perspectives on surgery in this context to understand factors shaping treatment preferences and decision-making. Method Semistructured …
gb
(code pays fourni par la source)
2026
conference-abstract
OpenAlex
Nilofer Husnoo, Lucy Wyld, Jennifer Morgan, A Lobo et autres
Abstract Background Growing evidence supports earlier surgery for isolated terminal ileal (TI) Crohn’s disease (CD), yet clinical practice remains variable, with surgery often reserved for medical treatment failure. Through this multicentre mixed-methods study, we aimed to understand the evidence-practice gap by exploring …
gb
(code pays fourni par la source)