Accès ouvert
2026
article
OpenAlex
Nilofer Husnoo, Alexandra Whitman, Jenna Morgan, Lynda Wyld et autres
Objective Growing evidence supports earlier surgery for isolated terminal ileal Crohn’s disease, yet clinicians perceive patient reluctance as a barrier to surgery. This study explored patients’ perspectives on surgery in this context to understand factors shaping treatment preferences and decision-making. Method Semistructured …
gb
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Nilofer Husnoo, Ruchika Yadav Nongrum, Thomas Hall, Alexandra Whitman et autres
BACKGROUND: Medical therapy is often favoured in the treatment of ileocaecal Crohn's disease (CD), with surgery often reserved for treatment failure. Data from the 'pre-biological' era suggest that most patients who had an ileocolic resection for CD would have preferred to have …
gb, br
(code pays fourni par la source)
2025
article
OpenAlex
Nilofer Husnoo, Alexandra Whitman, Alan Lobo, Jenna Morgan et autres
Abstract Aims Surgery for Crohn’s disease (CD) is considered when medical therapy is unsuccessful. Evidence shows that earlier bowel resection offers more stable remission for localised luminal ileocaecal disease. The adoption of earlier surgery into practice is challenging. We aimed to establish …
gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Nilofer Husnoo, Alexandra Whitman, Jenna Morgan, Lynda Wyld et autres
Abstract Background Surgery for Crohn’s disease (CD) is considered when medical therapy is unsuccessful. Evidence shows that earlier bowel resection offers more stable remission for localised luminal ileocaecal disease. The adoption of earlier surgery into practice is challenging. We aimed to establish …
gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Alexandra Whitman, Judith Johnston, Nilofer Husnoo
Abstract Aim Most patients with Crohn’s disease (CD) have at least one bowel resection during their lifetime. 80% of patients with terminal ileal CD (the most common phenotype) will require a bowel resection at some point. Patients considering a bowel resection for …
gb, Zambie
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Claire J. Ciampa, Jourdan H. Parent, Molly R. LaPoint, Kaitlin N. Swinnerton et autres
Aging is associated with declines in multiple components of the dopamine system including loss of dopamine-producing neurons, atrophy of the dopamine system's cortical targets, and reductions in the density of dopamine receptors. Countering these patterns, dopamine synthesis appears to be stable or …
us
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Suzanne L. Baker, Karine Provost, Wesley P. Thomas, Alexandra Whitman et autres
Abstract Background Current tau PET tracers have obvious shortcomings. 18F‐JNJ‐64326067 (18F‐JNJ‐067) is a new tau tracer that binds to aggregated tau in Alzheimer’s Disease (AD) brain tissue with Ki=2.4nM. Our objective was to evaluate 18F‐JNJ‐067 in individuals with AD (N=3), Mild Cognitive …
us, be
(code pays fourni par la source)
Accès ouvert
2020
article
OpenAlex
Alexis Moscoso, Alexandra Whitman, Suzanne L. Baker, Renaud La Joie et autres
Abstract Background Recent research has suggested that the use of white matter (WM) reference regions for longitudinal tau PET imaging might result in more stable estimates of tau accumulation. However, tau tracers display affinity for the β‐sheet structure formed by proteins such …
se, us, de
(code pays fourni par la source)