Anupam Rej

P382 GI manifestations of hypogammaglobulinaemia: a retrospective study

Kimberley Butler, Sarah Denness, Anupam Rej, Foong Way David Tai et autres

Introduction Hypogammaglobulinemia represents a heterogeneous group of immunodeficiency disorders caused by low serum antibodies, resulting in recurrent infections and increased susceptibility to autoimmune and inflammatory complications. Patients with significant infectious complications are treated with immunoglobulin infusions. Many patients with immunodeficiency have concurrent …

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P255 Proactive therapeutic drug monitoring and dose escalation are associated with sustained intravenous infliximab persistence beyond five years

James Hassall, Thean Chew, MF Hale, Anupam Rej et autres

Introduction Infliximab (IFX) improves outcomes in Inflammatory Bowel Disease; however secondary loss of response (LOR) occurs in up to 60% of patients at 3 years. Data on long–term outcomes following proactive therapeutic drug monitoring (TDM) combined with IFX dose escalation (DE) is …

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Prevalence of eating disorder risk in irritable bowel syndrome, coeliac and inflammatory bowel diseases using SCOFF

W. J. Holland, Suneil A Raju, Millie Newton, Anupam Rej et autres

Introduction Eating disorders (EDs) and disordered eating behaviours are common in the general population. Those with gastrointestinal (GI) disorders may be particularly at risk, as they may need dietary therapies. There are no direct comparisons of the risk of EDs in patients …

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Does a Gluten-Free Diet Improve Quality of Life and Sleep in Patients with Non-Coeliac Gluten/Wheat Sensitivity?

Connor Cotton, Suneil A Raju, Hamza Ahmed, Grace Webster et autres

Introduction: The role of a gluten-free diet (GFD) in Non-Coeliac Gluten/Wheat Sensitivity (NCGWS) is unclear. We present the largest study comparing adherence to a GFD in patients with Coeliac Disease (CD) and NCGWS and assess its impact on quality of life (QoL) …

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P166 Does adherence to a gluten-free diet affect quality of life and sleep in patients with Non-Coeliac Gluten/Wheat Sensitivity?

Connor Cotton, Suneil A Raju, Hamza Ahmed, Grace Webster et autres

Introduction A gluten-free diet is the treatment for patients with coeliac disease, but the evidence for its use in Non-Coeliac Gluten/Wheat Sensitivity (NCGWS) is limited. We present the largest study assessing to what extent adherence to a gluten free diet in NCGWS …

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P103 Long term treatment with tofacitinib for ulcerative colitis refractory to anti-tumour necrosis factor agents: real-world experience from a single centre

Malik Satea El Atrash, Omar T. Ahmed, Mohamed Yehia Hamdy, Alenka J Brooks et autres

Introduction Tofacitinib is a pan-Janus Kinase inhibitor which is effective for induction and maintenance of remission in moderate to severely active ulcerative colitis (UC). The safety and efficacy of tofacitinib in UC patients has been demonstrated in trials. Long term experience is …

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Current evidence for dietary therapies in irritable bowel syndrome

Anupam Rej, Hugo A. Penny

PURPOSE OF REVIEW: Diet appears to trigger symptoms in the majority of individuals with irritable bowel syndrome (IBS) and is associated with a reduced quality of life. There has been a recent focus on the role of dietary therapies to manage individuals …

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The truth about gluten!

Suneil A Raju, Anupam Rej, David S. Sanders

Wheat was first cultivated in the Fertile Crescent (South Western Asia) with a farming expansion that lasted from around 9000 BC to 4000 BC. Whilst humans have been exposed to wheat for around the last 10 000 years, humans have existed for …

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Long-term follow-up in patients with coeliac disease in the pandemic-era: a view from Sheffield the NHS England national centre for adult coeliac disease.

Nick Trott, Suneil A Raju, Anupam Rej, Olivia Hoffman et autres

Aim: To explore patients' follow-up preferences. Background: Optimal follow-up strategies for patients with coeliac disease remain a subject of debate. Research suggests patients' prefer review by dietitians with a doctor available as required. Methods: Patients with coeliac disease under review at our …

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What are the clinical consequences of ‘potential’ coeliac disease?

Millie Newton, Emily A Greenaway, W. J. Holland, Suneil A Raju et autres

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DQA1*0102 DQB1*0602 haplotype distinguishes coeliac disease and its complications from gluten unrelated enteropathies

Annalisa De Silvestri, Annalisa Schiepatti, Bryce D Fowler, Carla Badulli et autres

BACKGROUND: Duodenal villous atrophy is due not only to coeliac disease and its complications but also to other rare enteropathies unrelated to gluten consumption, defined as noncoeliac enteropathies. The diagnosis of noncoeliac enteropathies remains challenging, and HLA typing has been widely used …

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Does reverse mentoring work in the NHS: a feasibility study of clinicians in practice

Suneil A Raju, Hey‐Long Ching, Mustafa Jalal, Michelle Lau et autres

OBJECTIVE: To assess the risks and benefits of reverse mentoring of consultants by junior doctors. DESIGN: A feasibility study divided into two phases: first a semistructured interview where performance of participating consultants was assessed by junior doctors and then a second phase …

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