Xin Huang

Synthesis of isoquinoline N-oxides via direct annulation with cyclic dicarbonyls

Xin Chen, XinYing Li, Xin Huang, Yuehong Zou et autres

An efficient Rh(III)-catalyzed, regioselective oxidative annulation of substituted aryl ketoximes with cyclic 1,3-dicarbonyl compounds for the divergent synthesis of polysubstituted isoquinoline N -oxides is described. This protocol utilizes PhI(OAc)₂ as a terminal oxidant to generate a highly reactive iodonium ylide intermediate in …

cn (code pays fourni par la source)

Score-Based Matching with Target Guidance for Cryo-EM Denoising

Xiaoqi Wu, Xueying Zhan, Wen Li, Junhao Wu et autres

Cryo-electron microscopy (cryo-EM) enables single-particle analysis of biological macromolecules under strict low-dose imaging conditions, but the resulting micrographs often exhibit extremely low signal-to-noise ratios and weak particle visibility. Image denoising is therefore an important preprocessing step for downstream cryo-EM analysis, including particle …