Liping Chen

Synthesis of isoquinoline N-oxides via direct annulation with cyclic dicarbonyls

Xin Chen, XinYing Li, Xin Huang, Yuehong Zou et autres

An efficient Rh(III)-catalyzed, regioselective oxidative annulation of substituted aryl ketoximes with cyclic 1,3-dicarbonyl compounds for the divergent synthesis of polysubstituted isoquinoline N -oxides is described. This protocol utilizes PhI(OAc)₂ as a terminal oxidant to generate a highly reactive iodonium ylide intermediate in …

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Liposome-mediated simvastatin in vaccine adjuvants: Its application and mechanism

Zhijie Chen, Zhiwu Xia, Liping Chen, Qingqing Nie et autres

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Computational Insights into Divergent Pd-Catalyzed Oxidations with Oxone: Unveiling Dual Wacker and Oxo-Hydroxylation Pathways

Zhuanzhuan Su, Liping Chen, Shuaizhong Zhang, Xianwen Zeng et autres

High Resolution Image Download MS PowerPoint Slide Pd(II)-catalyzed Wacker oxidation represents a robust and attractive route to methyl ketones from terminal alkenes in modern organic synthesis. In this work, we report a tunable oxidation system that employs oxone (potassium peroxymonosulfate) as a …

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Rhodium-Catalyzed Oxidative Pyrrole Cyclization of Acetophenone with Alkynyl derivatives via Transient-Directing-Group

Liping Chen, Xianwen Zeng, Xue Wang, Wenjie Lan et autres